{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:25:50Z","timestamp":1783488350338,"version":"3.55.0"},"reference-count":53,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Lombardia Region","award":["XI\/2014\/31.07.2019"],"award-info":[{"award-number":["XI\/2014\/31.07.2019"]}]},{"name":"IRCCS San Raffaele-Neonatology Unit","award":["E10A2181"],"award-info":[{"award-number":["E10A2181"]}]},{"name":"Ricerca Corrente funds of Istituto Auxologico Italiano","award":["05C002_2010"],"award-info":[{"award-number":["05C002_2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Analysis of a 2-screen program for congenital hypothyroidism (CH) was performed using differential dried-blood spot thyrotropin (bTSH) cutoffs of 10 mU\/L at first screening (all infants) and 5 mU\/L at second screening (selected infants).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This work aimed to characterize CH infants identified by the second screening and compare infants with bTSH of 5.0 to 9.9 and 10 mU\/L or greater on second screening.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Patients<\/jats:title>\n                  <jats:p>Maternal and neonatal clinical features were retrospectively analyzed for 119 CH babies detected on the second screen in the Lombardy region of Italy, 2007 to 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-two (43.7%) of the 119 CH neonates showed bTSH values ranging from 5.0 to 9.9 mU\/L at the second screening (low bTSH group) and 67 (56.3%) bTSH of 10.0 mU\/L or greater (high bTSH group). The frequency of thyroid dysgenesis and eutopic gland was similar in both groups, as was the frequency of permanent and transient CH. Moreover, a high frequency of extrathyroidal malformations was found in both groups. The percentage of preterm infants (57.7% vs 23.9%, P\u2005&amp;lt;\u2005.001) and infants admitted to the neonatal intensive care unit (50.0% vs 17.9%, P\u2005&amp;lt;\u2005.001) was significantly higher in the low vs the high bTSH group. In addition, maternal treatment with glucocorticoids in pregnancy was significantly more frequent in the low bTSH group than in the high bTSH group (11.5% vs 1.5%, P\u2005=\u2005.042), as well as maternal hypothyroidism and\/or goiter (26.9% vs 10.4%, P\u2005=\u2005.036).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study has demonstrated that a lower TSH cutoff at the second screening can detect additional cases of CH and that a second bTSH cutoff of 5.0 mU\/L is appropriate for identifying preterm newborns and babies with associated risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa789","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T09:30:53Z","timestamp":1604050253000},"page":"e338-e349","source":"Crossref","is-referenced-by-count":26,"title":["Newborn Screening for Congenital Hypothyroidism: the Benefit of Using Differential TSH Cutoffs in a 2-Screen Program"],"prefix":"10.1210","volume":"106","author":[{"given":"Silvana","family":"Caiulo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Regional Newborn Screening Laboratory of Lombardy Region, Children\u2019s Hospital V. 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