{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:30:03Z","timestamp":1785331803293,"version":"3.55.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC1001004"],"award-info":[{"award-number":["2017YFC1001004"]}]},{"name":"National Key R&D Program of China","award":["2018YFC1003202"],"award-info":[{"award-number":["2018YFC1003202"]}]},{"name":"Taishan Scholar Project Special Funds of China","award":["ts201712103)"],"award-info":[{"award-number":["ts201712103)"]}]},{"name":"Shandong Provincial Key Research and Development Program of China","award":["2018YFJH0504"],"award-info":[{"award-number":["2018YFJH0504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve live birth rate among overweight or obese women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a randomized, double-blinded, placebo-controlled trial across 19 reproductive medical centers in China, from July 2017 to January 2019. A total of 877 infertile women scheduled for IVF who had a body mass index of 25 or greater were randomly assigned to receive orlistat (n\u2005=\u2005439) or placebo (n\u2005=\u2005438) treatment for 4 to 12 weeks. The main outcome measurement was the live birth rate after fresh ET.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The live birth rate was not significantly different between the 2 groups (112 of 439 [25.5%] with orlistat and 112 of 438 [25.6%] with placebo; P\u2005=\u2005.984). No significant differences existed between the groups as to the rates of conception, clinical pregnancy, or pregnancy loss. A statistically significant increase in singleton birth weight was observed after orlistat treatment (3487.50 g vs 3285.17 g in the placebo group; P\u2005=\u2005.039). The mean change in body weight during the intervention was \u22122.49 kg in the orlistat group, as compared to \u22121.22 kg in the placebo group, with a significant difference (P\u2005=\u2005.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Orlistat treatment, prior to IVF-ET, did not improve the live birth rate among overweight or obese women, although it was beneficial for weight reduction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab340","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T15:58:26Z","timestamp":1621094306000},"page":"e3533-e3545","source":"Crossref","is-referenced-by-count":33,"title":["Effect of Orlistat on Live Birth Rate in Overweight or Obese Women Undergoing IVF-ET: A Randomized Clinical Trial"],"prefix":"10.1210","volume":"106","author":[{"given":"Ze","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, General Hospital of Ningxia Medical University, Ningxia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University\/Jiangsu Province Hospital; State Key Laboratory of Reproductive Medicine, Nanjing, Jiangsu Province, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Ren Ji Hospital; School of Medicine, Shanghai Jiao Tong University; Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimin","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Ren","sequence":"additional","affiliation":[{"name":"Reproductive Hospital of Weifang Medical University, Weifang, Shandong Province, 261031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lu","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Peking University People\u2019s Hospital, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Maternity and Child Health Care Hospital, Women\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuifang","family":"Hao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong Province, 264000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Maternal and Child Health Hospital\/Obstetrics and Gynecology Hospital of Guangxi Zhuang Autonomous Region, Guangxi, 530000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Shenyang 204 Hospital, Shenyang, Liaoning Province, 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9587-1535","authenticated-orcid":false,"given":"Dongzi","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchu","family":"Bao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong Province, 264000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Linyi People\u2019 Hospital, Linyi, Shandong Province, 276000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Center for Reproductive Medicine\/Department of Fetal Medicine and Prenatal Diagnosis\/BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Tan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-4031","authenticated-orcid":false,"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"issue":"9945","key":"2021120108561666200_CIT0001","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet."},{"issue":"2","key":"2021120108561666200_CIT0002","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/humrep\/dem371","article-title":"Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women","volume":"23","author":"van der Steeg","year":"2008","journal-title":"Hum Reprod."},{"key":"2021120108561666200_CIT0003","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/nure.12056","article-title":"Weighing the impact of obesity on female reproductive function and fertility","volume":"71","author":"Jungheim","year":"2013","journal-title":"Nutr Rev."},{"issue":"5","key":"2021120108561666200_CIT0004","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/humupd\/dmm017","article-title":"Effect of overweight and obesity on assisted reproductive technology\u2014a systematic review","volume":"13","author":"Maheshwari","year":"2007","journal-title":"Hum Reprod Update."},{"issue":"4","key":"2021120108561666200_CIT0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humupd\/dmz011","article-title":"Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis","volume":"25","author":"Sermondade","year":"2019","journal-title":"Hum Reprod Update."},{"issue":"22","key":"2021120108561666200_CIT0006","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1001\/jama.2013.6295","article-title":"Maternal obesity and risk of preterm delivery","volume":"309","author":"Cnattingius","year":"2013","journal-title":"JAMA."},{"issue":"15","key":"2021120108561666200_CIT0007","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1001\/jama.2014.2269","article-title":"Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis","volume":"311","author":"Aune","year":"2014","journal-title":"JAMA."},{"issue":"6","key":"2021120108561666200_CIT0008","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2009.113","article-title":"Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis","volume":"301","author":"Stothard","year":"2009","journal-title":"JAMA."},{"issue":"5","key":"2021120108561666200_CIT0009","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.fertnstert.2014.01.036","article-title":"A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility","volume":"101","author":"Kort","year":"2014","journal-title":"Fertil Steril."