{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:58:39Z","timestamp":1770361119314,"version":"3.49.0"},"reference-count":73,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The prevalence of vertebral deformities in long-term survivors of childhood acute lymphoblastic leukemia (ALL) is unknown. Our objectives were to identify the prevalence of vertebral deformities and their risk factors among long-term childhood ALL survivors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods\/Results<\/jats:title>\n                  <jats:p>We recruited 245 (49% male) long-term childhood ALL survivors from the Preventing Late Adverse Effects of Leukemia Cohort (French-Canadian ALL survivors treated between the years 1987 and 2010 with the Dana Farber Cancer Institute clinical trials protocols, who did not experience disease relapse and\/or receive hematopoietic stem cell transplant). Median age at recruitment was 21.7 years (range, 8.5-41) and median time since diagnosis was 15.1 years (range, 5.4-28.2). All participants underwent spine radiograph and dual-energy X-ray absorptiometry scans. The prevalence of vertebral deformity was 23% with 88% classified as grade 1 according to the Genant method. The majority of vertebral deformities were clinically silent. Regression analysis confirmed male sex (risk ratio [RR] = 1.94; 95% confidence interval [CI], 1.16-3.24; P = 0.011), higher glucocorticoid cumulative dose (RR = 1.05; 95% CI, 1.00-1.10; P = 0.032), and back pain (RR = 2.44; 95% CI, 1.56-3.84; P &amp;lt; 0.001) as predictors of prevalent vertebral deformity. Sex differences in vertebral deformity predictors emerged.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We report a significant prevalence of vertebral deformities in this young cohort. Male sex, cumulative glucocorticoid dose, and back pain were identified as predictors of prevalent vertebral deformity. Back pain emerging as a strong predictor of vertebral deformity underscores the importance of ongoing bone health surveillance in survivors with persistent vertebral deformities treated with these earlier protocols.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa806","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T04:04:18Z","timestamp":1604549058000},"page":"512-525","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of Vertebral Deformity in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia: The PETALE Study"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-0691","authenticated-orcid":false,"given":"Melissa","family":"Fiscaletti","sequence":"first","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariia","family":"Samoilenko","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-3028","authenticated-orcid":false,"given":"Jos\u00e9e","family":"Dubois","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6425-4785","authenticated-orcid":false,"given":"Marie-Claude","family":"Miron","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-8218","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-7031","authenticated-orcid":false,"given":"Maja","family":"Krajinovic","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-7152","authenticated-orcid":false,"given":"Caroline","family":"Laverdi\u00e8re","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-6676","authenticated-orcid":false,"given":"Daniel","family":"Sinnett","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Alos","sequence":"additional","affiliation":[{"name":"CHU Sainte Justine Mother and Child University Hospital Center (CHUSJ), Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"issue":"2","key":"2021122205483515800_CIT0001","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA Cancer J Clin."},{"key":"2021122205483515800_CIT0002","author":"Canadian Cancer Statistics Advisory Committee. 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