{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:00Z","timestamp":1791231240234,"version":"4.1.0"},"reference-count":24,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Radiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign nonfunctioning thyroid nodules (BNTNs)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of both treatments at 12-month follow-up in patients with solid or predominantly solid BNTN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center, 12-month, randomized, superiority, open-label, parallel-group trial conducted in an outpatient clinic. Sixty patients with a solitary BNTN or dominant nodule characterized by pressure symptoms\/cosmetic problems were randomly assigned (1:1 ratio) to receive either a single session of RFA or LA. Twenty-9 patients per group completed the study. The main outcome measures were VRR and proportion of nodules with more than 50% reduction (technical success rate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12 months, VRR was 70.9\u2005\u00b1\u200516.9% and 60.0\u2005\u00b1\u200519.0% in the RFA and LA groups, respectively (P\u2005=\u2005.024). This effect was confirmed in the linear regression model that was adjusted for age, sex, nodule baseline volume, and proportion of cellular components (RFA treatment: \u03b2\u2005=\u2005.390; P\u2005=\u2005.009). No significant between-group difference was observed in the technical success rate at 12 months after treatment. A statistically significant improvement was observed from the baseline to the 12-month follow-up for compression (RFA: 4.6\u2005\u00b1\u20052.6 and 1.3\u2005\u00b1\u20050.8, P\u2005&amp;lt;\u2005.001; and LA: 4.6\u2005\u00b1\u20052.1 and 1.6\u2005\u00b1\u20050.8, respectively, P\u2005&amp;lt;\u2005.001) and cosmetic (RFA: 3.4\u2005\u00b1\u20050.6 and 1.3\u2005\u00b1\u20050.5, P\u2005&amp;lt;\u2005.001; and LA: 3.4\u2005\u00b1\u20050.5 and 1.4\u2005\u00b1\u20050.6, P\u2005&amp;lt;\u2005.001) scores although the between-group differences were not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RFA achieved a significantly larger nodule volume reduction at 12 months; however, the technical success rate was similar in the RFA and LA groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab102","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T20:38:14Z","timestamp":1613767094000},"page":"1692-1701","source":"Crossref","is-referenced-by-count":43,"title":["Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules: 12-Month Results of a Randomized Trial (LARA II Study)"],"prefix":"10.1210","volume":"106","author":[{"given":"Roberto","family":"Cesareo","sequence":"first","affiliation":[{"name":"Unit of metabolic diseases, \u201cS. M. Goretti\u201d Hospital, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u201cS. M. Goretti\u201d Hospital, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Ambrogi","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u201cS. M. Goretti\u201d Hospital, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sanson","sequence":"additional","affiliation":[{"name":"Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-636X","authenticated-orcid":false,"given":"Paolo","family":"Pozzilli","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pedone","sequence":"additional","affiliation":[{"name":"Geriatric Unit, Campus Bio-Medico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Unit of Pathology, University Hospital Campus Bio-Medico, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-4926","authenticated-orcid":false,"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"issue":"4","key":"2021122205115323200_CIT0001","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000508484","article-title":"2020 European thyroid association clinical practice guideline for the use of image-guided ablation in benign thyroid nodules","volume":"9","author":"Papini","year":"2020","journal-title":"Eur Thyroid J."},{"issue":"1","key":"2021122205115323200_CIT0002","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/02656736.2019.1575482","article-title":"Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group","volume":"36","author":"Papini","year":"2019","journal-title":"Int J Hyperthermia."},{"issue":"6","key":"2021122205115323200_CIT0003","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/cen.13422","article-title":"Radiofrequency ablation for the management of thyroid nodules: a critical appraisal of the literature","volume":"87","author":"Cesareo","year":"2017","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2021122205115323200_CIT0004","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fendo.2020.00317","article-title":"Radiofrequency ablation on autonomously functioning thyroid nodules: a critical appraisal and review of the literature","volume":"11","author":"Cesareo","year":"2020","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"8","key":"2021122205115323200_CIT0005","first-page":"911","article-title":"A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis","volume":"33","author":"Pacella","year":"2017","journal-title":"Int J Hyperthermia."},{"key":"2021122205115323200_CIT0006","article-title":"Five-year results of radiofrequency and laser ablation of benign thyroid nodules: a multicenter study from the Italian minimally invasive treatments of the thyroid group","author":"Bernardi","journal-title":"Thyroid."},{"key":"2021122205115323200_CIT0007","article-title":"Efficacy of thermal ablation in benign non-functioning solid thyroid nodule: a systematic review and meta-analysis","author":"Trimboli","journal-title":"Endocrine"},{"issue":"1","key":"2021122205115323200_CIT0008","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11154-019-09487-y","article-title":"Efficacy of radiofrequency ablation in autonomous functioning thyroid nodules. 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