{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:03:29Z","timestamp":1789232609276,"version":"build-2803163510"},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"High Technology Research Center Grant"},{"name":"Strategic Research Foundation at Private Universities"},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["23680069"],"award-info":[{"award-number":["23680069"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["26282197"],"award-info":[{"award-number":["26282197"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["17K19929"],"award-info":[{"award-number":["17K19929"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>A recent meta-analysis of genome-wide association studies data from East Asians identified aldehyde dehydrogenase 2 (ALDH2) rs671 as a susceptibility variant for type 2 diabetes in males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the association between ALDH2 rs671 and metabolic characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied 94 nonobese, nondiabetic, Japanese men. Using a 2-step hyperinsulinemic-euglycemic clamp, we evaluated insulin sensitivity in muscle and liver. Intrahepatic lipid and fat distribution were measured using 1H-magnetic resonance spectroscopy and magnetic resonance imaging, respectively. We divided participants into a risk-carrying group with ALDH2 rs671 G\/G (n\u2005=\u200553) and a nonrisk-carrying group with ALDH2 rs671 G\/A or A\/A (n\u2005=\u200541).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The risk-carrying group had significantly higher levels of alcohol consumption (18.4 [interquartile range, IQR, 10.4-48.9]) vs 12.1 (IQR, 1.3-29.0) g\/day; P\u2005=\u2005.003), elevated fasting plasma glucose (FPG) (97.5\u2005\u00b1\u20057.9 vs 93.5\u2005\u00b1\u20056.2 mg\/dL; P\u2005=\u2005.010), lower hepatic insulin sensitivity (61.7\u2005\u00b1\u200520.5% vs 73.1\u2005\u00b1\u200515.9%; P\u2005=\u2005.003), and lower fasting glucose clearance (0.84\u2005\u00b1\u20050.8 dL\u00b7m\u20132\u00b7min\u20131 vs 0.87\u2005\u00b1\u20050.09 dL\u00b7m\u20132\u00b7min\u20131; P\u2005=\u2005.047) than the nonrisk-carrying group, while insulin resistance in muscle and body fat distribution were similar. The single linear correlation analysis revealed significant correlations between alcohol consumption and hepatic insulin sensitivity (r\u2005=\u2005\u20130.262, P\u2005=\u2005.011), fasting glucose clearance (r\u2005=\u2005\u20130.370, P\u2005&amp;lt;\u2005.001), or FPG (r\u2005=\u20050.489, P\u2005&amp;lt;\u2005.001). The multiple regression analysis revealed that both ALDH2 rs671 G\/G genotype and alcohol consumption were significant independent correlates for hepatic insulin sensitivity, whereas only alcohol consumption was a significant independent correlate for fasting glucose clearance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our data suggest that high-alcohol intake\u2013dependent and independent hepatic insulin resistance and reduced fasting glucose clearance due to high alcohol intake could be a relatively upstream metabolic abnormality in ALDH2 rs671 G\/G carriers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab324","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T16:06:32Z","timestamp":1620749192000},"page":"e3573-e3581","source":"Crossref","is-referenced-by-count":17,"title":["<i>ALDH2<\/i> rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men"],"prefix":"10.1210","volume":"106","author":[{"given":"Kageumi","family":"Takeno","sequence":"first","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7821","authenticated-orcid":false,"given":"Yoshifumi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Kakehi","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyoshi","family":"Kaga","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Kawamori","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-1816","authenticated-orcid":false,"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"issue":"20","key":"2021120108561364100_CIT0001","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1001\/jama.2009.726","article-title":"Diabetes in Asia: 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