{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:06:31Z","timestamp":1778691991067,"version":"3.51.4"},"reference-count":45,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Health and Medical Research Council of Australia"},{"DOI":"10.13039\/501100015796","name":"Tasmanian Community Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015796","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Masonic Centenary Medical Research Foundation"},{"DOI":"10.13039\/100012503","name":"Royal Hobart Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008158","name":"Arthritis Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25[OH]D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort analysis was conducted of community-dwelling adults aged 50 to 80 years who had 25(OH)D assessed by radioimmunoassay and bone mineral density (BMD) by dual-energy x-ray absorptiometry at baseline (n\u2005=\u20051096), 2.5 (n\u2005=\u2005870), and 10 (n\u2005=\u2005565) years. Sun exposure was quantified by questionnaire and supplement use at clinic review. 25(OH)D less than 50 nmol\/L was considered deficient. Participants were provided with their 25(OH)D results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 10 years 25(OH)D increased (52.2\u2005\u00b1\u200517.0 to 63.5\u2005\u00b1\u200523.6 nmol\/L, P\u2005&amp;lt;\u2005.001). Participants with baseline deficiency had larger 25(OH)D increases than baseline sufficient participants (19.2\u2005\u00b1\u200525.3 vs 1.6\u2005\u00b1\u200523.3 nmol\/L, P\u2005&amp;lt;\u2005.001). Longitudinal change in 25(OH)D was associated with baseline summer (\u03b2\u2005=\u20051.46, P\u2005&amp;lt;\u2005.001) and winter (\u03b2\u2005=\u20051.29, P\u2005=\u2005.003) sun exposure, change in summer (\u03b2\u2005=\u20051.27, P\u2005=\u2005.002) and winter (\u03b2\u2005=\u20051.47, P\u2005&amp;lt;\u2005.001) sun exposure, and vitamin D supplement use (\u03b2\u2005=\u200525.0-33.0, P\u2005&amp;lt;\u2005.001). Persistent vitamin D sufficiency was associated with less BMD loss at the femoral neck (\u03b2\u2005=\u20050.020, P\u2005=\u2005.027), lumbar spine (\u03b2\u2005=\u20050.033, P\u2005=\u2005.003), and total hip (\u03b2\u2005=\u20050.023, P\u2005=\u2005.021) compared to persistent vitamin D deficiency. Achieving vitamin D sufficiency was associated with less BMD loss at the lumbar spine (\u03b2\u2005=\u20050.045, P\u2005&amp;lt;\u2005.001) compared to persistent vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Population 25(OH)D concentration increased because of a combination of increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency was associated with less BMD loss over 10 years.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgab197","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T05:47:03Z","timestamp":1617083223000},"page":"e2995-e3004","source":"Crossref","is-referenced-by-count":8,"title":["Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated With Less BMD Loss Over 10 Years"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-5808","authenticated-orcid":false,"given":"Michael","family":"Thompson","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Tasmania 7000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Aitken","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Tasmania 7000, 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