{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:54:51Z","timestamp":1793332491332,"version":"4.5.0"},"reference-count":111,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100003135","name":"Minnesota Ovarian Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA229697"],"award-info":[{"award-number":["R01CA229697"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA188571"],"award-info":[{"award-number":["R01CA188571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA228991"],"award-info":[{"award-number":["P50 CA228991"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001036","name":"Claneil Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent studies indicate no effect or enhanced OC risk. Knowledge of progesterone receptor (PR) signaling during altered physiology that typifies OC development is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study defines PR-driven oncogenic signaling mechanisms in p53-mutant human fallopian tube epithelia (hFTE), a precursor of the most aggressive OC subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PR expression in clinical samples of serous tubal intraepithelial carcinoma (STIC) lesions and high-grade serous OC (HGSC) tumors was analyzed. Novel PR-A and PR-B isoform-expressing hFTE models were characterized for gene expression and cell cycle progression, emboli formation, and invasion. PR regulation of the DREAM quiescence complex and DYRK1 kinases was established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>STICs and HGSC express abundant activated phospho-PR. Progestin promoted reversible hFTE cell cycle arrest, spheroid formation, and invasion. RNAseq\/biochemical studies revealed potent ligand-independent\/-dependent PR actions, progestin-induced regulation of the DREAM quiescence complex, and cell cycle target genes through enhanced complex formation and chromatin recruitment. Disruption of DREAM\/DYRK1s by pharmacological inhibition, HPV E6\/E7 expression, or DYRK1A\/B depletion blocked progestin-induced cell arrest and attenuated PR-driven gene expression and associated OC phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Activated PRs support quiescence and pro-survival\/pro-dissemination cell behaviors that may contribute to early HGSC progression. Our data support an alternative perspective on the tenet that progesterone always confers protection against OC. STICs can reside undetected for decades prior to invasive disease; our studies reveal clinical opportunities to prevent the ultimate development of HGSC by targeting PRs, DREAM, and\/or DYRKs.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgab195","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:37:27Z","timestamp":1616531847000},"page":"1929-1955","source":"Crossref","is-referenced-by-count":28,"title":["Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-8299","authenticated-orcid":false,"given":"Laura J","family":"Mauro","sequence":"first","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"},{"name":"University of Minnesota, Department of Animal Science, St. Paul, MN 55108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan I","family":"Seibel","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H","family":"Diep","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Spartz","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Perez Kerkvliet","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Singhal","sequence":"additional","affiliation":[{"name":"Northwestern University, Department of Surgery, Feinberg School of Medicine, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M","family":"Swisher","sequence":"additional","affiliation":[{"name":"University of Washington Seattle, Dept Obstetrics & Gynecology, Division of Gynecologic Oncology, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E","family":"Schwartz","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Dept of Pathology and Laboratory Medicine, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Penn Ovarian Cancer Research Center, Dept Obstetrics & Gynecology, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Saini","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Massey Cancer Center, Dept. Internal Medicine, Division of Hematology, Oncology & Palliative Care, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatmata","family":"Sesay","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Massey Cancer Center, Dept. Internal Medicine, Division of Hematology, Oncology & Palliative Care, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Litovchick","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Massey Cancer Center, Dept. Internal Medicine, Division of Hematology, Oncology & Palliative Care, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-3976","authenticated-orcid":false,"given":"Carol A","family":"Lange","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA"},{"name":"University of Minnesota, Dept Medicine, Division of Hematology, Oncology & Transplantation, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"issue":"13","key":"2021122203532416500_CIT0001","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/cncr.31551","article-title":"Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics","volume":"124","author":"Cronin","year":"2018","journal-title":"Cancer."