{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:49Z","timestamp":1790752129382,"version":"4.1.0"},"reference-count":36,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effects of human growth hormone (GH) injections on HV in children with AN and severe growth impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and participants<\/jats:title>\n                  <jats:p>In this prospective, randomized, double-blind, single-center, proof-of-concept trial, children with AN and low HV (\u22642 cm\/year) for at least 18 months, and a bone age \u226412 years for girls and \u226414 years for boys, were randomized to receive daily subcutaneous injections of human GH (0.050 mg\/kg\/day) or placebo for 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Change in HV after 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 8 patients were assigned to the GH group and 6 to the placebo group. Patients had a median (25th-75th percentile) HV of 1.0 (0.5;1.5) cm\/year. The effect of GH treatment increased strongly after 6 months, with a height gain after 12 months of 9.65 (8.0;11.6) cm for the GH group vs 3.85 (1.7;7.3) cm for the placebo group, with an absolute median (2.5th-97.5th percentile) difference between the groups of 5.8 (\u22121.85;9.68) cm after bootstrapping. The percentage of patients with a HV &amp;gt; 5 cm\/year during the study period was higher in the GH group than in the placebo group (100% vs 50%, P = 0.05). Adverse events occurred in similar numbers in the 2 groups, were mild or nonfatal, and did not lead to treatment being stopped.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>GH administration to improve HV is a potentially valid option for increasing HV in children with AN and prolonged severe growth failure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab203","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T05:26:06Z","timestamp":1616822766000},"page":"e2535-e2546","source":"Crossref","is-referenced-by-count":13,"title":["One Year of GH Treatment for Growth Failure in Children With Anorexia Nervosa: A Randomized Placebo-Controlled Trial"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-7341","authenticated-orcid":false,"given":"Juliane","family":"L\u00e9ger","sequence":"first","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Endocrinology-Diabetology Department, Reference Center for Growth and Development Endocrine Diseases, Paris, France"},{"name":"Universit\u00e9 de Paris; NeuroDiderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 1141, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fjellestad-Paulsen","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Endocrinology-Diabetology Department, Reference Center for Growth and Development Endocrine Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bargiacchi","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Child and Adolescent Psychiatry Department, Reference Center for Growth and Development Endocrine Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Pages","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Clinical Epidemiology Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Chevenne","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Biochemistry Unit, Robert Debr\u00e9 University Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Alison","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Pediatric Radiology Department, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Alberti","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Clinical Epidemiology Unit, Paris, France"},{"name":"Inserm, CIC-EC 1426, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guilmin-Crepon","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Clinical Epidemiology Unit, Paris, France"},{"name":"Inserm, CIC-EC 1426, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"key":"2021122203543513500_CIT0001","volume-title":"Diagnostic and Statistical Manual of Mental Disorders. 5th ed. 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