{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:20:14Z","timestamp":1776216014151,"version":"3.50.1"},"reference-count":54,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16FTF30130005"],"award-info":[{"award-number":["16FTF30130005"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18SFRN34230089"],"award-info":[{"award-number":["18SFRN34230089"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-GM13079"],"award-info":[{"award-number":["R01-GM13079"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL142856"],"award-info":[{"award-number":["R01-HL142856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32-GM007569"],"award-info":[{"award-number":["T32-GM007569"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K12-HD04348"],"award-info":[{"award-number":["K12-HD04348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shared Instrumentation Grants","award":["S10OD017985"],"award-info":[{"award-number":["S10OD017985"]}]},{"name":"Shared Instrumentation Grants","award":["S10RR025141"],"award-info":[{"award-number":["S10RR025141"]}]},{"name":"Clinical and Translational Science Award","award":["UL1TR002243"],"award-info":[{"award-number":["UL1TR002243"]}]},{"name":"Clinical and Translational Science Award","award":["UL1TR000445"],"award-info":[{"award-number":["UL1TR000445"]}]},{"name":"Clinical and Translational Science Award","award":["UL1RR024975"],"award-info":[{"award-number":["UL1RR024975"]}]},{"name":"Clinical and Translational Science Award","award":["U01HG004798"],"award-info":[{"award-number":["U01HG004798"]}]},{"name":"Clinical and Translational Science Award","award":["R01NS032830"],"award-info":[{"award-number":["R01NS032830"]}]},{"name":"Clinical and Translational Science Award","award":["RC2GM092618"],"award-info":[{"award-number":["RC2GM092618"]}]},{"name":"Clinical and Translational Science Award","award":["P50GM115305"],"award-info":[{"award-number":["P50GM115305"]}]},{"name":"Clinical and Translational Science Award","award":["U01HG006378"],"award-info":[{"award-number":["U01HG006378"]}]},{"name":"Clinical and Translational Science Award","award":["U19HL065962"],"award-info":[{"award-number":["U19HL065962"]}]},{"name":"Clinical and Translational Science Award","award":["R01HD074711"],"award-info":[{"award-number":["R01HD074711"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>A genetic predisposition to lower thyrotropin (TSH) levels is associated with increased atrial fibrillation (AF) risk through undefined mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Defining the genetic mediating mechanisms could lead to improved targeted therapies to mitigate AF risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used 2-sample mendelian randomization (MR) to test associations between TSH-associated single-nucleotide variations and 16 candidate mediators. We then performed multivariable mendelian randomization (MVMR) to test for a significant attenuation of the genetic association between TSH and AF, after adjusting for each mediator significantly associated with TSH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four candidate mediators (free thyroxine, systolic blood pressure, heart rate, and height) were significantly inversely associated with genetically predicted TSH after adjusting for multiple testing. In MVMR analyses, adjusting for height significantly decreased the magnitude of the association between TSH and AF from \u20130.12 (SE 0.02) occurrences of AF per SD change in height to \u20130.06 (0.02) (P\u2005=\u2005.005). Adjusting for the other candidate mediators did not significantly attenuate the association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The genetic association between TSH and increased AF risk is mediated, in part, by taller stature. Thus, some genetic mechanisms underlying TSH variability may contribute to AF risk through mechanisms determining height occurring early in life that differ from those driven by thyroid hormone\u2013level elevations in later life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab272","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:34:47Z","timestamp":1619310887000},"page":"2124-2132","source":"Crossref","is-referenced-by-count":13,"title":["Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-9822","authenticated-orcid":false,"given":"Mingjian","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics & Center for Precision Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M","family":"Manouchehri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataraja Sarma","family":"Vaitinadin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacklyn N","family":"Hellwege","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe-Elie","family":"Salem","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie, APHP, Sorbonne Universit\u00e9, INSERM, UNICO-GRECO Cardio-oncology Program , F75013 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea K","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill H","family":"Simmons","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics & Center for Precision Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]},{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]},{"name":"Department of Pharmacology, Vanderbilt University , Nashville, Tennessee 37212 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Benjamin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane F","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics & Center for Precision Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]},{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,4,25]]},"reference":[{"issue":"2","key":"2026041420193462900_CIT0001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol Rev."