},{"issue":"1","key":"2021122203532416500_CIT0002","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer: a review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol Med."},{"issue":"11","key":"2021122203532416500_CIT0003","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/bjc.2015.377","article-title":"Reproductive factors and epithelial ovarian cancer survival in the EPIC cohort study","volume":"113","author":"Be\u0161evi\u0107","year":"2015","journal-title":"Br J Cancer."},{"key":"2021122203532416500_CIT0004","doi-asserted-by":"crossref","first-page":"k3609","DOI":"10.1136\/bmj.k3609","article-title":"Association between contemporary hormonal contraception and ovarian cancer in women of reproductive age in Denmark: prospective, nationwide cohort study","volume":"362","author":"Iversen","year":"2018","journal-title":"Bmj."},{"issue":"24","key":"2021122203532416500_CIT0005","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1200\/JCO.2016.66.8178","article-title":"Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium","volume":"34","author":"Wentzensen","year":"2016","journal-title":"J Clin Oncol."},{"issue":"9980","key":"2021122203532416500_CIT0006","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0140-6736(14)61687-1","article-title":"Menopausal hormone use and ovarian cancer risk: Individual participant meta-analysis of 52 epidemiological studies","volume":"385","author":"Collaborative Group On Epidemiological Studies Of Ovarian C","year":"2015","journal-title":"Lancet"},{"issue":"9574","key":"2021122203532416500_CIT0007","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0140-6736(07)60534-0","article-title":"Ovarian cancer and hormone replacement therapy in the Million Women Study","volume":"369","author":"Beral","year":"2007","journal-title":"Lancet."},{"issue":"9","key":"2021122203532416500_CIT0008","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.4161\/cc.24550","article-title":"Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells","volume":"12","author":"Diep","year":"2013","journal-title":"Cell Cycle."},{"issue":"2","key":"2021122203532416500_CIT0009","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1158\/1541-7786.MCR-15-0431","article-title":"Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming","volume":"14","author":"Diep","year":"2016","journal-title":"Mol Cancer Res."},{"issue":"3","key":"2021122203532416500_CIT0010","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ygyno.2009.08.023","article-title":"Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma","volume":"115","author":"Liu","year":"2009","journal-title":"Gynecol Oncol."},{"issue":"1","key":"2021122203532416500_CIT0011","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"J Pathol."},{"issue":"1","key":"2021122203532416500_CIT0012","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Labidi-Galy","year":"2017","journal-title":"Nat Commun."},{"issue":"1","key":"2021122203532416500_CIT0013","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41467-017-01217-9","article-title":"Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma","volume":"8","author":"Ducie","year":"2017","journal-title":"Nat Commun."},{"issue":"1","key":"2021122203532416500_CIT0014","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.5219","article-title":"Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions","volume":"248","author":"Wu","year":"2019","journal-title":"J Pathol."},{"issue":"2","key":"2021122203532416500_CIT0015","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1530\/JME-14-0252","article-title":"Progesterone action in breast, uterine, and ovarian cancers","volume":"54","author":"Diep","year":"2015","journal-title":"J Mol Endocrinol."},{"key":"2021122203532416500_CIT0016","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3233\/BD-2003-18104","article-title":"Cross-talk between growth factor and progesterone receptor signaling pathways: implications for breast cancer cell growth","volume":"18","author":"Pierson-Mullany","year":"2003","journal-title":"Breast Dis."},{"issue":"34","key":"2021122203532416500_CIT0017","doi-asserted-by":"crossref","first-page":"14287","DOI":"10.1073\/pnas.0905118106","article-title":"Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells","volume":"106","author":"Daniel","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021122203532416500_CIT0018","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1186\/bcr3211","article-title":"Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression","volume":"14","author":"Knutson","year":"2012","journal-title":"Breast Cancer Res."},{"issue":"1","key":"2021122203532416500_CIT0019","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13045-017-0462-7","article-title":"Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs","volume":"10","author":"Knutson","year":"2017","journal-title":"J Hematol Oncol."},{"issue":"1-2","key":"2021122203532416500_CIT0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mce.2009.01.004","article-title":"Signaling inputs to progesterone receptor gene regulation and promoter selectivity","volume":"308","author":"Daniel","year":"2009","journal-title":"Mol Cell Endocrinol."