{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:20Z","timestamp":1790035220242,"version":"4.0.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Ministry of Education and Science","award":["BMBF"],"award-info":[{"award-number":["BMBF"]}]},{"name":"German Ministry of Education and Science","award":["0313826A"],"award-info":[{"award-number":["0313826A"]}]},{"name":"German Ministry of Education and Science","award":["0313826B"],"award-info":[{"award-number":["0313826B"]}]},{"name":"German Institute of Human Nutrition"},{"name":"Charit\u00e9 University Medicine Berlin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The human amylase gene (AMY1) has a broad copy number (CN) variation that may associate with body mass index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Deoxyribonucleic acid was extracted from urine (n\u2005=\u200574) and serum (n\u2005=\u20056) samples (Protein, Fiber and Metabolic Syndrome [ProFiMet] cohort), and buccal (n\u2005=\u200517) samples (Oral Starch Challenge [OSC] cohort), and assessed for AMY1 CN by droplet digital polymerase chain reaction. The association of AMY1 CN with comprehensive markers of metabolic status (ProFiMet cohort) were analyzed with Pearson\u2019s correlation coefficient (CC). For the healthy, euglycemic OSC cohort, glycemic response to OSC was analyzed with independent sample t-tests (subgroups: high AMY1 CN 9\u201312, n\u2005=\u200510; low AMY1 CN 4\u20136, n\u2005=\u20057).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were significant inverse correlations of AMY1 CN with total visceral fat volume (CC -0.33; P\u2005=\u20050.004) and positive correlations of AMY1 CN with oral glucose insulin sensitivity score (derived from an oral glucose tolerance test, CC 0.26; P\u2005=\u20050.02), serum HDL-cholesterol (CC 0.325; P\u2005=\u20050.003), and serum adiponectin (CC 0.249; P\u2005=\u20050.026). Linear regression multivariate analysis (adiponectin as dependent variable), showed independent association of adiponectin with AMY1 CN (Beta\u2005=\u20050.29; P\u2005=\u20050.03). There were no significant associations between AMY1 CN and clamp-derived M-value, homeostasis model assessment of insulin resistance (IR), hepatic endogenous glucose production, fecal floral signature, or macronutrient dietary preference. Delta (mean) change in blood glucose concentration (fasting to 30-minutes post-OSC) was significantly greater in the high versus low AMY1 CN subgroups (mean 1.7 mmol\/l [SEM 0.6] vs 0.9 mmol\/l [SEM 0.9], respectively; P\u2005=\u20050.016).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High AMY1 CN associates with a favorable metabolic profile (lower visceral fat volume, higher serum adiponectin, enhanced glucose absorption following oral glucose, and OSC), but not with whole-body or hepatic IR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa473","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T17:28:55Z","timestamp":1595438935000},"page":"e3586-e3596","source":"Crossref","is-referenced-by-count":20,"title":["<i>AMY1<\/i> Gene Copy Number Correlates With Glucose Absorption and Visceral Fat Volume, but Not with Insulin Resistance"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-9195","authenticated-orcid":false,"given":"Thomas M","family":"Barber","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK"},{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan A","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J D","family":"Elder","sequence":"additional","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah P","family":"Ball","sequence":"additional","affiliation":[{"name":"Micropathology Ltd., University of Warwick Science Park, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Calvez","sequence":"additional","affiliation":[{"name":"Micropathology Ltd., University of Warwick Science Park, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Ramsden","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, Medical School, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"Department of Obesity and Endocrinology; Clinical Sciences Centre, University Hospital Aintree, Liverpool, 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