{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:14:09Z","timestamp":1773306849069,"version":"3.50.1"},"reference-count":46,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Independent Research Fond Denmark","award":["6110-00187"],"award-info":[{"award-number":["6110-00187"]}]},{"name":"Region of Southern Denmark","award":["16\/13529"],"award-info":[{"award-number":["16\/13529"]}]},{"name":"Danish Medical Association Research fund","award":["2638669"],"award-info":[{"award-number":["2638669"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Individuals with type 2 diabetes have an increased risk of endothelial dysfunction and cardiovascular disease. Plasma aldosterone could contribute by reactive oxygen species\u2013dependent mechanisms by inducing a shift in the balance between a vasoconstrictor and vasodilator response to aldosterone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to investigate the acute vascular effects of aldosterone in individuals with type 2 diabetes compared with healthy controls and if infusion of an antioxidant (n-acetylcysteine [NAC]) would alter the vascular response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a case\u2013control design, 12 participants with type 2 diabetes and 14 healthy controls, recruited from the general community, were studied. Leg hemodynamics were measured before and during aldosterone infusion (0.2 and 5 ng min\u20131 [L leg volume]\u20131) for 10 minutes into the femoral artery with and without coinfusion of NAC (125 mg kg\u20131 hour\u20131 followed by 25 mg kg\u20131 hour\u20131). Leg blood flow and arterial blood pressure was measured, and femoral arterial and venous blood samples were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with the control group, leg blood flow and vascular conductance decreased during infusion of aldosterone at the high dose in individuals with type 2 diabetes, whereas coinfusion of NAC attenuated this response. Plasma aldosterone increased in both groups during aldosterone infusion and there was no difference between groups at baseline or during the infusions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results suggests that type 2 diabetes is associated with a vasoconstrictor response to physiological levels of infused aldosterone and that the antioxidant NAC diminishes this response.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa867","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T12:56:46Z","timestamp":1606568206000},"page":"e1262-e1270","source":"Crossref","is-referenced-by-count":4,"title":["Aldosterone Induces Vasoconstriction in Individuals with Type 2 Diabetes: Effect of Acute Antioxidant Administration"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-0697","authenticated-orcid":false,"given":"Stine H\u00f8yer","family":"Finsen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Renal Research, University of Southern Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mie Rytz","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, University of Southern Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-1665","authenticated-orcid":false,"given":"Pernille B L\u00e6rkegaard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, University of Southern Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-1048","authenticated-orcid":false,"given":"Stefan P","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, University of Southern Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"issue":"9","key":"2021122117325319800_CIT0001","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation."},{"issue":"1","key":"2021122117325319800_CIT0002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11154-010-9134-4","article-title":"Endothelial dysfunction in diabetes mellitus: molecular mechanisms and 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