},{"issue":"4","key":"2021122203532416500_CIT0021","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/onc.2013.579","article-title":"Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes","volume":"34","author":"Daniel","year":"2015","journal-title":"Oncogene."},{"issue":"4","key":"2021122203532416500_CIT0022","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.molcel.2006.01.014","article-title":"Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression","volume":"21","author":"Cvoro","year":"2006","journal-title":"Mol Cell."},{"issue":"7","key":"2021122203532416500_CIT0023","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.steroids.2008.12.001","article-title":"Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation","volume":"74","author":"Dressing","year":"2009","journal-title":"Steroids."},{"issue":"1","key":"2021122203532416500_CIT0024","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-16-0302","article-title":"Oviduct: roles in fertilization and early embryo development","volume":"232","author":"Li","year":"2017","journal-title":"J Endocrinol."},{"issue":"2","key":"2021122203532416500_CIT0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2014.12.015","article-title":"Three-dimensional modeling of the human fallopian tube fimbriae","volume":"136","author":"Eddie","year":"2015","journal-title":"Gynecol Oncol."},{"key":"2021122203532416500_CIT0026","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2121-14-43","article-title":"In vitro three-dimensional modeling of fallopian tube secretory epithelial cells","volume":"14","author":"Lawrenson","year":"2013","journal-title":"BMC Cell Biol."},{"key":"2021122203532416500_CIT0027","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fonc.2018.00223","article-title":"MuvB: A Key to Cell Cycle Control in Ovarian Cancer","volume":"8","author":"Iness","year":"2018","journal-title":"Front Oncol."},{"issue":"9","key":"2021122203532416500_CIT0028","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrc3793","article-title":"Mechanisms of disseminated cancer cell dormancy: an awakening field","volume":"14","author":"Sosa","year":"2014","journal-title":"Nat Rev Cancer."},{"issue":"2","key":"2021122203532416500_CIT0029","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tips.2018.12.004","article-title":"Targeting Cancer Cell Dormancy","volume":"40","author":"Recasens","year":"2019","journal-title":"Trends Pharmacol Sci."},{"issue":"2","key":"2021122203532416500_CIT0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ijc.25692","article-title":"Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk\/dyrk1b and p130\/RB2","volume":"129","author":"Hu","year":"2011","journal-title":"Int J Cancer."},{"issue":"7","key":"2021122203532416500_CIT0031","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/s41388-018-0490-y","article-title":"The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb","volume":"38","author":"Iness","year":"2019","journal-title":"Oncogene."},{"key":"2021122203532416500_CIT0032","article-title":"Data from: Progesterone receptors promote quiescence and ovarian cancer cell phenotypes via regulation of dream in p53-mutant fallopian tube models","author":"Mauro","year":"2021"},{"issue":"9","key":"2021122203532416500_CIT0033","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/modpathol.2011.85","article-title":"Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis","volume":"24","author":"Yemelyanova","year":"2011","journal-title":"Mod Pathol."},{"issue":"6","key":"2021122203532416500_CIT0034","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11060884","article-title":"Loss of PTEN in fallopian tube epithelium results in multicellular tumor spheroid formation and metastasis to the ovary","volume":"11","author":"Dean","year":"2019","journal-title":"Cancers (Basel)."},{"issue":"4","key":"2021122203532416500_CIT0035","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1128\/jvi.66.4.2125-2134.1992","article-title":"The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells","volume":"66","author":"Halbert","year":"1992","journal-title":"J Virol."},{"issue":"1","key":"2021122203532416500_CIT0036","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics."},{"issue":"3","key":"2021122203532416500_CIT0037","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat Protoc."},{"issue":"12","key":"2021122203532416500_CIT0038","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for rna-seq data with deseq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"43","key":"2021122203532416500_CIT0039","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"2021122203532416500_CIT0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1158\/1078-0432.CCR-19-0443","article-title":"Selective Progesterone Receptor Modulators in Early-Stage Breast Cancer: A Randomized, Placebo-Controlled Phase II Window-of-Opportunity Trial Using Telapristone Acetate","volume":"26","author":"Lee","year":"2020","journal-title":"Clin Cancer Res."