},{"issue":"4","key":"2026041420193462900_CIT0002","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/er.2018-00275","article-title":"Paradigms of dynamic control of thyroid hormone signaling","volume":"40","author":"Bianco","year":"2019","journal-title":"Endocr Rev."},{"issue":"2","key":"2026041420193462900_CIT0003","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/jamacardio.2018.4615","article-title":"Association of thyroid function genetic predictors with atrial fibrillation: a phenome-wide association study and inverse-variance weighted average meta-analysis","volume":"4","author":"Salem","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"2","key":"2026041420193462900_CIT0004","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2018.4635","article-title":"Assessment of the relationship between genetic determinants of thyroid function and atrial fibrillation: a mendelian randomization study","volume":"4","author":"Ellervik","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"1","key":"2026041420193462900_CIT0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/jce.14183","article-title":"Free thyroxine within the normal reference range predicts risk of atrial fibrillation","volume":"31","author":"Anderson","year":"2020","journal-title":"J Cardiovasc Electrophysiol."},{"issue":"10","key":"2026041420193462900_CIT0006","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics\u20142019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation."},{"issue":"2","key":"2026041420193462900_CIT0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/CIRCRESAHA.120.316756","article-title":"Association between atrial fibrillation and sudden cardiac death","volume":"127","author":"Waldmann","year":"2020","journal-title":"Circ Res."},{"issue":"1","key":"2026041420193462900_CIT0008","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/CIRCRESAHA.120.316340","article-title":"Epidemiology of atrial fibrillation in the 21st century: novel methods and new insights","volume":"127","author":"Kornej","year":"2020","journal-title":"Circ Res."},{"issue":"5","key":"2026041420193462900_CIT0009","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jacc.2019.11.046","article-title":"Cardiometabolic-based chronic disease, addressing knowledge and clinical practice gaps: JACC state-of-the-art review","volume":"75","author":"Mechanick","year":"2020","journal-title":"J Am Coll Cardiol."},{"issue":"6","key":"2026041420193462900_CIT0010","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data","volume":"46","author":"Yavorska","year":"2017","journal-title":"Int J Epidemiol."},{"issue":"3","key":"2026041420193462900_CIT0011","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ije\/dyy262","article-title":"An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings","volume":"48","author":"Sanderson","year":"2019","journal-title":"Int J Epidemiol."},{"issue":"8","key":"2026041420193462900_CIT0012","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/clinem\/dgaa239","article-title":"Thyroid function affects the risk of stroke via atrial fibrillation: a mendelian randomization study","volume":"105","author":"Marouli","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2026041420193462900_CIT0013","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"Teumer","year":"2018","journal-title":"Nat Commun."},{"issue":"6","key":"2026041420193462900_CIT0014","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.3843","article-title":"Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation","volume":"49","author":"Christophersen","year":"2017","journal-title":"Nat Genet."},{"issue":"12","key":"2026041420193462900_CIT0015","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/ng.3708","article-title":"Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality","volume":"48","author":"Eppinga","year":"2016","journal-title":"Nat Genet."},{"issue":"1","key":"2026041420193462900_CIT0016","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1038\/s41598-020-64525-z","article-title":"The polygenic architecture of left ventricular mass mirrors the clinical epidemiology","volume":"10","author":"Mosley","year":"2020","journal-title":"Sci Rep."},{"issue":"1","key":"2026041420193462900_CIT0017","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1038\/s41467-020-15706-x","article-title":"Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction","volume":"11","author":"Ntalla","year":"2020","journal-title":"Nat Commun."