{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:26:07Z","timestamp":1777332367674,"version":"3.51.4"},"reference-count":50,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["407440_167376"],"award-info":[{"award-number":["407440_167376"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wissenschaft & Weiterbildung Fonds","award":["140.000.495"],"award-info":[{"award-number":["140.000.495"]}]},{"name":"Hugo und Elsa Isner Foundation"},{"name":"Argovian Department of Health and Social Affairs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Patients with hypopituitarism face excess mortality in the long-term outpatient setting. However, associations of pituitary dysfunction with outcomes in acutely hospitalized patients are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this work is to assess clinical outcomes of hospitalized patients with hypopituitarism with or without diabetes insipidus (DI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, and Patients<\/jats:title>\n                  <jats:p>In this population-based, matched-cohort study from 2012 to 2017, hospitalized adult patients with a history of hypopituitarism were 1:1 propensity score\u2013matched with a general medical inpatient cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>The primary outcome was in-hospital mortality. Secondary outcomes included all-cause readmission rates within 30 days and 1 year, intensive care unit (ICU) admission rates, and length of hospital stay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After matching, 6764 cases were included in the study. In total, 3382 patients had hypopituitarism and of those 807 (24%) suffered from DI. All-cause in-hospital mortality occurred in 198 (5.9%) of patients with hypopituitarism and in 164 (4.9%) of matched controls (odds ratio [OR] 1.32, [95% CI, 1.06-1.65], P\u2005=\u2005.013). Increased mortality was primarily observed in patients with DI (OR 3.69 [95% CI, 2.44-5.58], P\u2005&amp;lt;\u2005.001). Patients with hypopituitarism had higher ICU admissions (OR 1.50 [95% CI, 1.30-1.74], P\u2005&amp;lt;\u2005.001), and faced a 2.4-day prolonged length of hospitalization (95% CI, 1.94\u20132.95, P\u2005&amp;lt;\u2005.001) compared to matched controls. Risk of 30-day (OR 1.31 [95% CI, 1.13-1.51], P\u2005&amp;lt;\u2005.001) and 1-year readmission (OR 1.29 [95% CI, 1.17-1.42], P\u2005&amp;lt;\u2005.001) was higher among patients with hypopituitarism as compared with medical controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with hypopituitarism are highly vulnerable once hospitalized for acute medical conditions with increased risk of mortality and adverse clinical outcomes. This was most pronounced among those with DI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa517","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T01:46:39Z","timestamp":1597283199000},"page":"e3910-e3918","source":"Crossref","is-referenced-by-count":23,"title":["Excess Mortality Among Hospitalized Patients With Hypopituitarism\u2014A Population-Based, Matched-Cohort Study"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-966X","authenticated-orcid":false,"given":"Fahim","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland"},{"name":"University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kutz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Division of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Wagner","sequence":"additional","affiliation":[{"name":"Foundation National Institute for Cancer Epidemiology and Registration (NICER) University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Illigens","sequence":"additional","affiliation":[{"name":"Division of Health Care Sciences Center for Clinical Research and Management Education Dresden, Dresden International University, Dresden, Germany"},{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Siepmann","sequence":"additional","affiliation":[{"name":"Division of Health Care Sciences Center for Clinical Research and Management Education Dresden, Dresden International University, Dresden, Germany"},{"name":"Department of Neurology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Division of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Division of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel R","family":"Christ","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"issue":"10058","key":"2021122106045190000_CIT0001","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/S0140-6736(16)30053-8","article-title":"Hypopituitarism","volume":"388","author":"Higham","year":"2016","journal-title":"Lancet."},{"issue":"23","key":"2021122106045190000_CIT0002","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJM199406093302306","article-title":"Hypopituitarism","volume":"330","author":"Vance","year":"1994","journal-title":"N Engl J Med."},{"issue":"2","key":"2021122106045190000_CIT0003","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11102-018-0869-3","article-title":"Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas","volume":"21","author":"Ntali","year":"2018","journal-title":"Pituitary."},{"issue":"9","key":"2021122106045190000_CIT0004","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1210\/jc.2010-0537","article-title":"Incidence of pituitary adenomas in Northern Finland in 1992-2007","volume":"95","author":"Raappana","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021122106045190000_CIT0005","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12020-013-0127-4","article-title":"Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database","volume":"47","author":"Tanriverdi","year":"2014","journal-title":"Endocrine."},{"issue":"4","key":"2021122106045190000_CIT0006","first-page":"1420","article-title":"Pituitary adenomas in Sweden between 1958 and 1991: incidence, survival, and mortality","volume":"85","author":"Nilsson","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"7","key":"2021122106045190000_CIT0007","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1210\/jc.2015-1475","article-title":"Excess mortality in women and young adults with nonfunctioning pituitary adenoma: a Swedish nationwide study","volume":"100","author":"Olsson","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122106045190000_CIT0008","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11102-016-0764-8","article-title":"Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study","volume":"20","author":"Olsson","year":"2017","journal-title":"Pituitary."