{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:58:16Z","timestamp":1790423896830,"version":"4.1.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["D43 TW009118"],"award-info":[{"award-number":["D43 TW009118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Guidelines for the dosage of vitamin D supplementation vary widely globally.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the impact of 2 vitamin D doses, bracketed between the IOM recommended dietary allowance (RDA) and the upper tolerable limit, on vitamin D nutritional status in elderly individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This post hoc analysis of data collected from a 12-month, double-blind, randomized control trial included 221 ambulatory participants (\u2265 65 years) with a mean BMI of 30.2 kg\/m2 and a mean baseline serum 25-hydroxyvitamin D [25(OH)D] level of 20.4\u2005\u00b1\u20057.4 ng\/mL, who were recruited from 3 outpatient centers in Lebanon. All participants received 1000 mg of elemental calcium daily from calcium citrate plus the daily equivalent of either 600 IU or 3750 IU of vitamin D3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean 25(OH)D level at 12 months was 26.0 ng\/mL with low dose and 36.0 ng\/mL with high dose vitamin D3. The proportion of participants reaching a value \u2265 20 ng\/mL was 86% in the low dose, and 99% in the high dose arms, with no gender differences. The increment of 25(OH)D per 100 IU\/day was 1 ng\/mL with the low dose, and 0.41 ng\/mL with the high dose. Serum 25(OH)D levels at 1 year were highly variable in both treatment arms. Baseline 25(OH)D level and vitamin D dose\u2014but not age, BMI, gender, or season\u2014were significant predictors of serum 25(OH)D level post-intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The IOM Recommended Dietary Allowance (RDA) of 600 IU\/day does not bring 97.5% of ambulatory elderly individuals above the desirable threshold of 20 ng\/mL. Country-specific RDAs are best derived taking into account the observed variability and predictors of achieved 25(OH)D levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab296","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T19:25:03Z","timestamp":1620329103000},"page":"e3644-e3654","source":"Crossref","is-referenced-by-count":15,"title":["Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-9021","authenticated-orcid":false,"given":"Dania S","family":"Bacha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Rahme","sequence":"additional","affiliation":[{"name":"Department of Internal 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Clinical Biochemistry and Immunology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad R","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medicine, NY, USA"},{"name":"Weill Cornell Medicine, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Habib","sequence":"additional","affiliation":[{"name":"STS Research Center, The Society of Thoracic Surgeons, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Arabi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-5858","authenticated-orcid":false,"given":"Ghada","family":"El-Hajj 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