{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:07:17Z","timestamp":1785827237137,"version":"3.56.0"},"reference-count":23,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Preoperative blockade with \u03b1-blockers is recommended in patients with pheochromocytoma\/paraganglioma (PPGL). The data on calcium channel blockade (CCB) in PPGL are scarce.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to compare the efficacy of CCB and \u03b1-blockers on intraoperative hemodynamic instability (HDI) in PPGL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In the interim analysis of this monocentric, pilot, open-label, randomized controlled trial, patients with solitary, secretory, and nonmetastatic PPGL were randomized to oral prazosin gastrointestinal therapeutic system (GITS) (maximum 30 mg, n\u2005=\u20059) or amlodipine (maximum 20 mg, n\u2005=\u200511). The primary outcomes were the episodes and duration of hypertension (systolic blood pressure \u2265\u2005160 mmHg) and hypotension (mean arterial pressure &amp;lt;\u200560 mmHg) and duration of HDI (hypertension and\/or hypotension) as a percentage of total surgical time (from induction of anesthesia to skin closure).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median (IQR) episodes (2 [1-3] vs 0 [0-1]; P = 0.002) and duration of hypertension (19 [14-42] vs 0 [0-3] minutes; P = 0.001) and intraoperative HDI duration (22.85\u2005\u00b1\u200518.4% vs 2.44\u2005\u00b1\u20052.4%; CI, 8.68-32.14%; P 0.002) were significantly higher in the prazosin GITS arm than the amlodipine arm, whereas episodes and duration of hypotension did not differ between the 2 groups. There was no perioperative mortality. One patient had intraoperative ST depression on the electrocardiogram. The drug-related adverse effects were pedal edema (1 in amlodipine), dizziness (1 in prazosin GITS), and tachycardia (6 in prazosin GITS and 3 in amlodipine).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Preoperative blockade with amlodipine is an efficacious alternative to prazosin GITS in preventing intraoperative HDI in PPGL. Larger studies that compare preoperative blockade by amlodipine with other \u03b1-blockers like phenoxybenzamine and\/or doxazosin in PPGL patients are warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab231","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T18:12:35Z","timestamp":1618164755000},"page":"e2907-e2918","source":"Crossref","is-referenced-by-count":21,"title":["Preoperative Amlodipine Is Efficacious in Preventing Intraoperative HDI in Pheochromocytoma: Pilot RCT"],"prefix":"10.1210","volume":"106","author":[{"given":"Sanjeet Kumar","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra 400012,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba Samad","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra 400012,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-4471","authenticated-orcid":false,"given":"Anurag","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra 400012,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-0448","authenticated-orcid":false,"given":"Vijaya","family":"Sarathi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka 560066, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath","family":"Goroshi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jawaharlal Nehru Medical College, Belagavi, Karnataka 590010, 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