},{"issue":"2","key":"2021122106045190000_CIT0009","doi-asserted-by":"crossref","first-page":"101276","DOI":"10.1016\/j.beem.2019.04.010","article-title":"New causes of hypophysitis","volume":"33","author":"Yuen","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"9","key":"2021122106045190000_CIT0010","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41571-019-0218-0","article-title":"Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance","volume":"16","author":"Martins","year":"2019","journal-title":"Nat Rev Clin Oncol."},{"issue":"2","key":"2021122106045190000_CIT0011","doi-asserted-by":"crossref","first-page":"101309","DOI":"10.1016\/j.beem.2019.101309","article-title":"The burden of disease for pituitary patients","volume":"33","author":"Biermasz","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"3","key":"2021122106045190000_CIT0012","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1210\/er.2009-0033","article-title":"Mortality in patients with pituitary disease","volume":"31","author":"Sherlock","year":"2010","journal-title":"Endocr Rev."},{"issue":"9254","key":"2021122106045190000_CIT0013","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet."},{"issue":"1","key":"2021122106045190000_CIT0014","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12020-016-1159-3","article-title":"Mortality in adults with hypopituitarism: a systematic review and meta-analysis","volume":"56","author":"Jasim","year":"2017","journal-title":"Endocrine."},{"issue":"4","key":"2021122106045190000_CIT0015","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1210\/jc.2014-3787","article-title":"Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies","volume":"100","author":"Pappachan","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122106045190000_CIT0016","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1530\/EC-18-0096","article-title":"The prevalence of the metabolic syndrome and associated cardiovascular complications in adult-onset GHD during GH replacement: a KIMS analysis","volume":"7","author":"Verhelst","year":"2018","journal-title":"Endocr Connect."},{"issue":"6","key":"2021122106045190000_CIT0017","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11102-016-0747-9","article-title":"Sex differences in the prevalence of metabolic syndrome and its components in hypopituitary patients: comparison with an age- and sex-matched nationwide control group","volume":"19","author":"Khang","year":"2016","journal-title":"Pituitary."},{"key":"2021122106045190000_CIT0018","volume-title":"Regeln und Definitionen zur Fallabrechnung unter SwissDRG.","author":"SwissDRG"},{"key":"2021122106045190000_CIT0019","article-title":"Supplementary appendix: excess mortality among hospitalized patients with hypopituitarism\u2014A population based matched cohort study.","author":"Ebrahimi","journal-title":"Mendeley Data."},{"issue":"12","key":"2021122106045190000_CIT0020","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies","volume":"12","author":"von Elm","year":"2014","journal-title":"Int J Surg."},{"issue":"3","key":"2021122106045190000_CIT0021","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1210\/jc.2012-2684","article-title":"Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients","volume":"98","author":"Hartman","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122106045190000_CIT0022","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis."},{"issue":"6","key":"2021122106045190000_CIT0023","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1080\/03610910902859574","article-title":"Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research","volume":"38","author":"Austin","year":"2009","journal-title":"Commun Stat Simul Comput."},{"issue":"12","key":"2021122106045190000_CIT0024","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1210\/jc.2016-2221","article-title":"Exploring inpatient hospitalizations and morbidity in patients with adrenal insufficiency","volume":"101","author":"Stewart","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021122106045190000_CIT0025","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1210\/jc.2006-0524","article-title":"The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients","volume":"91","author":"Filipsson","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122106045190000_CIT0026","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1530\/EJE-08-0874","article-title":"Inadequacies of glucocorticoid replacement and improvements by physiological circadian therapy","volume":"160","author":"Debono","year":"2009","journal-title":"Eur J Endocrinol."},{"issue":"7","key":"2021122106045190000_CIT0027","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5694\/j.1326-5377.2008.tb01686.x","article-title":"Management of adrenal insufficiency during the stress of medical illness and surgery","volume":"188","author":"Jung","year":"2008","journal-title":"Med J Aust."},{"issue":"6","key":"2021122106045190000_CIT0028","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1530\/EJE-19-0469","article-title":"Association of adrenal insufficiency with patient-oriented health-care outcomes in adult medical inpatients","volume":"181","author":"Ebrahimi","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2021122106045190000_CIT0029","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ccc.2018.11.001","article-title":"Diabetes insipidus and syndrome of inappropriate antidiuretic hormone in critically ill patients","volume":"35","author":"Harrois","year":"2019","journal-title":"Crit Care Clin."},{"issue":"8","key":"2021122106045190000_CIT0030","doi-asserted-by":"crossref","first-page":"e016248","DOI":"10.1136\/bmjopen-2017-016248","article-title":"The association between intensive care unit-acquired hypernatraemia and mortality in critically ill patients with cerebrovascular diseases: a single-centre cohort study in Japan","volume":"7","author":"Imaizumi","year":"2017","journal-title":"BMJ Open."