},{"issue":"5","key":"2021120108561666200_CIT0010","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.fertnstert.2015.08.018","article-title":"Obesity and reproduction: a committee opinion","volume":"104","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2015","journal-title":"Fertil Steril"},{"issue":"9","key":"2021120108561666200_CIT0011","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod."},{"issue":"7","key":"2021120108561666200_CIT0012","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/jc.2016-1659","article-title":"Benefit of delayed fertility therapy with preconception weight loss over immediate therapy in obese women with PCOS","volume":"101","author":"Legro","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021120108561666200_CIT0013","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/humupd\/dmx027","article-title":"How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence","volume":"23","author":"Best","year":"2017","journal-title":"Hum Reprod Update."},{"issue":"20","key":"2021120108561666200_CIT0014","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1056\/NEJMoa1505297","article-title":"Randomized trial of a lifestyle program in obese infertile women","volume":"374","author":"Mutsaerts","year":"2016","journal-title":"N Engl J Med."},{"issue":"8","key":"2021120108561666200_CIT0015","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1093\/humrep\/dex235","article-title":"Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial","volume":"32","author":"Einarsson","year":"2017","journal-title":"Hum Reprod."},{"issue":"10031","key":"2021120108561666200_CIT0016","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0140-6736(16)00271-3","article-title":"Management of obesity","volume":"387","author":"Bray","year":"2016","journal-title":"Lancet."},{"issue":"9123","key":"2021120108561666200_CIT0017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(97)11509-4","article-title":"Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group","volume":"352","author":"Sj\u00f6str\u00f6m","year":"1998","journal-title":"Lancet."},{"issue":"3","key":"2021120108561666200_CIT0018","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.281.3.235","article-title":"Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial","volume":"281","author":"Davidson","year":"1999","journal-title":"JAMA."},{"key":"2021120108561666200_CIT0019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.phrs.2017.05.022","article-title":"Effect of orlistat on plasma lipids and body weight: a systematic review and meta-analysis of 33 randomized controlled trials","volume":"122","author":"Sahebkar","year":"2017","journal-title":"Pharmacol Res."},{"issue":"1","key":"2021120108561666200_CIT0020","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s13063-018-2780-7","article-title":"Effect of preconceptional orlistat treatment on in-vitro fertilization outcome in overweight\/obese women: study protocol for a randomized controlled trial","volume":"19","author":"Li","year":"2018","journal-title":"Trials."},{"issue":"8","key":"2021120108561666200_CIT0021","doi-asserted-by":"crossref","first-page":"e104779","DOI":"10.1371\/journal.pone.0104779","article-title":"Birth weight reference percentiles for Chinese","volume":"9","author":"Dai","year":"2014","journal-title":"PloS One."},{"issue":"6","key":"2021120108561666200_CIT0022","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/07853890.2017.1294258","article-title":"Population-based birth weight reference percentiles for Chinese twins","volume":"49","author":"Dai","year":"2017","journal-title":"Ann Med."},{"issue":"4","key":"2021120108561666200_CIT0023","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.fertnstert.2018.05.029","article-title":"Successful weight loss interventions before in vitro fertilization: fat chance?","volume":"110","author":"Norman","year":"2018","journal-title":"Fertil Steril."},{"issue":"23","key":"2021120108561666200_CIT0024","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1001\/jama.293.23.2873","article-title":"Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial","volume":"293","author":"Chanoine","year":"2005","journal-title":"JAMA."},{"issue":"5","key":"2021120108561666200_CIT0025","first-page":"663","article-title":"Determinants of low birth weight: methodological assessment and meta-analysis","volume":"65","author":"Kramer","year":"1987","journal-title":"Bull World Health Organ."},{"issue":"1","key":"2021120108561666200_CIT0026","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1186\/s12884-020-03323-x","article-title":"Association among pre-pregnancy body mass index, gestational weight gain and neonatal birth weight: a prospective cohort study in China","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Pregnancy Childbirth."},{"issue":"21","key":"2021120108561666200_CIT0027","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1001\/jama.2017.3635","article-title":"Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis","volume":"317","author":"Goldstein","year":"2017","journal-title":"JAMA."},{"issue":"17","key":"2021120108561666200_CIT0028","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1001\/jama.2019.3820","article-title":"Association of gestational weight gain with adverse maternal and infant outcomes","volume":"321","author":"LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group;","year":"2019","journal-title":"JAMA"},{"issue":"10","key":"2021120108561666200_CIT0029","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/humrep\/deu218","article-title":"Improving the reporting of clinical trials of infertility treatments (IMPRINT): modifying the CONSORT statement","volume":"29","author":"Harbin Consensus Conference Workshop Group, Conference Chairs","year":"2014","journal-title":"Hum Reprod"},{"issue":"6","key":"2021120108561666200_CIT0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/1389202920666191030092225","article-title":"Maternal obesity, maternal overnutrition and fetal programming: effects of epigenetic mechanisms on the development of metabolic disorders","volume":"20","author":"\u015eanl\u0131","year":"2019","journal-title":"Curr Genomics."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab340\/38826464\/dgab340.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/9\/e3533\/41379110\/dgab340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/9\/e3533\/41379110\/dgab340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T13:58:39Z","timestamp":1638367119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/9\/e3533\/6276241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5,15]]},"published-print":{"date-parts":[[2021,8,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab340","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,5,15]]}}}