{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:25:37Z","timestamp":1774427137096,"version":"3.50.1"},"reference-count":44,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370327"],"award-info":[{"award-number":["81370327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Metabolic abnormalities have been associated with long-term cardiac mortality in patients with hypertrophic cardiomyopathy (HCM). Obstructive sleep apnea (OSA) is a risk factor for metabolic abnormalities in general populations, but association between OSA and metabolic abnormalities in HCM is still undefined. This study aimed to investigate the relationship between OSA and metabolic dysfunction in a large series of patients with HCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 587 patients with HCM who underwent sleep evaluations at Fuwai Hospital were included. Data from clinical characteristics, polysomnography studies, and metabolic measurements were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>OSA was present in 344 patients (58.6%). Patients with OSA were older, more often male, and had more clinical comorbidities. Body mass index, blood pressure, fasting glucose, and triglycerides all increased (all P\u2005&amp;lt;\u20050.001) and high-density lipoprotein cholesterol decreased (P\u2005=\u20050.046) with the severity of OSA. In multivariate analysis, moderate to severe OSA and Log (apnea-hypopnea index + 1) were independently associated with obesity (odds ratio [OR], 2.42; 95% CI, 1.48-3.95 and OR, 1.60; 95% CI, 1.31-1.95), elevated blood pressure (OR, 1.99; 95% CI, 1.42-3.26 and OR, 1.31; 95% CI, 1.08-1.60), and elevated triglycerides (OR, 1.71; 95% CI, 1.05-2.78 and OR, 1.24; 95% CI, 1.02-1.51 but not elevated fasting glucose (OR, 0.88; 95% CI, 0.50-1.52 and OR, 1.02; 95% CI, 0.82-1.28) or reduced high-density lipoprotein cholesterol (OR, 1.30; 95% CI, 0.83-2.04 and OR, 1.06; 95% CI, 0.89-1.27).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Severity of OSA is independently associated with some profiles of metabolic abnormalities. Clinical trials are required to determine whether OSA treatment improves metabolic abnormalities and long-term outcomes in patients with HCM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab015","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T11:07:30Z","timestamp":1611832050000},"page":"e2309-e2321","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Obstructive Sleep Apnea and Metabolic Abnormalities in Patients With Hypertrophic Cardiomyopathy"],"prefix":"10.1210","volume":"106","author":[{"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haobo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-6486","authenticated-orcid":false,"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"issue":"39","key":"2021122204525789200_CIT0001","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2021122204525789200_CIT0002","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2019.4268","article-title":"Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy","author":"Fumagalli","year":"2020","journal-title":"JAMA Cardiol"},{"issue":"5","key":"2021122204525789200_CIT0003","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jacc.2013.03.062","article-title":"Obesity and its association to phenotype and clinical course in hypertrophic cardiomyopathy","volume":"62","author":"Olivotto","year":"2013","journal-title":"J Am Coll Cardiol."},{"issue":"22","key":"2021122204525789200_CIT0004","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1136\/heartjnl-2016-309843","article-title":"Comparison of hypertrophic cardiomyopathy in Afro-Caribbean versus white patients in the UK","volume":"102","author":"Sheikh","year":"2016","journal-title":"Heart."},{"issue":"9","key":"2021122204525789200_CIT0005","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/01.CIR.92.9.2488","article-title":"Natural history of hypertrophic cardiomyopathy. A population-based study, 1976 through 1990","volume":"92","author":"Cannan","year":"1995","journal-title":"Circulation."},{"issue":"21","key":"2021122204525789200_CIT0006","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/eurheartj\/ehy625","article-title":"The impact of diabetes mellitus on the clinical phenotype of hypertrophic cardiomyopathy","volume":"40","author":"Wasserstrum","year":"2019","journal-title":"Eur Heart J."},{"key":"2021122204525789200_CIT0007","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.smrv.2018.08.009","article-title":"Obstructive sleep apnea and the metabolic syndrome: the road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment","volume":"42","author":"Gaines","year":"2018","journal-title":"Sleep Med Rev."},{"issue":"3","key":"2021122204525789200_CIT0008","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.smrv.2012.06.006","article-title":"Obstructive sleep apnea and hypertrophic cardiomyopathy: a common and potential harmful combination","volume":"17","author":"Nerbass","year":"2013","journal-title":"Sleep Med Rev."},{"issue":"1","key":"2021122204525789200_CIT0009","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1378\/chest.14-0084","article-title":"Sleep-disordered breathing in hypertrophic cardiomyopathy: challenges and opportunities","volume":"146","author":"Konecny","year":"2014","journal-title":"Chest."