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The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.<\/jats:p>","DOI":"10.1210\/clinem\/dgab333","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T23:57:21Z","timestamp":1620863841000},"page":"2147-2163","source":"Crossref","is-referenced-by-count":36,"title":["New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-2702","authenticated-orcid":false,"given":"Logan K","family":"Townsend","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, L8S 4L8, Canada"},{"name":"Department of Human Health and Nutritional Science, University of Guelph, Guelph, N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E K","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Centre for Neuroscience, Brock University, St. Catharines, L2S 3A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-8901","authenticated-orcid":false,"given":"David C","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Science, University of Guelph, Guelph, N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"issue":"6","key":"2021071319515909500_CIT0001","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1152\/japplphysiol.00925.2007","article-title":"Susruta of India, an unrecognized contributor to the history of exercise physiology","volume":"104","author":"Tipton","year":"2008","journal-title":"J Appl Physiol 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