},{"key":"2021122203532416500_CIT0041","article-title":"Data from: Progesterone receptors promote quiescence and ovarian cancer cell phenotypes via regulation of dream in p53-mutant fallopian tube models. Gene expression Omnibus (GEO) database","author":"Mauro","year":"2020; 31, 2021"},{"key":"2021122203532416500_CIT0042","doi-asserted-by":"crossref","first-page":"28.6.1","DOI":"10.1002\/0471142727.mb2806s111","article-title":"Assaying Cell Cycle Status Using Flow Cytometry","volume":"111","author":"Kim","year":"2015","journal-title":"Curr Protoc Mol Biol."},{"issue":"1","key":"2021122203532416500_CIT0043","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1210\/me.2006-0041","article-title":"Focal subnuclear distribution of progesterone receptor is ligand dependent and associated with transcriptional activity","volume":"21","author":"Arnett-Mansfield","year":"2007","journal-title":"Mol Endocrinol."},{"issue":"3","key":"2021122203532416500_CIT0044","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ygyno.2015.06.037","article-title":"Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus","volume":"138","author":"Bonneterre","year":"2015","journal-title":"Gynecol Oncol."},{"issue":"12","key":"2021122203532416500_CIT0045","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1210\/me.2007-0248","article-title":"Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells","volume":"21","author":"Daniel","year":"2007","journal-title":"Mol Endocrinol."},{"issue":"3","key":"2021122203532416500_CIT0046","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1073\/pnas.97.3.1032","article-title":"Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome","volume":"97","author":"Lange","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2021122203532416500_CIT0047","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/0008-5472.CAN-13-2247","article-title":"Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers","volume":"74","author":"Karst","year":"2014","journal-title":"Cancer Res."},{"issue":"10","key":"2021122203532416500_CIT0048","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86829","article-title":"Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition","volume":"1","author":"Iwanicki","year":"2016","journal-title":"JCI Insight"},{"issue":"1","key":"2021122203532416500_CIT0049","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2008.11.032","article-title":"Multicellular spheroids in ovarian cancer metastases: Biology and pathology","volume":"113","author":"Shield","year":"2009","journal-title":"Gynecol Oncol."},{"key":"2021122203532416500_CIT0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1479-5876-4-6","article-title":"Disaggregation and invasion of ovarian carcinoma ascites spheroids","volume":"4","author":"Burleson","year":"2006","journal-title":"J Transl Med."},{"issue":"10","key":"2021122203532416500_CIT0051","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1073\/pnas.90.10.4441","article-title":"The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways","volume":"90","author":"Beck","year":"1993","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"2021122203532416500_CIT0052","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/er.2003-0023","article-title":"Coregulator function: a key to understanding tissue specificity of selective receptor modulators","volume":"25","author":"Smith","year":"2004","journal-title":"Endocr Rev."},{"issue":"12","key":"2021122203532416500_CIT0053","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1210\/en.2011-1470","article-title":"Minireview: Recent advances in extranuclear steroid receptor actions","volume":"152","author":"Hammes","year":"2011","journal-title":"Endocrinology."},{"issue":"2","key":"2021122203532416500_CIT0054","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yfrne.2008.01.001","article-title":"Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions","volume":"29","author":"Thomas","year":"2008","journal-title":"Front Neuroendocrinol."},{"issue":"2","key":"2021122203532416500_CIT0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Cancer Discov."},{"issue":"2","key":"2021122203532416500_CIT0056","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1158\/2159-8290.CD-11-0117","article-title":"The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer","volume":"1","author":"Kenny","year":"2011","journal-title":"Cancer Discov."},{"key":"2021122203532416500_CIT0057","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-3163-6-11","article-title":"Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis","volume":"6","author":"Shield","year":"2007","journal-title":"J Carcinog."},{"issue":"3","key":"2021122203532416500_CIT0058","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/B:JOMG.0000010028.48159.84","article-title":"Expression profiling of human breast cancers and gene regulation by progesterone receptors","volume":"8","author":"Jacobsen","year":"2003","journal-title":"J Mammary Gland Biol Neoplasia."},{"issue":"6","key":"2021122203532416500_CIT0059","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-04-3924","article-title":"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas","volume":"65","author":"Drapkin","year":"2005","journal-title":"Cancer Res."