{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:41:28Z","timestamp":1790289688795,"version":"4.1.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NHLBI K8HL150284"],"award-info":[{"award-number":["NHLBI K8HL150284"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Papillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many genetic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to investigate the association of parental consanguinity with PTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-control study of PTC patients compared with healthy controls took place in a tertiary referral hospital. We recruited 200 PTC patients who were managed at the endocrinology outpatient clinics of the Jordan University Hospital, and we recruited 515 healthy controls from a nonclinical setting. We interviewed all participants and collected sociodemographic data. We reviewed the family pedigrees of each participant four generations back and excluded any participant who was related. We established whether the parents of each participant were first cousins, first cousins once removed, second cousins, or unrelated. We then used binary logistic regression to assess the association of parental consanguinity with PTC adjusted for age, sex, smoking status, body mass index, and parental education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recruited 715 participants. The numbers of PTC patients and healthy controls were 200 (28.0%) and 515 (72.0%), respectively. The rate of parental consanguinity was 25.5% in PTC patients and 12.2% in healthy controls. Parental consanguinity was significantly associated with PTC (adjusted odds ratio, 2.60; 95% CI, 1.63-4.17; P\u2005&amp;lt;\u2005.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parental consanguinity is a risk factor for PTC. Our findings should be considered during familial risk assessment and genetic counseling, especially in populations with high rates of consanguinity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab071","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T02:10:49Z","timestamp":1613355049000},"page":"e2769-e2774","source":"Crossref","is-referenced-by-count":1,"title":["Association of Parental Consanguinity With Papillary Thyroid Carcinoma: A Case-Control Study"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-4769","authenticated-orcid":false,"given":"Ayman A","family":"Zayed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-1077","authenticated-orcid":false,"given":"Justin Z","family":"Amarin","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-3601","authenticated-orcid":false,"given":"Abdallah T","family":"Al-Ani","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq L","family":"Altell","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma, King\u2019s College Hospital NHS Foundation Trust , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-2637","authenticated-orcid":false,"given":"Sultan S","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad M","family":"Qirem","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhib M","family":"Fahmawi","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanad M","family":"Elshebli","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khair M","family":"Hamo","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-685X","authenticated-orcid":false,"given":"Louay Y","family":"Zaghlol","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Tierney","sequence":"additional","affiliation":[{"name":"Hunter\u2013New England Health , New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana A","family":"Zayed","sequence":"additional","affiliation":[{"name":"The University of Jordan School of Medicine , Amman,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-4922","authenticated-orcid":false,"given":"Alireza","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts,","place":["USA"]},{"name":"Department of Genetics, Harvard Medical School , Boston, Massachusetts,","place":["USA"]},{"name":"Broad Institute of MIT and Harvard , Cambridge, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"issue":"10","key":"2026041420193652000_CIT0001","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/jc.2005-0935","article-title":"Familial risks for nonmedullary thyroid cancer","volume":"90","author":"Hemminki","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2026041420193652000_CIT0002","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/his.13373","article-title":"Hereditary and familial thyroid 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