{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:01:52Z","timestamp":1784761312333,"version":"3.55.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271-TRR\/CRC 205"],"award-info":[{"award-number":["314061271-TRR\/CRC 205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union Horizon 2020 Program","award":["633983-2"],"award-info":[{"award-number":["633983-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study addresses the hypothesis that patients with pheochromocytoma and paraganglioma (PPGL) have altered steroid production compared with patients with primary hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Multicenter cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Twelve European referral centers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Subjects included 182 patients with pheochromocytoma, 36 with paraganglioma and 270 patients with primary hypertension. Patients with primary aldosteronism (n = 461) and Cushing syndrome (n = 124) were included for additional comparisons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>In patients with PPGLs, surgical resection of tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome measures<\/jats:title>\n                  <jats:p>Differences in mass spectrometry\u2013based profiles of 15 adrenal steroids between groups and after surgical resection of PPGLs. Relationships of steroids to plasma and urinary metanephrines and urinary catecholamines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with pheochromocytoma had higher (P &amp;lt; .05) circulating concentrations of cortisol, 11-deoxycortisol, 11-deoxycorticosterone, and corticosterone than patients with primary hypertension. Concentrations of cortisol, 11-deoxycortisol, and corticosterone were also higher (P &amp;lt; .05) in patients with pheochromocytoma than with paraganglioma. These steroids correlated positively with plasma and urinary metanephrines and catecholamines in patients with pheochromocytoma, but not paraganglioma. After adrenalectomy, there were significant decreases in cortisol, 11-deoxycortisol, corticosterone, 11-deoxycorticosterone, aldosterone, and 18-oxocortisol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first large study in patients with PPGLs that supports in a clinical setting the concept of adrenal cortical\u2013medullary interactions involving an influence of catecholamines on adrenal steroids. These findings could have implications for the cardiovascular complications of PPGLs and the clinical management of patients with the tumors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa423","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T18:04:51Z","timestamp":1593626691000},"page":"e3374-e3383","source":"Crossref","is-referenced-by-count":32,"title":["Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-2557","authenticated-orcid":false,"given":"Georgiana","family":"Constantinescu","sequence":"first","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Langton","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catleen","family":"Conrad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-4276","authenticated-orcid":false,"given":"Laurence","family":"Amar","sequence":"additional","affiliation":[{"name":"H\u00f4pital Europ\u00e9en Georges Pompidou, Hypertension Unit, APHP, Paris, France"},{"name":"Cardiovascular Research Center INSERM, Paris, France"},{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-0906","authenticated-orcid":false,"given":"Guillaume","family":"Assi\u00e9","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Department of Endocrinology, Center for Rare Adrenal Diseases, H\u00f4pital Cochin, APHP, Paris, France"},{"name":"Institut Cochin, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-670X","authenticated-orcid":false,"given":"Anne-Paule","family":"Gimenez-Roqueplo","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center INSERM, Paris, France"},{"name":"H\u00f4pital Europ\u00e9en Georges Pompidou, Genetics Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-0586","authenticated-orcid":false,"given":"Anne","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"INSERM, Centre d\u2019Investigations Cliniques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper K","family":"Larsen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-1116","authenticated-orcid":false,"given":"Paolo","family":"Mulatero","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-6444","authenticated-orcid":false,"given":"Tracy Ann","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy"},{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-0244","authenticated-orcid":false,"given":"Aleksander","family":"Prejbisz","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Institute of Cardiology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-6398","authenticated-orcid":false,"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Comprehensive Cancer Center Mainfranken, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King\u2019s College London, London, UK"},{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische Ern\u00e4hrung, University Hospital, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-8716","authenticated-orcid":false,"given":"Filippo","family":"Ceccato","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medicine DIMED, Padova University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-8196","authenticated-orcid":false,"given":"Stephanie","family":"Fliedner","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-6520","authenticated-orcid":false,"given":"Michael","family":"Dennedy","sequence":"additional","affiliation":[{"name":"The Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-675X","authenticated-orcid":false,"given":"Mirko","family":"Peitzsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-222X","authenticated-orcid":false,"given":"Richard","family":"Sinnott","sequence":"additional","affiliation":[{"name":"School of Computing and Information Systems, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-250X","authenticated-orcid":false,"given":"Andrzej","family":"Januszewicz","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Institute of Cardiology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-3984","authenticated-orcid":false,"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische Ern\u00e4hrung, University Hospital, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-9191","authenticated-orcid":false,"given":"Maria-Christina","family":"Zennaro","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center INSERM, Paris, France"},{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"H\u00f4pital Europ\u00e9en Georges Pompidou, Genetics Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-9903","authenticated-orcid":false,"given":"Graeme","family":"Eisenhofer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-1986","authenticated-orcid":false,"given":"Jaap","family":"Deinum","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"2","key":"2021122203125643200_CIT0001","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3803\/EnM.2017.32.2.152","article-title":"Update on modern management of pheochromocytoma and paraganglioma","volume":"32","author":"Lenders","year":"2017","journal-title":"Endocrinol Metab (Seoul)."