{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:22:52Z","timestamp":1781356972173,"version":"3.54.1"},"reference-count":64,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The early events regulating the remodeling program following skeletal muscle damage are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to determine the association between myofibrillar protein synthesis (myoPS) and nuclear factor-kappa B (NF-\u03baB) signaling by nutritionally accelerating the recovery of muscle function following damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting, Participants, and Interventions<\/jats:title><jats:p>Healthy males and females consumed daily postexercise and prebed protein-polyphenol (PP; n = 9; 4 females) or isocaloric maltodextrin placebo (PLA; n = 9; 3 females) drinks (parallel design) 6 days before and 3 days after 300 unilateral eccentric contractions of the quadriceps during complete dietary control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Muscle function was assessed daily, and skeletal muscle biopsies were taken after 24, 27, and 36 hours for measurements of myoPS rates using deuterated water, and gene ontology and NF-\u03baB signaling analysis using a quantitative reverse transcription PCR (RT-qPCR) gene array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eccentric contractions impaired muscle function for 48 hours in PLA intervention, but just for 24 hours in PP intervention (P = 0.047). Eccentric quadricep contractions increased myoPS compared with the control leg during postexercise (24\u201327 hours; 0.14 \u00b1 0.01 vs 0.11 \u00b1 0.01%\u00b7h-1, respectively; P = 0.075) and overnight periods (27\u201336 hours; 0.10 \u00b1 0.01 vs 0.07 \u00b1 0.01%\u00b7h-1, respectively; P = 0.020), but was not further increased by PP drinks (P &amp;gt; 0.05). Protein-polyphenol drinks decreased postexercise and overnight muscle IL1R1 (PLA = 2.8 \u00b1 0.4, PP = 1.1 \u00b1 0.4 and PLA = 1.9 \u00b1 0.4, PP = 0.3 \u00b1 0.4 log2 fold-change, respectively) and IL1RL1 (PLA = 4.9 \u00b1 0.7, PP = 1.6 \u00b1 0.8 and PLA = 3.7 \u00b1 0.6, PP = 0.7 \u00b1 0.7 log2 fold-change, respectively) messenger RNA expression (P &amp;lt; 0.05) and downstream NF-\u03baB signaling compared with PLA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Protein-polyphenol drink ingestion likely accelerates recovery of muscle function by attenuating inflammatory NF-\u03baB transcriptional signaling, possibly to reduce aberrant tissue degradation rather than increase myoPS rates.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgab106","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T14:41:16Z","timestamp":1615560076000},"page":"2057-2076","source":"Crossref","is-referenced-by-count":23,"title":["Reducing NF-\u03baB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-0862","authenticated-orcid":false,"given":"Tom S O","family":"Jameson","sequence":"first","affiliation":[{"name":"Nutritional Physiology Group, Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX1 2LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F","family":"Pavis","sequence":"additional","affiliation":[{"name":"Nutritional Physiology Group, Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX1 2LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-1042","authenticated-orcid":false,"given":"Marlou 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Alamdari","sequence":"additional","affiliation":[{"name":"Beachbody LLC, Santa Monica, CA 90404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine R","family":"Mikus","sequence":"additional","affiliation":[{"name":"Beachbody LLC, Santa Monica, CA 90404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T","family":"Wall","sequence":"additional","affiliation":[{"name":"Nutritional Physiology Group, Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX1 2LU, 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