{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:44:47Z","timestamp":1782794687428,"version":"3.54.5"},"reference-count":45,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>In primary aldosteronism, cosecretion of cortisol may alter cortisol-derived adrenal venous sampling indices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To identify whether cortisol cosecretion in primary aldosteronism alters adrenal venous sampling parameters and interpretation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective case\u2013control study<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A tertiary referral center<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>144 adult patients with primary aldosteronism who had undergone both adrenocorticotropic hormone-stimulated adrenal venous sampling and dexamethasone suppression testing between 2004 and 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Adrenal venous sampling indices including adrenal vein aldosterone\/cortisol ratios and the selectivity, lateralization, and contralateral suppression indices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>21 (14.6%) patients had evidence of cortisol cosecretion (defined as a failure to suppress cortisol to \u226450 nmol\/L post dexamethasone). Patients with evidence of cortisol cosecretion had a higher inferior vena cava cortisol concentration (P\u2005=\u2005.01) than those without. No difference was observed between the groups in terms of selectivity index, lateralization index, lateralization of aldosterone excess, or adrenal vein cannulation rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cortisol cosecretion alters some parameters in adrenocorticotrophic hormone-stimulated adrenal venous sampling but does not result in alterations in patient management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa519","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T18:12:45Z","timestamp":1599156765000},"page":"e3776-e3784","source":"Crossref","is-referenced-by-count":35,"title":["Low-grade Cortisol Cosecretion Has Limited Impact on ACTH-stimulated AVS Parameters in Primary Aldosteronism"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-8556","authenticated-orcid":false,"given":"Samuel Matthew","family":"O\u2019Toole","sequence":"first","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital, London, UK"},{"name":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Chiu Candy","family":"Sze","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Teng","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott 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