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In the ALSPAC cohort, the polygenic risk score was able to identify children who developed adulthood short stature with an area under the receiver operating characteristic curve (AUROC) of 0.84, which is close to that of mid-parental height. Combining this polygenic risk score with mid-parental height or only one of the child\u2019s parent\u2019s height could improve the AUROC to at most 0.90. The polygenic risk score could also substitute mid-parental height in age-specific Khamis-Roche height predictors and achieve an equally strong discriminative power in identifying children with a short stature in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A polygenic risk score could be considered as an alternative or adjunct to mid-parental height to improve screening for children at risk of developing short stature in adulthood in European ancestry populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab215","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T14:47:00Z","timestamp":1617202020000},"page":"1918-1928","source":"Crossref","is-referenced-by-count":32,"title":["A Polygenic Risk Score to Predict Future Adult Short Stature Among 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