},{"issue":"6","key":"2021122203532416500_CIT0060","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/humrep\/dey083","article-title":"Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?","volume":"33","author":"Tempest","year":"2018","journal-title":"Hum Reprod."},{"issue":"13","key":"2021122203532416500_CIT0061","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.7150\/jca.30588","article-title":"Estradiol and Progesterone Induced Differentiation and Increased Stemness Gene Expression of Human Fallopian Tube Epithelial Cells","volume":"10","author":"Chang","year":"2019","journal-title":"J Cancer."},{"issue":"2","key":"2021122203532416500_CIT0062","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbrc.2003.08.151","article-title":"Differential regulation of secretory leukocyte protease inhibitor and elafin by progesterone","volume":"310","author":"King","year":"2003","journal-title":"Biochem Biophys Res Commun."},{"issue":"13","key":"2021122203532416500_CIT0063","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1093\/nar\/gkw523","article-title":"Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks","volume":"44","author":"Fischer","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"31","key":"2021122203532416500_CIT0064","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1038\/onc.2013.449","article-title":"Human papillomavirus type 16 E7 perturbs DREAM to promote cellular proliferation and mitotic gene expression","volume":"33","author":"DeCaprio","year":"2014","journal-title":"Oncogene."},{"issue":"1","key":"2021122203532416500_CIT0065","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1038\/s41598-017-02831-9","article-title":"Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway","volume":"7","author":"Fischer","year":"2017","journal-title":"Sci Rep."},{"issue":"7","key":"2021122203532416500_CIT0066","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/febs.14347","article-title":"A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy","volume":"285","author":"Becker","year":"2018","journal-title":"Febs J."},{"issue":"4","key":"2021122203532416500_CIT0067","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/CCO.0000000000000090","article-title":"The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors","volume":"26","author":"DeCaprio","year":"2014","journal-title":"Curr Opin Oncol."},{"issue":"12","key":"2021122203532416500_CIT0068","doi-asserted-by":"crossref","first-page":"R488","DOI":"10.1016\/j.cub.2015.02.067","article-title":"DYRK protein kinases","volume":"25","author":"Soppa","year":"2015","journal-title":"Curr Biol."},{"issue":"8","key":"2021122203532416500_CIT0069","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1101\/gad.2034211","article-title":"DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly","volume":"25","author":"Litovchick","year":"2011","journal-title":"Genes Dev."},{"issue":"8","key":"2021122203532416500_CIT0070","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/1947601910377644","article-title":"Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells","volume":"1","author":"Hu","year":"2010","journal-title":"Genes Cancer."},{"key":"2021122203532416500_CIT0071","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ncomms1090","article-title":"Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A","volume":"1","author":"Ogawa","year":"2010","journal-title":"Nat Commun."},{"issue":"4","key":"2021122203532416500_CIT0072","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1158\/1541-7786.MCR-16-0323-T","article-title":"A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy","volume":"15","author":"MacDonald","year":"2017","journal-title":"Mol Cancer Res."},{"issue":"10","key":"2021122203532416500_CIT0073","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1210\/en.2015-1392","article-title":"Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis","volume":"156","author":"Brisken","year":"2015","journal-title":"Endocrinology."},{"issue":"2","key":"2021122203532416500_CIT0074","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1210\/me.2004-0306","article-title":"Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases","volume":"19","author":"Skildum","year":"2005","journal-title":"Mol Endocrinol."},{"issue":"2","key":"2021122203532416500_CIT0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.steroids.2006.11.009","article-title":"Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth","volume":"72","author":"Daniel","year":"2007","journal-title":"Steroids."},{"issue":"4","key":"2021122203532416500_CIT0076","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1210\/me.2013-1196","article-title":"Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells","volume":"28","author":"Dressing","year":"2014","journal-title":"Mol Endocrinol."},{"issue":"2","key":"2021122203532416500_CIT0077","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1128\/MCB.01539-06","article-title":"Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1\/2 mitogen-activated protein kinase in breast cancer cells","volume":"27","author":"Faivre","year":"2007","journal-title":"Mol Cell Biol."