{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:33:34Z","timestamp":1790969614581,"version":"4.1.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing\u2019s disease (CD) when dexamethasone-suppression and CRH tests, and pituitary magnetic resonance imaging (MRI), are negative or give discordant results. However, IPSS is an invasive procedure and its availability is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To test a noninvasive diagnostic strategy associated with 100% positive predictive value (PPV) for CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two university hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>A total of 167 patients with CD and 27 patients with ectopic ACTH-syndrome investigated between 2001 and 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>Performance of a strategy involving the CRH and desmopressin tests with pituitary MRI followed by thin-slice whole-body computed tomography (CT) scan in patients with inconclusive results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using thresholds of a cortisol increase &amp;gt; 17% with an ACTH increase &amp;gt; 37% during the CRH test and a cortisol increase &amp;gt; 18% with an ACTH increase &amp;gt; 33% during the desmopressin test, the combination of both tests gave 73% sensitivity and 98% PPV of CD. The sensitivity and PPV for pituitary MRI were 71% and 99%, respectively. CT scan identified 67% EAS at presentation with no false-positives. The PPV for CD was 100% in patients with positive responses to both tests, with negative pituitary MRI and CT scan. The Negative Predictive Value was 100% in patients with negative responses to both tests, with negative pituitary MRI and positive CT scan. Using this strategy, IPPS could have been avoided in 47% of patients in whom it is currently recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conjunction with expert radiologic interpretation, the non-invasive algorithm studied significantly reduces the need for IPSS in the investigation of ACTH-dependent Cushing\u2019s syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa409","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T20:04:29Z","timestamp":1593288269000},"page":"3273-3284","source":"Crossref","is-referenced-by-count":99,"title":["Non-invasive Diagnostic Strategy in ACTH-dependent Cushing\u2019s Syndrome"],"prefix":"10.1210","volume":"105","author":[{"given":"Caroline","family":"Frete","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Beno\u00eet","family":"Corcuff","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Bordeaux, Pessac, France"},{"name":"Nutrition et Neurobiologie Int\u00e9gr\u00e9e, UMR 1286, University of Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gaye","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital of Bordeaux, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Le Kremlin-Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et M\u00e9tabolique, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Le Kremlin-Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et M\u00e9tabolique, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-3306","authenticated-orcid":false,"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, Pessac, France"},{"name":"Physiopathologie de la Plasticit\u00e9 Neuronale, INSERM U1215, Neurocentre Magendie, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"issue":"8","key":"2021122105523911600_CIT0001","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1210\/jc.2015-1818","article-title":"Treatment of Cushing\u2019s syndrome: an endocrine society clinical practice guideline","volume":"100","author":"Nieman","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122105523911600_CIT0002","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ecl.2018.01.005","article-title":"The ectopic adrenocorticotropic hormone syndrome: rarely easy, always challenging","volume":"47","author":"Hayes","year":"2018","journal-title":"Endocrinol Metab Clin North Am."},{"issue":"9996","key":"2021122105523911600_CIT0003","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing\u2019s syndrome","volume":"386","author":"Lacroix","year":"2015","journal-title":"Lancet."},{"issue":"2","key":"2021122105523911600_CIT0004","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3171\/2016.1.JNS152119","article-title":"Cushing\u2019s disease: pathobiology, diagnosis, and management","volume":"126","author":"Lonser","year":"2017","journal-title":"J Neurosurg."},{"issue":"10","key":"2021122105523911600_CIT0005","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2006-0997","article-title":"Cushing\u2019s syndrome: important issues in diagnosis and management","volume":"91","author":"Findling","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122105523911600_CIT0006","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ecl.2005.01.009","article-title":"Differential diagnosis and imaging in Cushing\u2019s syndrome","volume":"34","author":"Lindsay","year":"2005","journal-title":"Endocrinol Metab Clin North Am."},{"issue":"9","key":"2021122105523911600_CIT0007","first-page":"3401","article-title":"One transient neurological complication (sixth nerve palsy) in 166 consecutive inferior petrosal sinus samplings for the etiological diagnosis of Cushing\u2019s syndrome","volume":"84","author":"Lefournier","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122105523911600_CIT0008","first-page":"487","article-title":"A critical analysis of the value of simultaneous inferior petrosal sinus sampling in Cushing\u2019s disease and the occult ectopic adrenocorticotropin syndrome","volume":"84","author":"Kaltsas","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122105523911600_CIT0009","first-page":"1\u20137","article-title":"The role of inferior petrosal sinus sampling in ACTH-dependent Cushing\u2019s syndrome: review and joint opinion statement by members of the Italian Society for Endocrinology, Italian Society for Neurosurgery, and Italian Society for Neuroradiology","volume":"38","author":"Pecori Giraldi","year":"2015","journal-title":"Neurosurg Focus."