},{"issue":"1","key":"2021122203125643200_CIT0002","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/HJH.0000000000000415","article-title":"The hypertension of Cushing\u2019s syndrome: controversies in the pathophysiology and focus on cardiovascular complications","volume":"33","author":"Isidori","year":"2015","journal-title":"J Hypertens."},{"issue":"3702","key":"2021122203125643200_CIT0003","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.150.3702.1464","article-title":"Adrenaline synthesis: control by the pituitary gland and adrenal glucocorticoids","volume":"150","author":"Wurtman","year":"1965","journal-title":"Science."},{"issue":"9","key":"2021122203125643200_CIT0004","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1002\/ijc.28868","article-title":"Opposing effects of HIF1\u03b1 and HIF2\u03b1 on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X","volume":"135","author":"Qin","year":"2014","journal-title":"Int J Cancer."},{"issue":"4","key":"2021122203125643200_CIT0005","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000126685","article-title":"Sympathoadrenal regulation of adrenal androstenedione release","volume":"59","author":"Ehrhart-Bornstein","year":"1994","journal-title":"Neuroendocrinology."},{"issue":"1-2","key":"2021122203125643200_CIT0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/07435809509030417","article-title":"Sympathoadrenal regulation of adrenocortical steroidogenesis","volume":"21","author":"Ehrhart-Bornstein","year":"1995","journal-title":"Endocr Res."},{"issue":"6-7","key":"2021122203125643200_CIT0007","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-2007-978911","article-title":"Neuroendocrine properties of adrenocortical cells","volume":"30","author":"Ehrhart-Bornstein","year":"1998","journal-title":"Horm Metab Res."},{"issue":"5","key":"2021122203125643200_CIT0008","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1530\/EJE-13-0308","article-title":"Autocrine\/paracrine regulatory mechanisms in adrenocortical neoplasms responsible for primary adrenal hypercorticism","volume":"169","author":"Lefebvre","year":"2013","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2021122203125643200_CIT0009","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1677\/joe.0.1350229","article-title":"Regulation of adrenal steroidogenesis by adrenaline: expression of cytochrome P450 genes","volume":"135","author":"G\u00fcse-Behling","year":"1992","journal-title":"J Endocrinol."},{"issue":"1","key":"2021122203125643200_CIT0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/eje.0.1350019","article-title":"Sympathoadrenal system and immune system in the regulation of adrenocortical function","volume":"135","author":"Ehrhart-Bornstein","year":"1996","journal-title":"Eur J Endocrinol."},{"key":"2021122203125643200_CIT0011","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1196\/annals.1410.053","article-title":"Cross-talk between adrenal medulla and adrenal cortex in stress","volume":"1148","author":"Ehrhart-Bornstein","year":"2008","journal-title":"Ann N Y Acad Sci."},{"issue":"6","key":"2021122203125643200_CIT0012","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122203125643200_CIT0013","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122203125643200_CIT0014","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing\u2019s syndrome: an endocrine society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122203125643200_CIT0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jsbmb.2014.10.006","article-title":"An LC-MS\/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism","volume":"145","author":"Peitzsch","year":"2015","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"Pt 2","key":"2021122203125643200_CIT0016","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1258\/acb.2012.012112","article-title":"Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma","volume":"50","author":"Peitzsch","year":"2013","journal-title":"Ann Clin Biochem."},{"key":"2021122203125643200_CIT0017","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cca.2012.12.031","article-title":"Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites","volume":"418","author":"Peitzsch","year":"2013","journal-title":"Clin Chim Acta."},{"key":"2021122203125643200_CIT0018","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2018.12.019","article-title":"Reference intervals for LC-MS\/MS measurements of plasma free, urinary free and urinary acid-hydrolyzed deconjugated normetanephrine, metanephrine and methoxytyramine","volume":"490","author":"Eisenhofer","year":"2019","journal-title":"Clin Chim Acta."},{"key":"2021122203125643200_CIT0019","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2017.05.002","article-title":"Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS\/MS: impact of gender, age, oral contraceptives, body mass index and blood pressure status","volume":"470","author":"Eisenhofer","year":"2017","journal-title":"Clin Chim Acta."},{"issue":"10","key":"2021122203125643200_CIT0020","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1210\/jc.2018-02349","article-title":"Plasma steroid profiles in subclinical compared with overt adrenal Cushing syndrome","volume":"104","author":"Masjkur","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122203125643200_CIT0021","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa423","article-title":"Glucocorticoid excess in patients with pheochromocytoma compared with paraganglioma and other forms of hypertension","volume-title":"Opara Repository","author":"Constantinescu","year":"2020"},{"issue":"3","key":"2021122203125643200_CIT0022","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1373\/clinchem.2017.282582","article-title":"Plasma steroid metabolome profiling for diagnosis and subtyping patients with Cushing syndrome","volume":"64","author":"Eisenhofer","year":"2018","journal-title":"Clin Chem."