{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:22:44Z","timestamp":1780082564477,"version":"3.54.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique","award":["HE 3557\/1-1"],"award-info":[{"award-number":["HE 3557\/1-1"]}]},{"name":"SICPA Foundation","award":["HE 3557\/1-1"],"award-info":[{"award-number":["HE 3557\/1-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Men with congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) have both low circulating testosterone and estradiol levels. Whether bone structure is affected remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To characterize bone geometry, volumetric density and microarchitecture in CHH\/KS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study, conducted at a single French tertiary academic medical center, included 51 genotyped CHH\/KS patients and 40 healthy volunteers. Among CHH\/KS men, 98% had received testosterone and\/or combined gonadotropins. High-resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy x-ray absorptiometry (DXA), and measurement of serum bone markers were used to determine volumetric bone mineral density (vBMD) and cortical and trabecular microarchitecture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CHH and controls did not differ for age, body mass index, and levels of vitamin D and PTH. Despite long-term hormonal treatment (10.8 \u00b1 6.8 years), DXA showed lower areal bone mineral density (aBMD) in CHH\/KS at lumbar spine, total hip, femoral neck, and distal radius. Consistent with persistently higher serum bone markers, HR-pQCT revealed lower cortical and trabecular vBMD as well as cortical thickness at the tibia and the radius. CHH\/KS men had altered trabecular microarchitecture with a predominant decrease of trabecular thickness. Moreover, CHH\/KS men exhibited lower cortical bone area, whereas total and trabecular areas were higher only at the tibia. Earlier treatment onset (before age 19 years) conferred a significant advantage for trabecular bone volume\/tissue volume and trabecular vBMD at the tibia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Both vBMD and bone microarchitecture remain impaired in CHH\/KS men despite long-term hormonal treatment. Treatment initiation during adolescence is associated with enhanced trabecular outcomes, highlighting the importance of early diagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab169","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T22:38:25Z","timestamp":1615934305000},"page":"e3312-e3326","source":"Crossref","is-referenced-by-count":23,"title":["Compromised Volumetric Bone Density and Microarchitecture in Men With Congenital Hypogonadotropic Hypogonadism"],"prefix":"10.1210","volume":"106","author":[{"given":"Agn\u00e8s","family":"Ostertag","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Universit\u00e9 de Paris and INSERM UMR-U1132 (Biology of bone and cartilage research unit), H\u00f4pital Lariboisi\u00e8re, F-75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0099-6755","authenticated-orcid":false,"given":"Georgios 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