},{"issue":"8","key":"2021122204525789200_CIT0010","doi-asserted-by":"crossref","first-page":"e015013","DOI":"10.1161\/JAHA.119.015013","article-title":"Implication of apnea-hypopnea index, a measure of obstructive sleep apnea severity, for atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"9","author":"Xu","year":"2020","journal-title":"J Am Heart Assoc."},{"issue":"7","key":"2021122204525789200_CIT0011","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.amjcard.2012.12.018","article-title":"Physical activity and other health behaviors in adults with hypertrophic cardiomyopathy","volume":"111","author":"Reineck","year":"2013","journal-title":"Am J Cardiol."},{"issue":"25","key":"2021122204525789200_CIT0012","doi-asserted-by":"crossref","first-page":"e212","DOI":"10.1016\/j.jacc.2011.06.011","article-title":"2011 ACCF\/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons","volume":"58","author":"Gersh","year":"2011","journal-title":"J Am Coll Cardiol."},{"issue":"5","key":"2021122204525789200_CIT0013","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/sleep\/32.5.629","article-title":"Validation of a portable monitoring system for the diagnosis of obstructive sleep apnea syndrome","volume":"32","author":"Santos-Silva","year":"2009","journal-title":"Sleep."},{"issue":"5","key":"2021122204525789200_CIT0014","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force","volume":"22","year":"1999","journal-title":"Sleep."},{"issue":"3","key":"2021122204525789200_CIT0015","first-page":"370","article-title":"How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: an extension of Asian-Pacific recommendations","volume":"17","author":"Pan","year":"2008","journal-title":"Asia Pac J Clin Nutr."},{"issue":"17","key":"2021122204525789200_CIT0016","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1001\/archinte.158.17.1855","article-title":"Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults","volume":"158","year":"1998","journal-title":"Arch Intern Med"},{"issue":"16","key":"2021122204525789200_CIT0017","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation."},{"issue":"3","key":"2021122204525789200_CIT0018","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1378\/chest.07-0800","article-title":"Obstructive sleep apnea: implications for cardiac and vascular disease","volume":"133","author":"Lopez-Jimenez","year":"2008","journal-title":"Chest."},{"issue":"1","key":"2021122204525789200_CIT0019","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijcard.2009.05.021","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"139","author":"Butt","year":"2010","journal-title":"Int J Cardiol."},{"issue":"9","key":"2021122204525789200_CIT0020","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ehj.2004.02.021","article-title":"Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome","volume":"25","author":"Coughlin","year":"2004","journal-title":"Eur Heart J."},{"key":"2021122204525789200_CIT0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.metabol.2018.03.008","article-title":"Obesity metabolic and hormonal disorders associated with obstructive sleep apnea and their impact on the risk of cardiovascular events","volume":"84","author":"Carneiro","year":"2018","journal-title":"Metabolism."},{"issue":"4","key":"2021122204525789200_CIT0022","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/ajrccm.160.4.9903020","article-title":"Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure","volume":"160","author":"Sin","year":"1999","journal-title":"Am J Respir Crit Care Med."},{"key":"2021122204525789200_CIT0023","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.smrv.2018.07.008","article-title":"Targeting volume overload and overnight rostral fluid shift: a new perspective to treat sleep apnea","volume":"42","author":"Perger","year":"2018","journal-title":"Sleep Med Rev."},{"issue":"12","key":"2021122204525789200_CIT0024","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1164\/rccm.200607-927OC","article-title":"Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects","volume":"174","author":"Chiu","year":"2006","journal-title":"Am J Respir Crit Care Med."},{"key":"2021122204525789200_CIT0025","first-page":"51s","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults--the evidence report. National Institutes of Health","volume":"6 Suppl 2","year":"1998","journal-title":"Obes Res"},{"issue":"5","key":"2021122204525789200_CIT0026","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJMoa020245","article-title":"Obesity and the risk of heart failure","volume":"347","author":"Kenchaiah","year":"2002","journal-title":"N Engl J Med."},{"issue":"7","key":"2021122204525789200_CIT0027","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jacc.2013.05.045","article-title":"Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome","volume":"62","author":"Drager","year":"2013","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"2021122204525789200_CIT0028","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11325-011-0544-7","article-title":"Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome in nonobese adults","volume":"16","author":"Lin","year":"2012","journal-title":"Sleep Breath."