},{"issue":"6","key":"2021122106045190000_CIT0031","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1053\/j.ajkd.2007.08.016","article-title":"Hypernatremia in the critically ill is an independent risk factor for mortality","volume":"50","author":"Lindner","year":"2007","journal-title":"Am J Kidney Dis."},{"issue":"8","key":"2021122106045190000_CIT0032","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/ndt\/gfq067","article-title":"Association between hypernatraemia acquired in the ICU and mortality: a cohort study","volume":"25","author":"Darmon","year":"2010","journal-title":"Nephrol Dial Transplant."},{"issue":"2","key":"2021122106045190000_CIT0033","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/jc.2014-3525","article-title":"Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood onset: a population-based study in Sweden","volume":"100","author":"Olsson","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021122106045190000_CIT0034","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2017.7.FOCUS17418","article-title":"Morbidity and mortality associated with hypernatremia in patients with severe traumatic brain injury","volume":"43","author":"Vedantam","year":"2017","journal-title":"Neurosurg Focus."},{"key":"2021122106045190000_CIT0035","article-title":"Management of central diabetes insipidus.","author":"Garrahy","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"12","key":"2021122106045190000_CIT0036","first-page":"CD002243","article-title":"Corticosteroids for treating sepsis","volume":"2015","author":"Annane","year":"2015","journal-title":"Cochrane Database Syst Rev."},{"issue":"3","key":"2021122106045190000_CIT0037","first-page":"341","article-title":"Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level","volume":"29","author":"Katan","year":"2008","journal-title":"Neuro Endocrinol Lett."},{"issue":"7","key":"2021122106045190000_CIT0038","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1210\/jc.2006-2046","article-title":"Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay","volume":"92","author":"Katan","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021122106045190000_CIT0039","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1210\/jc.2007-0232","article-title":"Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects","volume":"92","author":"Szinnai","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021122106045190000_CIT0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2362.2007.01762.x","article-title":"Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections","volume":"37","author":"M\u00fcller","year":"2007","journal-title":"Eur J Clin Invest."},{"issue":"14","key":"2021122106045190000_CIT0041","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1212\/WNL.0b013e3182887944","article-title":"Copeptin adds prognostic information after ischemic stroke: results from the CoRisk study","volume":"80","author":"De Marchis","year":"2013","journal-title":"Neurology."},{"issue":"4","key":"2021122106045190000_CIT0042","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1210\/jc.2006-1487","article-title":"A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults","volume":"92","author":"G\u00f6therstr\u00f6m","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021122106045190000_CIT0043","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1210\/jcem.86.10.7887","article-title":"A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices","volume":"86","author":"G\u00f6therstr\u00f6m","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122106045190000_CIT0044","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1210\/jcem.87.3.8336","article-title":"The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study","volume":"87","author":"Colao","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021122106045190000_CIT0045","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1210\/jc.2011-1215","article-title":"Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults","volume":"96","author":"van Bunderen","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021122106045190000_CIT0046","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1530\/EJE-11-1028","article-title":"Overall and cause-specific mortality in GH-deficient adults on GH replacement","volume":"166","author":"Gaillard","year":"2012","journal-title":"Eur J Endocrinol."},{"issue":"11","key":"2021122106045190000_CIT0047","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1056\/NEJM199909093411102","article-title":"Increased mortality associated with growth hormone treatment in critically ill adults","volume":"341","author":"Takala","year":"1999","journal-title":"N Engl J Med."},{"issue":"2","key":"2021122106045190000_CIT0048","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.metabol.2006.09.020","article-title":"Frequency and outcome of patients with nonthyroidal illness syndrome in a medical intensive care unit","volume":"56","author":"Plikat","year":"2007","journal-title":"Metabolism."},{"issue":"2","key":"2021122106045190000_CIT0049","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccc.2018.11.012","article-title":"Thyroid hormones in critical illness","volume":"35","author":"Maiden","year":"2019","journal-title":"Crit Care Clin."},{"issue":"1","key":"2021122106045190000_CIT0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ccc.2005.08.005","article-title":"Gonadal steroids in critical illness","volume":"22","author":"Mechanick","year":"2006","journal-title":"Crit Care Clin."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa517\/33645460\/dgaa517.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/11\/e3910\/41827955\/dgaa517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/11\/e3910\/41827955\/dgaa517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T06:06:56Z","timestamp":1640066816000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/11\/e3910\/5891746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,8,12]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa517","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,8,12]]}}}