},{"issue":"1","key":"2021122105523911600_CIT0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7326\/0003-4819-128-1-199801010-00006","article-title":"Bilateral sampling of the internal jugular vein to distinguish between mechanisms of adrenocorticotropic hormone-dependent Cushing syndrome","volume":"128","author":"Doppman","year":"1998","journal-title":"Ann Intern Med."},{"issue":"8","key":"2021122105523911600_CIT0011","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1210\/jc.2003-032249","article-title":"Diagnostic errors after inferior petrosal sinus sampling","volume":"89","author":"Swearingen","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2021122105523911600_CIT0012","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-2265.1998.00401.x","article-title":"Overnight urinary free cortisol determination: a screening test for the diagnosis of Cushing\u2019s syndrome","volume":"48","author":"Corcuff","year":"1998","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"6","key":"2021122105523911600_CIT0013","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1210\/jc.2006-2691","article-title":"The application of the combined corticotropin-releasing hormone plus desmopressin stimulation during petrosal sinus sampling is both sensitive and specific in differentiating patients with Cushing\u2019s disease from patients with the occult ectopic adrenocorticotropin syndrome","volume":"92","author":"Tsagarakis","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021122105523911600_CIT0014","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jcem-73-1-53","article-title":"Usefulness of the corticotropin-releasing hormone test during bilateral inferior petrosal sinus sampling for the diagnosis of Cushing\u2019s disease","volume":"73","author":"Tabarin","year":"1991","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122105523911600_CIT0015","first-page":"1308","article-title":"A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing\u2019s syndrome","volume":"77","author":"Nieman","year":"1993","journal-title":"J Clin Endocrinol Metab."},{"issue":"12","key":"2021122105523911600_CIT0016","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jc.2003-030871","article-title":"Diagnosis and complications of Cushing\u2019s syndrome: a consensus statement","volume":"88","author":"Arnaldi","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122105523911600_CIT0017","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2019-00333","article-title":"Why we should still treat by neurosurgery patients with Cushing\u2019s disease and a normal or inconclusive pituitary MRI","author":"Cristante","year":"2019;104(9):4101\u20134113","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122105523911600_CIT0018","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0033-8389(03)00031-9","article-title":"Lung nodule detection and characterization with multislice CT","volume":"41","author":"Ko","year":"2003","journal-title":"Radiol Clin North Am."},{"issue":"6","key":"2021122105523911600_CIT0019","first-page":"1780","article-title":"Effectiveness versus efficacy: the limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing\u2019s syndrome","volume":"82","author":"Aron","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122105523911600_CIT0020","first-page":"440","article-title":"Diagnosis and management of Cushing\u2019s syndrome: results of an Italian multicentre study. Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis","volume":"84","author":"Invitti","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2021122105523911600_CIT0021","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1210\/jc.2003-030510","article-title":"Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing\u2019s syndrome","volume":"88","author":"Isidori","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021122105523911600_CIT0022","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.1365-2265.2003.01776.x","article-title":"The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing\u2019s syndrome","volume":"58","author":"Reimondo","year":"2003","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"5","key":"2021122105523911600_CIT0023","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1530\/EJE-18-0007","article-title":"Diagnosis of endocrine disease: the role of the desmopressin test in the diagnosis and follow-up of Cushing\u2019s syndrome","volume":"178","author":"Vassiliadi","year":"2018","journal-title":"Eur J Endocrinol."},{"issue":"4","key":"2021122105523911600_CIT0024","first-page":"1640","article-title":"Optimal response criteria for the human CRH test in the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome","volume":"87","author":"Newell-Price","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122105523911600_CIT0025","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI118547","article-title":"The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome","volume":"97","author":"de Keyzer","year":"1996","journal-title":"J Clin Invest."},{"issue":"4","key":"2021122105523911600_CIT0026","first-page":"1646","article-title":"The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion","volume":"87","author":"Tsagarakis","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122105523911600_CIT0027","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s11102-016-0729-y","article-title":"Second-line tests in the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome","volume":"19","author":"Barbot","year":"2016","journal-title":"Pituitary."