},{"issue":"652","key":"2021122203532416500_CIT0078","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaz9646","article-title":"Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms","volume":"13","author":"Wetendorf","year":"2020","journal-title":"Sci Signal"},{"issue":"49","key":"2021122203532416500_CIT0079","doi-asserted-by":"crossref","first-page":"38221","DOI":"10.1074\/jbc.M004424200","article-title":"A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence","volume":"275","author":"Carroll","year":"2000","journal-title":"J Biol Chem."},{"issue":"3","key":"2021122203532416500_CIT0080","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/MCB.19.3.2251","article-title":"Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice","volume":"19","author":"Tong","year":"1999","journal-title":"Mol Cell Biol."},{"issue":"4","key":"2021122203532416500_CIT0081","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1128\/MCB.18.4.1812","article-title":"Mechanisms of cyclin-dependent kinase inactivation by progestins","volume":"18","author":"Musgrove","year":"1998","journal-title":"Mol Cell Biol."},{"issue":"2","key":"2021122203532416500_CIT0082","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/JOE-11-0310","article-title":"Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1","volume":"214","author":"Diaz","year":"2012","journal-title":"J Endocrinol."},{"issue":"9","key":"2021122203532416500_CIT0083","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1091\/mbc.e12-11-0807","article-title":"Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes","volume":"24","author":"Bellance","year":"2013","journal-title":"Mol Biol Cell."},{"issue":"2","key":"2021122203532416500_CIT0084","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1677\/ERC-09-0258","article-title":"Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase","volume":"17","author":"Fu","year":"2010","journal-title":"Endocr Relat Cancer."},{"key":"2021122203532416500_CIT0085","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ebiom.2019.08.035","article-title":"Molecular mechanisms underlying mifepristone\u2019s agonistic action on ovarian cancer progression","volume":"47","author":"Ponikwicka-Tyszko","year":"2019","journal-title":"Ebiomedicine."},{"key":"2021122203532416500_CIT0086","doi-asserted-by":"crossref","first-page":"105492","DOI":"10.1016\/j.jsbmb.2019.105492","article-title":"Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines","volume":"196","author":"Pelegrina","year":"2020","journal-title":"J Steroid Biochem Mol Biol."},{"key":"2021122203532416500_CIT0087","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jsbmb.2018.08.011","article-title":"Progesterone up-regulates p27 through an increased binding of the progesterone receptor-A-p53 protein complex onto the non-canonical p53 binding motif in HUVEC","volume":"185","author":"Hsu","year":"2019","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"1","key":"2021122203532416500_CIT0088","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1210\/en.2014-1629","article-title":"Progesterone receptor-NF\u03baB complex formation is required for progesterone-induced NF\u03baB nuclear translocation and binding onto the p53 promoter","volume":"156","author":"Hsu","year":"2015","journal-title":"Endocrinology."},{"issue":"7","key":"2021122203532416500_CIT0089","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1158\/1078-0432.CCR-16-0620","article-title":"Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition","volume":"23","author":"Au-Yeung","year":"2017","journal-title":"Clin Cancer Res."},{"issue":"3","key":"2021122203532416500_CIT0090","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/IGC.0b013e318280f3e0","article-title":"The prevalence of human papillomavirus in ovarian cancer: a systematic review","volume":"23","author":"Rosa","year":"2013","journal-title":"Int J Gynecol Cancer."},{"issue":"5-6","key":"2021122203532416500_CIT0091","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000506050","article-title":"Detection of Human Papillomavirus Prevalence in Ovarian Cancer by Different Test Systems","volume":"62","author":"Kisseljova","year":"2019","journal-title":"Intervirology."},{"issue":"5-7","key":"2021122203532416500_CIT0092","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.steroids.2005.02.012","article-title":"Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators","volume":"70","author":"Faivre","year":"2005","journal-title":"Steroids."},{"issue":"6","key":"2021122203532416500_CIT0093","doi-asserted-by":"crossref","first-page":"e1501924","DOI":"10.1126\/sciadv.1501924","article-title":"Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer","volume":"2","author":"Singhal","year":"2016","journal-title":"Sci Adv."},{"issue":"28","key":"2021122203532416500_CIT0094","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1038\/onc.2014.298","article-title":"Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a","volume":"34","author":"Finlay-Schultz","year":"2015","journal-title":"Oncogene."},{"issue":"1-2","key":"2021122203532416500_CIT0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10911-015-9340-5","article-title":"Steroid hormones, steroid receptors, and breast cancer stem cells","volume":"20","author":"Finlay-Schultz","year":"2015","journal-title":"J Mammary Gland Biol Neoplasia."