{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:26:36Z","timestamp":1778754396293,"version":"3.51.4"},"reference-count":42,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["28-6, 2019-B4"],"award-info":[{"award-number":["28-6, 2019-B4"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20ek0109373h0003"],"award-info":[{"award-number":["20ek0109373h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>(Epi)genetic disorders associated with small-for-gestational-age with short stature (SGA-SS) include imprinting disorders (IDs). Silver-Russell syndrome (SRS) is a representative ID in SGA-SS and has heterogenous (epi)genetic causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>To clarify the contribution of IDs to SGA-SS and the molecular and phenotypic spectrum of SRS, we recruited 269 patients with SGA-SS, consisting of 103 and 166 patients referred to us for genetic testing for SGA-SS and SRS, respectively. After excluding 20 patients with structural abnormalities detected by comparative genomic hybridization analysis using catalog array, 249 patients were classified into 3 subgroups based on the Netchine-Harbison clinical scoring system (NH-CSS), SRS diagnostic criteria. We screened various IDs by methylation analysis for differentially methylated regions (DMRs) related to known IDs. We also performed clinical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>These 249 patients with SGA-SS were classified into the \u201cSRS-compatible group\u201d (n = 148), the \u201cnon-SRS with normocephaly or relative macrocephaly at birth group\u201d (non-SRS group) (n = 94), or the \u201cnon-SRS with relative microcephaly at birth group\u201d (non-SRS with microcephaly group) (n = 7). The 44.6% of patients in the \u201cSRS-compatible group,\u201d 21.3% of patients in the \u201cnon-SRS group,\u201d and 14.3% in the \u201cnon-SRS with microcephaly group\u201d had various IDs. Loss of methylation of the H19\/IGF2:intergenic-DMR and uniparental disomy chromosome 7, being major genetic causes of SRS, was detected in 30.4% of patients in the \u201cSRS-compatible group\u201d and in 13.8% of patients in the \u201cnon-SRS group.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We clarified the contribution of IDs as (epi)genetic causes of SGA-SS and the molecular and phenotypic spectrum of SRS. Various IDs constitute underlying factors for SGA-SS, including SRS.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgaa856","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T08:46:53Z","timestamp":1606294013000},"page":"802-813","source":"Crossref","is-referenced-by-count":26,"title":["Role of Imprinting Disorders in Short Children Born SGA and Silver-Russell Syndrome Spectrum"],"prefix":"10.1210","volume":"106","author":[{"given":"Tomoko","family":"Fuke","sequence":"first","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akie","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"},{"name":"Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori Isono","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"},{"name":"Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Yamazawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"},{"name":"Medical Genetics Center, National Hospital Organization Tokyo Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-4035","authenticated-orcid":false,"given":"Maki","family":"Fukami","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-9991","authenticated-orcid":false,"given":"Tsutomu","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"},{"name":"Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3020-455X","authenticated-orcid":false,"given":"Masayo","family":"Kagami","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"issue":"6","key":"2021122117334500300_CIT0001","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2018-00083","article-title":"Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications","volume":"39","author":"Finken","year":"2018","journal-title":"Endocr Rev."},{"issue":"1","key":"2021122117334500300_CIT0002","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1687-9856-2012-11","article-title":"Early diagnosis and treatment referral of children born small for gestational age without catch-up growth are critical for optimal growth outcomes","volume":"2012","author":"Houk","year":"2012","journal-title":"Int J Pediatr Endocrinol."},{"issue":"3","key":"2021122117334500300_CIT0003","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1210\/jc.2017-01843","article-title":"Genetic analyses in small-for-gestational-age newborns","volume":"103","author":"Stalman","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122117334500300_CIT0004","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1210\/jc.2006-2017","article-title":"Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society","volume":"92","author":"Clayton","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"6 Pt 1","key":"2021122117334500300_CIT0005","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1542\/peds.111.6.1253","article-title":"International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24\u2013October 1, 2001","volume":"111","author":"Lee","year":"2003","journal-title":"Pediatrics."},{"issue":"4","key":"2021122117334500300_CIT0006","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41576-018-0092-0","article-title":"Genomic imprinting disorders: lessons on how genome, epigenome and environment interact","volume":"20","author":"Monk","year":"2019","journal-title":"Nat Rev Genet."},{"issue":"3","key":"2021122117334500300_CIT0007","doi-asserted-by":"crossref","first-page":"e60105","DOI":"10.1371\/journal.pone.0060105","article-title":"Molecular and clinical studies in 138 Japanese patients with Silver-Russell syndrome","volume":"8","author":"Fuke","year":"2013","journal-title":"PLoS One."