{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:54:01Z","timestamp":1787727241585,"version":"build-2784847793"},"reference-count":32,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007469","name":"Alfred Benzon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Acromegaly is an insidious disease associated with severe somatic morbidity but data on socioeconomic status are scarce.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To study the socioeconomic status in acromegaly in a population-based follow-up study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All incident cases of acromegaly (n = 576) during the period 1977-2010 were included. For every patient, 100 persons were sampled from the general population matched for date of birth and gender (comparison cohort). Cox regression and hazard ratios (HR), conditional logistic regression and linear regression with 95% confidence intervals (CI) were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome Measures<\/jats:title>\n                  <jats:p>Retirement, social security benefit, annual income, cohabitation, separation, parenthood and educational level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The proportion of retired individuals was significantly higher in patients with acromegaly after the time of diagnosis (HR, 1.43; 95% CI, 1.26-1.62) and also during the 5-year pre-diagnostic period (HR, 1.15; 95% CI, 1.03-1.28). More individuals with acromegaly received social security benefit compared with the comparison cohort during the initial period after the time of diagnosis. Among patients who maintained a job, the annual income was similar to the comparison cohort. Compared with the background population, cohabitation was lower (HR, 0.69; 95% CI, 0.50-0.95) as was parenthood (HR, 0.56; 95% CI, 0.39-0.80), whereas neither educational level (HR, 0.61; 95% CI, 0.35-1.06) nor separation (HR, 1.13; 95% CI, 0.86-1.47) were different. Female gender and insufficient disease control were associated with a significantly worse socioeconomic status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>1) Socioeconomic status is impaired in patients with acromegaly even before a diagnosis of acromegaly. 2) Females and patients without disease remission have worse outcomes. 3) Early diagnosis and effective treatment of acromegaly could be important factors in mitigating the negative impact on socioeconomic factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa405","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T23:23:54Z","timestamp":1593300234000},"page":"2975-2982","source":"Crossref","is-referenced-by-count":20,"title":["Disease Control and Gender Predict the Socioeconomic Effects of Acromegaly: A Nationwide Cohort Study"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0610-7867","authenticated-orcid":false,"given":"Jakob","family":"Dal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Steno Diabetic Center North Jutland, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eigil H","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla-Feldt","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, National University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus L","family":"Feltoft","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Herlev University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Steno Diabetic Center North Jutland, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine","family":"Stochholm","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Herlev University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Otto L","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aarhus University Hospital, Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"issue":"3","key":"2021122203020247800_CIT0001","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/EJE-16-0117","article-title":"Acromegaly incidence, prevalence, complications and long-term prognosis: a nationwide cohort study","volume":"175","author":"Dal","year":"2016","journal-title":"Eur J Endocrinol."},{"key":"2021122203020247800_CIT0002","first-page":"691","article-title":"Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients","author":"Sievers","year":"2009"},{"issue":"3","key":"2021122203020247800_CIT0003","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s12020-014-0521-6","article-title":"Disease control and treatment modalities have impact on quality of life in acromegaly evaluated by Acromegaly Quality of Life (AcroQoL) Questionnaire","volume":"49","author":"Vandeva","year":"2015","journal-title":"Endocrine."},{"key":"2021122203020247800_CIT0004","first-page":"997","article-title":"Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006; 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