{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:42:35Z","timestamp":1791214955567,"version":"4.1.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Pharmacological lowering of low-density lipoprotein (LDL) cholesterol potently reduces cardiovascular risk while concurrently increasing type 2 diabetes risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the relationship between LDL cholesterol concentrations and insulin secretion and glucagon levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 3039 individuals without cholesterol-lowering therapy, but with increased risk for diabetes, underwent routine blood tests and a 5-point oral glucose tolerance test (OGTT). Glucagon concentrations, insulin secretion, and insulin clearance indices were derived from the OGTT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was no association between LDL cholesterol and fasting glucagon (P\u2005=\u2005.7, \u03b2\u2005=\u2005\u2013.01) or post\u2013glucose load glucagon levels (P\u2005=\u2005.7, \u03b2\u2005=\u2005\u2013.07), but we detected significant positive associations of LDL cholesterol and C-peptide\u2013based indices of insulin secretion (area under the curve [AUC]C-Peptide(0-30min)\/AUCGlucose(0-30min): P\u2005&amp;lt;\u2005.001, \u03b2\u2005=\u2005.06; AUCC-Peptide(0-120min) \/AUCGlucose(0-120min): P\u2005&amp;lt;\u2005.001, \u03b2\u2005=\u2005\u2013.08). In contrast, we found a negative association of insulin-based insulin secretion indices with LDL concentrations (insulinogenic index: P\u2005=\u2005.01, \u03b2\u2005=\u2005\u2013.04; disposition index: P\u2005&amp;lt; .001, \u03b2\u2005=\u2005\u2013.06). LDL cholesterol levels, however, were positively associated with insulin clearance assessed from C-peptide and insulin concentrations, both in the fasting state and post\u2013glucose load (P\u2005&amp;lt;\u2005.001, \u03b2\u2005=\u2005.09 and P\u2005&amp;lt;\u2005.001, \u03b2\u2005=\u2005.06, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>As C-peptide based indices reflect insulin secretion independent of hepatic clearance, our results indicate lower insulin secretion in case of lesser LDL cholesterol. This could explain deteriorating glycemic control in response to cholesterol-lowering drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab147","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:37:41Z","timestamp":1615462661000},"page":"1576-1584","source":"Crossref","is-referenced-by-count":28,"title":["Low-Density Lipoprotein Cholesterol Is Associated With Insulin Secretion"],"prefix":"10.1210","volume":"106","author":[{"given":"Corinna","family":"Dannecker","sequence":"first","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hummel","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Vosseler","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, 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