},{"issue":"12","key":"2021122117334500300_CIT0008","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/gim.2017.53","article-title":"Temple syndrome: comprehensive molecular and clinical findings in 32 Japanese patients","volume":"19","author":"Kagami","year":"2017","journal-title":"Genet Med."},{"issue":"9","key":"2021122117334500300_CIT0009","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/jmedgenet-2017-105118","article-title":"Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome","volume":"55","author":"Singh","year":"2018","journal-title":"J Med Genet."},{"issue":"6","key":"2021122117334500300_CIT0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/jmedgenet-2018-105463","article-title":"Molecular and clinical analyses of two patients with UPD(16)mat detected by screening 94 patients with Silver-Russell syndrome phenotype of unknown aetiology","volume":"56","author":"Inoue","year":"2019","journal-title":"J Med Genet."},{"issue":"6","key":"2021122117334500300_CIT0011","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1210\/jc.2017-02780","article-title":"Maternal uniparental disomy for chromosome 20: physical and endocrinological characteristics of five patients","volume":"103","author":"Kawashima","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"7","key":"2021122117334500300_CIT0012","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jmedgenet-2014-102979","article-title":"A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome","volume":"52","author":"Azzi","year":"2015","journal-title":"J Med Genet."},{"issue":"2","key":"2021122117334500300_CIT0013","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrendo.2016.138","article-title":"Diagnosis and management of Silver-Russell syndrome: first international consensus statement","volume":"13","author":"Wakeling","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"2021122117334500300_CIT0014","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3389\/fgene.2019.00955","article-title":"Molecular etiology disclosed by array CGH in patients with Silver-Russell syndrome or similar phenotypes","volume":"10","author":"Crippa","year":"2019","journal-title":"Front Genet."},{"issue":"6","key":"2021122117334500300_CIT0015","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ejhg.2009.246","article-title":"Methylation analysis of 79 patients with growth restriction reveals novel patterns of methylation change at imprinted loci","volume":"18","author":"Turner","year":"2010","journal-title":"Eur J Hum Genet."},{"issue":"11","key":"2021122117334500300_CIT0016","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/jmg.2010.079343","article-title":"Parthenogenetic chimaerism\/mosaicism with a Silver-Russell syndrome-like phenotype","volume":"47","author":"Yamazawa","year":"2010","journal-title":"J Med Genet."},{"issue":"8","key":"2021122117334500300_CIT0017","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/jhg.2011.59","article-title":"Maternal age effect on the development of Prader-Willi syndrome resulting from upd(15)mat through meiosis 1 errors","volume":"56","author":"Matsubara","year":"2011","journal-title":"J Hum Genet."},{"issue":"1","key":"2021122117334500300_CIT0018","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13148-019-0640-2","article-title":"Temple syndrome in a patient with variably methylated CpGs at the primary MEG3\/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR","volume":"11","author":"Kagami","year":"2019","journal-title":"Clin Epigenetics."},{"issue":"2","key":"2021122117334500300_CIT0019","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/jhg.2014.100","article-title":"Silver-Russell syndrome without body asymmetry in three patients with duplications of maternally derived chromosome 11p15 involving CDKN1C","volume":"60","author":"Nakashima","year":"2015","journal-title":"J Hum Genet."},{"issue":"7","key":"2021122117334500300_CIT0020","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/ajmg.a.37679","article-title":"Silver-Russell syndrome in a patient with somatic mosaicism for upd(11)mat identified by buccal cell analysis","volume":"170","author":"Luk","year":"2016","journal-title":"Am J Med Genet A."},{"issue":"5","key":"2021122117334500300_CIT0021","doi-asserted-by":"crossref","first-page":"e929","DOI":"10.1542\/peds.2008-3228","article-title":"Broad clinical spectrum in Silver-Russell syndrome and consequences for genetic testing in growth retardation","volume":"123","author":"Eggermann","year":"2009","journal-title":"Pediatrics."},{"issue":"5","key":"2021122117334500300_CIT0022","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1586\/erm.12.43","article-title":"Epigenetic and genetic diagnosis of Silver-Russell syndrome","volume":"12","author":"Eggermann","year":"2012","journal-title":"Expert Rev Mol Diagn."},{"issue":"5","key":"2021122117334500300_CIT0023","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1086\/508902","article-title":"Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia","volume":"79","author":"Feuk","year":"2006","journal-title":"Am J Hum Genet."},{"issue":"2","key":"2021122117334500300_CIT0024","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/15592294.2014.998536","article-title":"DNA methylation abnormalities in congenital heart disease","volume":"10","author":"Serra-Juh\u00e9","year":"2015","journal-title":"Epigenetics."},{"issue":"1","key":"2021122117334500300_CIT0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/cge.12958","article-title":"Maternal uniparental disomy of chromosome 16 [upd(16)mat]: clinical features are rather caused by (hidden) trisomy 16 mosaicism than by upd(16)mat itself","volume":"92","author":"Scheuvens","year":"2017","journal-title":"Clin Genet."