{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:38:59Z","timestamp":1790908739729,"version":"4.1.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of fibroblast growth factor 23. The only curative therapy is resection of the causative tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This research was conducted to evaluate the efficacy of 18F-AlF-NOTA-octreotide (18F-OC) positron emission tomography\/computed tomography (PET\/CT) in detecting TIO and its impact on patient management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective analysis was conducted of 17 patients with hypophosphatemic osteomalacia suspected to be TIO. A \u200a18F-OC PET\/CT study was performed in all 17 patients to localize the tumor and 68Ga-DOTATATE PET\/CT was performed in 4 out of 17 patients; both studies were performed within 1 week of each other. Both studies were interpreted blindly without the knowledge of other imaging findings. The image findings were compared with the results of histopathological examinations and clinical follow-ups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 18F-OC PET\/CT scans were positive in 14 patients. Furthermore, 4 of 14 patients were scanned with both 18F-OC and 68Ga-DOTATATE PET\/CT. Both studies were able to localize the tumor in all 4 patients. In total, 14 patients had surgery to remove the lesions. Postsurgical pathological examination confirmed causative tumors in these patients, whose symptoms diminished promptly. Serum phosphate levels normalized, confirming the diagnosis of TIO. 18F-OC PET\/CT sensitivity, specificity, and accuracy were 87.5%, 100%, and 88.2% respectively. 18F-OC PET\/CT findings affected patient management in 88.2% of cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>18F-OC PET\/CT scan is useful in the detection of tumors causing TIO. Further studies with larger patient populations are needed to validate the result.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab258","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T15:53:25Z","timestamp":1618674805000},"page":"e4202-e4209","source":"Crossref","is-referenced-by-count":15,"title":["Utility of 18F-AlF-NOTA-Octreotide PET\/CT in the Localization of Tumor-Induced Osteomalacia"],"prefix":"10.1210","volume":"106","author":[{"given":"Tingting","family":"Long","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, 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