},{"issue":"6","key":"2021122105523911600_CIT0028","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1365-2265.1997.1330954.x","article-title":"Effect of desmopressin on ACTH and cortisol secretion in states of ACTH excess","volume":"46","author":"Colombo","year":"1997","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"5","key":"2021122105523911600_CIT0029","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2265.1993.tb00341.x","article-title":"The desmopressin stimulation test in the differential diagnosis of Cushing\u2019s syndrome","volume":"38","author":"Malerbi","year":"1993","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"1","key":"2021122105523911600_CIT0030","first-page":"176","article-title":"A combined test using desmopressin and corticotropin-releasing hormone in the differential diagnosis of Cushing\u2019s syndrome","volume":"82","author":"Newell-Price","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122105523911600_CIT0031","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1507\/endocrj.44.687","article-title":"Desmopressin stimulation test for diagnosis of ACTH-dependent Cushing\u2019s syndrome","volume":"44","author":"Sakai","year":"1997","journal-title":"Endocr J."},{"issue":"3","key":"2021122105523911600_CIT0032","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1507\/endocrj.K08E-353","article-title":"Evaluation of diagnostic tests for ACTH-dependent Cushing\u2019s syndrome","volume":"56","author":"Suda","year":"2009","journal-title":"Endocr J."},{"issue":"5","key":"2021122105523911600_CIT0033","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1365-2265.2001.01260.x","article-title":"The limited value of the desmopressin test in the diagnostic approach to Cushing\u2019s syndrome","volume":"54","author":"Terzolo","year":"2001","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"4","key":"2021122105523911600_CIT0034","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-2265.1999.00830.x","article-title":"Assessment of cortisol and ACTH responses to the desmopressin test in patients with Cushing\u2019s syndrome and simple obesity","volume":"51","author":"Tsagarakis","year":"1999","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"10","key":"2021122105523911600_CIT0035","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-120-10-199405150-00001","article-title":"Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population","volume":"120","author":"Hall","year":"1994","journal-title":"Ann Intern Med."},{"issue":"3","key":"2021122105523911600_CIT0036","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1046\/j.1365-2265.1998.00541.x","article-title":"Comparative evaluation of conventional and dynamic magnetic resonance imaging of the pituitary gland for the diagnosis of Cushing\u2019s disease","volume":"49","author":"Tabarin","year":"1998","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"6","key":"2021122105523911600_CIT0037","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1210\/jc.2012-3943","article-title":"The lateralization accuracy of inferior petrosal sinus sampling in 501 patients with Cushing\u2019s disease","volume":"98","author":"Wind","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122105523911600_CIT0038","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1210\/jc.2009-2282","article-title":"Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin-secreting tumors","volume":"95","author":"Zemskova","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"2021122105523911600_CIT0039","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1210\/JC.2015-1589","article-title":"Conventional and nuclear medicine imaging in ectopic Cushing\u2019s syndrome: a systematic review","volume":"100","author":"Isidori","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2021122105523911600_CIT0040","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1530\/EJE-19-0877","article-title":"Management of endocrine disease: Cushing\u2019s syndrome due to ectopic ACTH secretion: an expert operational opinion","volume":"182","author":"Young","year":"2020","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2021122105523911600_CIT0041","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-019-0447-x","article-title":"End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography","volume":"25","author":"Ardila","year":"2019","journal-title":"Nat Med."},{"issue":"1","key":"2021122105523911600_CIT0042","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3171\/JNS\/2008\/108\/01\/0009","article-title":"Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35 years","volume":"108","author":"Hofmann","year":"2008","journal-title":"J Neurosurg."},{"issue":"7","key":"2021122105523911600_CIT0043","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1210\/jc.2003-031908","article-title":"Pituitary magnetic resonance imaging findings do not influence surgical outcome in adrenocorticotropin-secreting microadenomas","volume":"89","author":"Salenave","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"issue":"7","key":"2021122105523911600_CIT0044","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S2213-8587(16)30005-5","article-title":"Mortality in patients with Cushing\u2019s disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study","volume":"4","author":"Clayton","year":"2016","journal-title":"Lancet Diabetes Endocrinol."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa409\/33565298\/dgaa409.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/10\/3273\/41828128\/dgaa409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/10\/3273\/41828128\/dgaa409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:53:03Z","timestamp":1640047983000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/10\/3273\/5864157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,27]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,6,27]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa409","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,6,27]]}}}