},{"issue":"2","key":"2021122117334500300_CIT0026","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1210\/jc.2008-1805","article-title":"Clinically distinct epigenetic subgroups in Silver-Russell syndrome: the degree of H19 hypomethylation associates with phenotype severity and genital and skeletal anomalies","volume":"94","author":"Bruce","year":"2009","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2021122117334500300_CIT0027","first-page":"837","article-title":"The spectrum of Silver-Russell syndrome: a clinical and molecular genetic study and new diagnostic criteria","volume":"36","author":"Price","year":"1999","journal-title":"J Med Genet."},{"issue":"9","key":"2021122117334500300_CIT0028","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/aje\/kwr421","article-title":"Cryptorchidism and hypospadias in a cohort of 934,538 Danish boys: the role of birth weight, gestational age, body dimensions, and fetal growth","volume":"175","author":"Jensen","year":"2012","journal-title":"Am J Epidemiol."},{"issue":"6","key":"2021122117334500300_CIT0029","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/jmg.2007.057059","article-title":"Mosaic maternal uniparental disomy of chromosome 11 in a patient with Silver-Russell syndrome","volume":"45","author":"Bullman","year":"2008","journal-title":"J Med Genet."},{"issue":"6","key":"2021122117334500300_CIT0030","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/ajmg.a.33398","article-title":"Chromosome 11p15 duplication in Silver-Russell syndrome due to a maternally inherited translocation t(11;15)","volume":"152A","author":"Eggermann","year":"2010","journal-title":"Am J Med Genet A."},{"issue":"5","key":"2021122117334500300_CIT0031","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1136\/jmg.2004.028936","article-title":"Is maternal duplication of 11p15 associated with Silver-Russell syndrome?","volume":"42","author":"Eggermann","year":"2005","journal-title":"J Med Genet."},{"issue":"3","key":"2021122117334500300_CIT0032","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ajmg.c.30274","article-title":"Russell-Silver syndrome","volume":"154C","author":"Eggermann","year":"2010","journal-title":"Am J Med Genet C Semin Med Genet."},{"issue":"1","key":"2021122117334500300_CIT0033","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.beem.2010.06.005","article-title":"Silver-Russell syndrome","volume":"25","author":"Binder","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"12","key":"2021122117334500300_CIT0034","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/jmedgenet-2013-101691","article-title":"CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell Silver syndrome","volume":"50","author":"Brioude","year":"2013","journal-title":"J Med Genet."},{"issue":"7","key":"2021122117334500300_CIT0035","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1210\/jc.2017-02152","article-title":"Chromosome 14q32.2 imprinted region disruption as an alternative molecular diagnosis of Silver-Russell syndrome","volume":"103","author":"Geoffron","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122117334500300_CIT0036","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13039-018-0411-3","article-title":"Maternal uniparental isodisomy for chromosome 6 discovered by paternity testing: a case report","volume":"11","author":"Kerr","year":"2018","journal-title":"Mol Cytogenet."},{"issue":"12","key":"2021122117334500300_CIT0037","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1002\/ajmg.a.37876","article-title":"Maternal uniparental disomy for chromosome 6 in a patient with IUGR, ambiguous genitalia, and persistent mullerian structures","volume":"170","author":"Lazier","year":"2016","journal-title":"Am J Med Genet A."},{"issue":"6","key":"2021122117334500300_CIT0038","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000345168","article-title":"Segmental maternal UPD6 with prenatal growth restriction","volume":"3","author":"Poke","year":"2013","journal-title":"Mol Syndromol."},{"issue":"10","key":"2021122117334500300_CIT0039","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00109-020-01966-z","article-title":"Need for a precise molecular diagnosis in Beckwith-Wiedemann and Silver-Russell syndrome: what has to be considered and why it is important","volume":"98","author":"Eggermann","year":"2020","journal-title":"J Mol Med (Berl)."},{"issue":"9","key":"2021122117334500300_CIT0040","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/ajmg.a.36049","article-title":"Targeted methylation testing of a patient cohort broadens the epigenetic and clinical description of imprinting disorders","volume":"161A","author":"Poole","year":"2013","journal-title":"Am J Med Genet A."},{"issue":"24","key":"2021122117334500300_CIT0041","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1093\/hmg\/ddp435","article-title":"Multilocus methylation analysis in a large cohort of 11p15-related foetal growth disorders (Russell Silver and Beckwith Wiedemann syndromes) reveals simultaneous loss of methylation at paternal and maternal imprinted loci","volume":"18","author":"Azzi","year":"2009","journal-title":"Hum Mol Genet."},{"issue":"1","key":"2021122117334500300_CIT0042","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1399-0004.2010.01514.x","article-title":"Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues","volume":"80","author":"Begemann","year":"2011","journal-title":"Clin Genet."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa856\/36212793\/dgaa856.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/3\/802\/41832612\/dgaa856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/3\/802\/41832612\/dgaa856.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:42:29Z","timestamp":1697226149000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/3\/802\/6000393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,11,24]]},"published-print":{"date-parts":[[2021,3,8]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa856","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,11,24]]}}}