{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:46:28Z","timestamp":1791571588661,"version":"4.3.4"},"reference-count":72,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MRC Clinical Research Training Fellowship","award":["MR\/T006242\/1"],"award-info":[{"award-number":["MR\/T006242\/1"]}]},{"name":"NIHR) Research Professorship","award":["NIHR-RP-2014-05-001"],"award-info":[{"award-number":["NIHR-RP-2014-05-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The ideal therapy for endometriosis (EM) and uterine fibroids (UFs) would suppress estrogenic drive to the endometrium and myometrium, while minimizing vasomotor symptoms and bone loss associated with current treatments. An integrated neurokinin-kisspeptin system involving substance P and neurokinin B acting at the neurokinin (NK) receptors 1 and 3, respectively, modulates reproductive hormone secretion and represents a therapeutic target.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to assess the effects of the novel NK1,3 antagonist elinzanetant on reproductive hormone levels in healthy women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A randomized, single-blinded, placebo-controlled study was conducted in 33 women who attended for 2 consecutive menstrual cycles. In each cycle blood samples were taken on days 3 or 4, 9 or 10, 15 or 16, and 21 or 22 to measure serum reproductive hormones. In cycle 2, women were randomly assigned to receive once-daily oral elinzanetant 40, 80, 120 mg, or placebo (N\u2005=\u20058 or 9 per group).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Elinzanetant dose-dependently lowered serum luteinizing hormone, estradiol (120 mg median change across cycle: \u2013141.4 pmol\/L, P\u2005=\u2005.038), and luteal-phase progesterone (120 mg change from baseline on day 21 or 22: \u201319.400 nmol\/L, P\u2005=\u2005.046). Elinzanetant 120 mg prolonged the cycle length by median of 7.0 days (P\u2005=\u2005.023). Elinzanetant reduced the proportion of women with a luteal-phase serum progesterone concentration greater than 30 nmol\/L (a concentration consistent with ovulation) in a dose-related manner in cycle 2 (P\u2005=\u2005.002). Treatment did not produce vasomotor symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>NK1,3 receptor antagonism with elinzanetant dose-dependently suppressed the reproductive axis in healthy women, with the 120-mg dose lowering estradiol to potentially ideal levels for UFs and EM. As such, elinzanetant may represent a novel therapy to manipulate reproductive hormone levels in women with hormone-driven disorders.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab108","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T11:21:28Z","timestamp":1614165688000},"page":"e3221-e3234","source":"Crossref","is-referenced-by-count":33,"title":["Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women"],"prefix":"10.1210","volume":"106","author":[{"given":"Steve","family":"Pawsey","sequence":"first","affiliation":[{"name":"NeRRe Therapeutics Limited, Stevenage, SG1 2FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard Gregory","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 ONN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"NeRRe Therapeutics Limited, Stevenage, SG1 2FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsteen","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Jade Consultants (Cambridge) Limited, CB24 8RX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Kerr","sequence":"additional","affiliation":[{"name":"NeRRe Therapeutics Limited, Stevenage, SG1 2FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Trower","sequence":"additional","affiliation":[{"name":"NeRRe Therapeutics Limited, Stevenage, SG1 2FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-4316","authenticated-orcid":false,"given":"Waljit Singh","family":"Dhillo","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 ONN, UK"},{"name":"Imperial Consultants, Imperial College London, London, SW7 2PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"issue":"10","key":"2021071319420728400_CIT0001","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG."},{"issue":"13","key":"2021071319420728400_CIT0002","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J 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