},{"issue":"8","key":"2021122204525789200_CIT0029","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/jc.2005-0035","article-title":"Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression","volume":"90","author":"Bixler","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122204525789200_CIT0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.metabol.2018.04.001","article-title":"Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome","volume":"84","author":"Koren","year":"2018","journal-title":"Metabolism."},{"issue":"5","key":"2021122204525789200_CIT0031","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MED.0000000000000276","article-title":"Disturbances of sleep and circadian rhythms: novel risk factors for obesity","volume":"23","author":"Broussard","year":"2016","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"3","key":"2021122204525789200_CIT0032","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1371\/journal.pmed.0010062","article-title":"Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index","volume":"1","author":"Taheri","year":"2004","journal-title":"Plos Med."},{"issue":"6","key":"2021122204525789200_CIT0033","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1378\/chest.14-1498","article-title":"Decreased exercise capacity and sleep-disordered breathing in patients with hypertrophic cardiomyopathy","volume":"147","author":"Konecny","year":"2015","journal-title":"Chest."},{"issue":"24","key":"2021122204525789200_CIT0034","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","article-title":"CPAP, weight loss, or both for obstructive sleep apnea","volume":"370","author":"Chirinos","year":"2014","journal-title":"N Engl J Med."},{"issue":"8","key":"2021122204525789200_CIT0035","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0002-8223(97)00220-4","article-title":"Continuous positive airway pressure treatment results in weight less in obese and overweight patients with obstructive sleep apnea","volume":"97","author":"Loube","year":"1997","journal-title":"J Am Diet Assoc."},{"issue":"6","key":"2021122204525789200_CIT0036","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/hr.2016.11","article-title":"Hypertension and obstructive sleep apnea","volume":"39","author":"Cai","year":"2016","journal-title":"Hypertens Res."},{"issue":"2","key":"2021122204525789200_CIT0037","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.00043614","article-title":"Obstructive sleep apnoea treatment and fasting lipids: a comparative effectiveness study","volume":"44","author":"Keenan","year":"2014","journal-title":"Eur Respir J."},{"issue":"5","key":"2021122204525789200_CIT0038","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","article-title":"Obstructive sleep apnea is independently associated with insulin resistance","volume":"165","author":"Ip","year":"2002","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2021122204525789200_CIT0039","doi-asserted-by":"crossref","first-page":"e0227012","DOI":"10.1371\/journal.pone.0227012","article-title":"Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: a nationwide population-based cohort study","volume":"15","author":"Moon","year":"2020","journal-title":"Plos One."},{"issue":"15","key":"2021122204525789200_CIT0040","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1001\/archinte.1997.00440360178019","article-title":"Population-based study of sleep-disordered breathing as a risk factor for hypertension","volume":"157","author":"Young","year":"1997","journal-title":"Arch Intern Med."},{"issue":"5","key":"2021122204525789200_CIT0041","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.06-1807","article-title":"Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome","volume":"131","author":"Kono","year":"2007","journal-title":"Chest."},{"key":"2021122204525789200_CIT0042","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.resp.2016.11.001","article-title":"Sex differences in sleep disordered breathing in adults","volume":"245","author":"Lozo","year":"2017","journal-title":"Respir Physiol Neurobiol."},{"issue":"1","key":"2021122204525789200_CIT0043","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1183\/09031936.00126712","article-title":"Sleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females","volume":"43","author":"Kritikou","year":"2014","journal-title":"Eur Respir J."},{"issue":"12","key":"2021122204525789200_CIT0044","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1164\/rccm.200504-637OC","article-title":"Association of sleep apnea and type II diabetes: a population-based study","volume":"172","author":"Reichmuth","year":"2005","journal-title":"Am J Respir Crit Care Med."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab015\/36525070\/dgab015.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/5\/e2309\/41848735\/dgab015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/5\/e2309\/41848735\/dgab015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T04:56:02Z","timestamp":1640148962000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/5\/e2309\/6073669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,1,9]]},"published-print":{"date-parts":[[2021,4,23]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab015","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,1,9]]}}}