},{"issue":"13","key":"2026041420193462900_CIT0018","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jacc.2016.07.729","article-title":"52 genetic loci influencing myocardial mass","volume":"68","author":"van der Harst","year":"2016","journal-title":"J Am Coll Cardiol."},{"issue":"8","key":"2026041420193462900_CIT0019","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ng.3014","article-title":"Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization","volume":"46","author":"Arking","year":"2014","journal-title":"Nat Genet."},{"issue":"1","key":"2026041420193462900_CIT0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41588-017-0011-x","article-title":"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity","volume":"50","author":"Turcot","year":"2018","journal-title":"Nat Genet."},{"issue":"20","key":"2026041420193462900_CIT0021","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in ~700000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum Mol Genet."},{"issue":"7538","key":"2026041420193462900_CIT0022","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14132","article-title":"New genetic loci link adipose and insulin biology to body fat distribution","volume":"518","author":"Shungin","year":"2015","journal-title":"Nature."},{"issue":"1","key":"2026041420193462900_CIT0023","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41588-018-0303-9","article-title":"Trans-ethnic association study of blood pressure determinants in over 750,000 individuals","volume":"51","author":"Giri","year":"2019","journal-title":"Nat Genet."},{"issue":"2","key":"2026041420193462900_CIT0024","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ng.520","article-title":"New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk","volume":"42","author":"Dupuis","year":"2010","journal-title":"Nat Genet."},{"issue":"11","key":"2026041420193462900_CIT0025","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nat Genet."},{"issue":"1","key":"2026041420193462900_CIT0026","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41467-019-13690-5","article-title":"Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure","volume":"11","author":"Shah","year":"2020","journal-title":"Nat Commun."},{"issue":"3","key":"2026041420193462900_CIT0027","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/clpt.2008.89","article-title":"Development of a large-scale de-identified DNA biobank to enable personalized medicine","volume":"84","author":"Roden","year":"2008","journal-title":"Clin Pharmacol Ther."},{"issue":"11","key":"2026041420193462900_CIT0028","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3679","article-title":"Reference-based phasing using the Haplotype Reference Consortium panel","volume":"48","author":"Loh","year":"2016","journal-title":"Nat Genet."},{"issue":"24","key":"2026041420193462900_CIT0029","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1093\/bioinformatics\/bts606","article-title":"A high-performance computing toolset for relatedness and principal component analysis of SNP data","volume":"28","author":"Zheng","year":"2012","journal-title":"Bioinformatics."},{"issue":"7","key":"2026041420193462900_CIT0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrg.2016.27","article-title":"Developing and evaluating polygenic risk prediction models for stratified disease prevention","volume":"17","author":"Chatterjee","year":"2016","journal-title":"Nat Rev Genet."},{"issue":"5","key":"2026041420193462900_CIT0031","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet."},{"issue":"1","key":"2026041420193462900_CIT0032","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-017-02317-2","article-title":"Causal associations between risk factors and common diseases inferred from GWAS summary data","volume":"9","author":"Zhu","year":"2018","journal-title":"Nat Commun."},{"issue":"3","key":"2026041420193462900_CIT0033","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10654-021-00721-z","article-title":"Thyroid function, sex hormones and sexual function: a mendelian randomization study","volume":"36","author":"Kjaergaard","year":"2021","journal-title":"Eur J Epidemiol."},{"issue":"4","key":"2026041420193462900_CIT0034","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol."},{"key":"2026041420193462900_CIT0035","author":"Shi"},{"issue":"7","key":"2026041420193462900_CIT0036","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein","year":"2001","journal-title":"N Engl J Med."},{"issue":"25","key":"2026041420193462900_CIT0037","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1056\/NEJMcp1709318","article-title":"Subclinical hyperthyroidism","volume":"378","author":"Biondi","year":"2018","journal-title":"N Engl J Med."},{"issue":"7","key":"2026041420193462900_CIT0038","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S2213-8587(17)30402-3","article-title":"Autoimmune thyroid disease during pregnancy","volume":"6","author":"De Leo","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"1","key":"2026041420193462900_CIT0039","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12020-019-02024-6","article-title":"Thyroid hormone therapy in congenital hypothyroidism and pediatric hypothyroidism","volume":"66","author":"Bauer","year":"2019","journal-title":"Endocrine."