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Associations were strongest among those who were overweight (not obese) at baseline, and among those with a history of cardiovascular disease (CVD) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improvements in glycemic control, but not necessarily weight status, during ILI may be associated with better subsequent cognitive performance. These associations may differ by adiposity and CVD history.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgaa591","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T18:57:12Z","timestamp":1598468232000},"page":"e4778-e4791","source":"Crossref","is-referenced-by-count":24,"title":["Long-term Change in Physiological Markers and Cognitive Performance in Type 2 Diabetes: The Look AHEAD Study"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-0047","authenticated-orcid":false,"given":"Owen T","family":"Carmichael","sequence":"first","affiliation":[{"name":"Biomedical Imaging Center, Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca H","family":"Neiberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth R","family":"Dutton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Hayden","sequence":"additional","affiliation":[{"name":"Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Horton","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Xavier","family":"Pi-Sunyer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Obesity\/Nutrition Research Center, Columbia University College of Physicians and Surgeons, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"Spira","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Espeland","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"issue":"1","key":"2021122201020145500_CIT0001","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jval.2016.08.735","article-title":"The burden of obesity on diabetes in the United States: medical expenditure panel survey, 2008 to 2012","volume":"20","author":"Leung","year":"2017","journal-title":"Value Health."},{"issue":"12","key":"2021122201020145500_CIT0002","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1111\/jgs.12035","article-title":"Diabetes in older adults: a consensus report","volume":"60","author":"Kirkman","year":"2012","journal-title":"J Am Geriatr Soc."},{"issue":"3","key":"2021122201020145500_CIT0003","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2337\/dc08-9017","article-title":"Economic costs of diabetes in the US in 2007","volume":"31","author":"Association AD","year":"2008","journal-title":"Diabetes Care."},{"issue":"9","key":"2021122201020145500_CIT0004","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1056\/NEJM199508313330902","article-title":"Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus","volume":"333","author":"DeFronzo","year":"1995","journal-title":"N. 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