},{"issue":"11","key":"2021122203532416500_CIT0096","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1054\/bjoc.2000.1463","article-title":"Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies","volume":"83","author":"Akahira","year":"2000","journal-title":"Br J Cancer."},{"issue":"7","key":"2021122203532416500_CIT0097","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1349-7006.2002.tb01323.x","article-title":"Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors","volume":"93","author":"Akahira","year":"2002","journal-title":"Jpn J Cancer Res."},{"key":"2021122203532416500_CIT0098","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/1471-2407-12-553","article-title":"Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival","volume":"12","author":"Lenhard","year":"2012","journal-title":"BMC Cancer."},{"issue":"8","key":"2021122203532416500_CIT0099","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/jcp.54.8.624","article-title":"Detection of progesterone receptor forms A and B by immunohistochemical analysis","volume":"54","author":"Mote","year":"2001","journal-title":"J Clin Pathol."},{"issue":"4","key":"2021122203532416500_CIT0100","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cjp2.83","article-title":"Isoform specificity of progesterone receptor antibodies","volume":"3","author":"Fabris","year":"2017","journal-title":"J Pathol Clin Res."},{"issue":"5","key":"2021122203532416500_CIT0101","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/PGP.0000000000000179","article-title":"Immunophenotypic Analysis in Early M\u00fcllerian Serous Carcinogenesis","volume":"34","author":"Nafisi","year":"2015","journal-title":"Int J Gynecol Pathol."},{"issue":"9","key":"2021122203532416500_CIT0102","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1470-2045(13)70253-5","article-title":"Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study","volume":"14","author":"Sieh","year":"2013","journal-title":"Lancet Oncol."},{"issue":"2","key":"2021122203532416500_CIT0103","first-page":"221","article-title":"Decreased progesterone receptor isoform expression in luteal phase fallopian tube epithelium and high-grade serous carcinoma","volume":"18","author":"Tone","year":"2011","journal-title":"Endocr Relat Cancer."},{"issue":"5","key":"2021122203532416500_CIT0104","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1530\/ERC-11-0107","article-title":"The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer","volume":"18","author":"King","year":"2011","journal-title":"Endocr Relat Cancer."},{"issue":"2","key":"2021122203532416500_CIT0105","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2010.06.014","article-title":"Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis","volume":"7","author":"Mohrin","year":"2010","journal-title":"Cell Stem Cell."},{"issue":"3","key":"2021122203532416500_CIT0106","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.devcel.2019.03.026","article-title":"The Extracellular Matrix Modulates the Metastatic Journey","volume":"49","author":"Kai","year":"2019","journal-title":"Dev Cell."},{"issue":"1","key":"2021122203532416500_CIT0107","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1186\/s12885-019-5925-5","article-title":"NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12\/CXCR4 pathway","volume":"19","author":"Gao","year":"2019","journal-title":"BMC Cancer."},{"issue":"44","key":"2021122203532416500_CIT0108","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1038\/sj.onc.1206828","article-title":"Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL","volume":"22","author":"Syed","year":"2003","journal-title":"Oncogene."},{"issue":"11","key":"2021122203532416500_CIT0109","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.celrep.2017.02.049","article-title":"Progesterone Prevents High-Grade Serous Ovarian Cancer by Inducing Necroptosis of p53-Defective Fallopian Tube Epithelial Cells","volume":"18","author":"Wu","year":"2017","journal-title":"Cell Rep."},{"issue":"7634","key":"2021122203532416500_CIT0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature20785","article-title":"Early dissemination seeds metastasis in breast cancer","volume":"540","author":"Hosseini","year":"2016","journal-title":"Nature."},{"issue":"5","key":"2021122203532416500_CIT0111","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/15384101.2019.1577525","article-title":"DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169","volume":"18","author":"Menon","year":"2019","journal-title":"Cell Cycle."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab195\/38197193\/dgab195.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/7\/1929\/41847729\/dgab195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/7\/1929\/41847729\/dgab195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T07:41:02Z","timestamp":1671694862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/7\/1929\/6184118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":111,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,3,23]]},"published-print":{"date-parts":[[2021,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab195","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,3,23]]}}}