},{"issue":"4","key":"2026041420193462900_CIT0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40272-017-0238-0","article-title":"Pediatric hypothyroidism: diagnosis and treatment","volume":"19","author":"Wassner","year":"2017","journal-title":"Paediatr Drugs."},{"issue":"2","key":"2026041420193462900_CIT0041","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4274\/jcrpe.v3i2.11","article-title":"Thyroid hormones and growth in health and disease","volume":"3","author":"Tar\u0131m","year":"2011","journal-title":"J Clin Res Pediatr Endocrinol."},{"key":"2026041420193462900_CIT0042","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2020.01.017","article-title":"Height is associated with incident atrial fibrillation in a large Asian cohort","volume":"304","author":"Park","year":"2020","journal-title":"Int J Cardiol."},{"issue":"21","key":"2026041420193462900_CIT0043","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1093\/eurheartj\/ehs301","article-title":"The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study","volume":"33","author":"Rosenberg","year":"2012","journal-title":"Eur Heart J."},{"issue":"2","key":"2026041420193462900_CIT0044","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/aje\/kwu126","article-title":"Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study","volume":"180","author":"Rosenberg","year":"2014","journal-title":"Am J Epidemiol."},{"issue":"10","key":"2026041420193462900_CIT0045","doi-asserted-by":"crossref","first-page":"e1003288","DOI":"10.1371\/journal.pmed.1003288","article-title":"Genetics of height and risk of atrial fibrillation: a mendelian randomization study","volume":"17","author":"Levin","year":"2020","journal-title":"PloS Med."},{"issue":"1","key":"2026041420193462900_CIT0046","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/europace\/eum263","article-title":"Physical activity, height, and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals","volume":"10","author":"Mont","year":"2008","journal-title":"Europace."},{"issue":"1","key":"2026041420193462900_CIT0047","doi-asserted-by":"crossref","first-page":"e004735","DOI":"10.1161\/CIRCEP.116.004735","article-title":"Relationships of measured and genetically determined height with the cardiac conduction system in healthy adults","volume":"10","author":"Kofler","year":"2017","journal-title":"Circ Arrhythm Electrophysiol."},{"issue":"24","key":"2026041420193462900_CIT0048","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1001\/jama.2009.888","article-title":"Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block","volume":"301","author":"Cheng","year":"2009","journal-title":"JAMA."},{"issue":"1","key":"2026041420193462900_CIT0049","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1677\/JOE-09-0262","article-title":"TSH receptor activation and body composition","volume":"204","author":"de Lloyd","year":"2010","journal-title":"J Endocrinol."},{"issue":"2","key":"2026041420193462900_CIT0050","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0735-1097(01)01731-4","article-title":"Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytes","volume":"39","author":"Chen","year":"2002","journal-title":"J Am Coll Cardiol."},{"issue":"11","key":"2026041420193462900_CIT0051","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.amjcard.2019.08.025","article-title":"Resting heart rate, short-term heart rate variability and incident atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis (MESA))","volume":"124","author":"Habibi","year":"2019","journal-title":"Am J Cardiol."},{"issue":"22","key":"2026041420193462900_CIT0052","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1161\/CIRCULATIONAHA.117.028753","article-title":"Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation","volume":"136","author":"Baumgartner","year":"2017","journal-title":"Circulation."},{"issue":"9","key":"2026041420193462900_CIT0053","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/CIRCULATIONAHA.120.049819","article-title":"Linear and nonlinear mendelian randomization analyses of the association between diastolic blood pressure and cardiovascular events: the J-curve revisited","volume":"143","author":"Arvanitis","year":"2021","journal-title":"Circulation."},{"issue":"10","key":"2026041420193462900_CIT0054","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s40618-019-01030-9","article-title":"Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone","volume":"42","author":"Popovi\u0107","year":"2019","journal-title":"J Endocrinol Invest."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab272\/38101703\/dgab272.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/7\/2124\/38663272\/dgab272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/7\/2124\/38663272\/dgab272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:38:35Z","timestamp":1776213515000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/7\/2124\/6250092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,25]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4,25]]},"published-print":{"date-parts":[[2021,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab272","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,4,25]]}}}