},{"issue":"2","key":"2021122203125643200_CIT0023","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/edrv.19.2.0326","article-title":"Intraadrenal interactions in the regulation of adrenocortical steroidogenesis","volume":"19","author":"Ehrhart-Bornstein","year":"1998","journal-title":"Endocr Rev."},{"issue":"2","key":"2021122203125643200_CIT0024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1385\/EP:16:2:091","article-title":"Cortical-chromaffin cell interactions in the adrenal gland","volume":"16","author":"Schinner","year":"2005","journal-title":"Endocr Pathol."},{"issue":"6","key":"2021122203125643200_CIT0025","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1507\/endocrj.50.739","article-title":"A case of ACTH-producing pheochromocytoma associated with pregnancy","volume":"50","author":"Oh","year":"2003","journal-title":"Endocr J."},{"issue":"7","key":"2021122203125643200_CIT0026","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ejim.2009.08.002","article-title":"ACTH-producing pheochromocytoma: clinical considerations and concise review of the literature","volume":"20","author":"Nijhoff","year":"2009","journal-title":"Eur J Intern Med."},{"issue":"1","key":"2021122203125643200_CIT0027","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/09513590.2017.1379497","article-title":"Hypertensive crisis in pregnancy due to a metamorphosing pheochromocytoma with postdelivery Cushing\u2019s syndrome","volume":"34","author":"Langton","year":"2018","journal-title":"Gynecol Endocrinol."},{"issue":"7","key":"2021122203125643200_CIT0028","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF03343608","article-title":"Pheochromocytoma and sub-clinical Cushing\u2019s syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy","volume":"22","author":"Finkenstedt","year":"1999","journal-title":"J Endocrinol Invest."},{"issue":"7","key":"2021122203125643200_CIT0029","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1442-2042.2011.02759.x","article-title":"Pheochromocytoma and subclinical Cushing\u2019s syndrome with focal adrenocortical hyperplasia","volume":"18","author":"Takizawa","year":"2011","journal-title":"Int J Urol."},{"issue":"3","key":"2021122203125643200_CIT0030","first-page":"CS34","article-title":"Severe postoperative hypoglycemia in a patient with pheochromocytoma and preclinical Cushing\u2019s syndrome","volume":"13","author":"Kastelan","year":"2007","journal-title":"Med Sci Monit."},{"issue":"2","key":"2021122203125643200_CIT0031","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/iju.13864","article-title":"Incidence and predictive factors of hypoglycemia after pheochromocytoma resection","volume":"26","author":"Araki","year":"2019","journal-title":"Int J Urol."},{"issue":"2","key":"2021122203125643200_CIT0032","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0950-3552(97)80035-1","article-title":"A critical review of the origin and control of adrenal androgens","volume":"11","author":"McKenna","year":"1997","journal-title":"Baillieres Clin Obstet Gynaecol."},{"issue":"2","key":"2021122203125643200_CIT0033","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s12020-014-0387-7","article-title":"DHEAS for the prediction of subclinical Cushing\u2019s syndrome: perplexing or advantageous?","volume":"48","author":"Yener","year":"2015","journal-title":"Endocrine."},{"issue":"7","key":"2021122203125643200_CIT0034","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/ERC-20-0102","article-title":"Mass spectrometry-based steroid profiling in primary bilateral macronodular adrenocortical hyperplasia","volume":"27","author":"Hannah-Shmouni","year":"2020","journal-title":"Endocr Relat Cancer."},{"issue":"3","key":"2021122203125643200_CIT0035","first-page":"786","article-title":"Low DHEAS: a sensitive and specific test for the detection of subclinical hypercortisolism in adrenal incidentalomas","volume":"102","author":"Dennedy","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"issue":"21","key":"2021122203125643200_CIT0036","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1073\/pnas.80.21.6728","article-title":"Direct stimulation of beta 2-adrenergic receptors in rat anterior pituitary induces the release of adrenocorticotropin in vivo","volume":"80","author":"Mezey","year":"1983","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2021122203125643200_CIT0037","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1440-1681.1987.tb00980.x","article-title":"Dissociation between corticotrophin and catecholamine responses to isoprenaline in humans","volume":"14","author":"Eisenhofer","year":"1987","journal-title":"Clin Exp Pharmacol Physiol."},{"issue":"8","key":"2021122203125643200_CIT0038","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight."},{"issue":"12","key":"2021122203125643200_CIT0039","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2018-00617","article-title":"Cortisol excess in patients with primary aldosteronism impacts left ventricular hypertrophy","volume":"103","author":"Adolf","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122203125643200_CIT0040","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2337\/dc18-1293","article-title":"High prevalence of diabetes in patients with primary aldosteronism (PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than unilateral PA: a large, multicenter cohort study in Japan","volume":"42","author":"Akehi","year":"2019","journal-title":"Diabetes Care."},{"issue":"1","key":"2021122203125643200_CIT0041","first-page":"117","article-title":"Incidence and late prognosis of Cushing\u2019s syndrome: a population-based study","volume":"86","author":"Lindholm","year":"2001","journal-title":"J Clin Endocrinol Metab."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa423\/33565317\/dgaa423.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/9\/e3374\/41847471\/jcem_105_9_e3374.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/9\/e3374\/41847471\/jcem_105_9_e3374.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T03:15:34Z","timestamp":1640142934000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/9\/e3374\/5866040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,7,1]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa423","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,7,1]]}}}