{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:36:19Z","timestamp":1791855379054,"version":"4.3.4"},"reference-count":46,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"SPARK BIH Validation Fund Track 2 and German Research Foundation","award":["KU 2673\/6-1"],"award-info":[{"award-number":["KU 2673\/6-1"]}]},{"name":"SPARK BIH Validation Fund Track 2 and German Research Foundation","award":["KU-2673\/2-2"],"award-info":[{"award-number":["KU-2673\/2-2"]}]},{"name":"SPARK BIH Validation Fund Track 2 and German Research Foundation","award":["KU-2673-7-1"],"award-info":[{"award-number":["KU-2673-7-1"]}]},{"name":"SPARK BIH Validation Fund Track 2 and German Research Foundation","award":["CRC1423 (B02)"],"award-info":[{"award-number":["CRC1423 (B02)"]}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1DK070332"],"award-info":[{"award-number":["RO1DK070332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Pro-opiomelanocortin (POMC) and the melanocortin-4 receptor (MC4R) play a pivotal role in the leptin\u2013melanocortin pathway. Mutations in these genes lead to monogenic types of obesity due to severe hyperphagia. In addition to dietary-induced obesity, a cardiac phenotype without hypertrophy has been identified in MC4R knockout mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to characterize cardiac morphology and function as well as tissue Na+ content in humans with mutations in POMC and MC4R genes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 42 patients (5 patients with bi-allelic POMC mutations, 6 heterozygous MC4R mutation carriers, 19 obese controls without known monogenic cause, and 12 normal weight controls) underwent cardiac magnetic resonance (CMR) imaging and 23Na-MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Monogenic obese patients with POMC or MC4R mutation respectively had a significantly lower left ventricular mass\/body surface area (BSA) than nonmonogenic obese patients. Left ventricular end-diastolic volume\/BSA was significantly lower in POMC- and MC4R-deficient patients than in nonmonogenic obese patients. Subcutaneous fat and skin Na+ content was significantly higher in POMC- and MC4R-deficient patients than in nonmonogenic obese patients. In these compartments, the water content was significantly higher in patients with POMC and MC4R mutation than in control groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with POMC or MC4R mutations carriers had a lack of transition to hypertrophy, significantly lower cardiac muscle mass\/BSA, and stored more Na+ within the subcutaneous fat tissue than nonmonogenic obese patients. The results point towards the role of the melanocortin pathway for cardiac function and tissue Na+ storage and the importance of including cardiologic assessments into the diagnostic work-up of these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab368","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T07:22:29Z","timestamp":1622013749000},"page":"2606-2616","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System"],"prefix":"10.1210","volume":"106","author":[{"given":"Lia","family":"Puder","sequence":"first","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Institute for Experimental Pediatric Endocrinology, Berlin 13353, Germany"},{"name":"Department for Pediatric Endocrinology and Diabetology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Roth","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Krabusch","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Institute for Experimental Pediatric Endocrinology, Berlin 13353, Germany"},{"name":"Department for Pediatric Endocrinology and Diabetology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Center for Social-Pediatric Care\/Pediatric Endocrinology and Diabetology, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Opitz","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Institute for Experimental Pediatric Endocrinology, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bald","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Olgahospital, Klinikum Stuttgart, Stuttgart 70174, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Fl\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Department of BioMedical Research, Pediatric Endocrinology, Diabetology and Metabolism, Bern University Hospital Inselspital and University of Bern, Bern 3010, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Schulz","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, AKK Altonaer Kinderkrankenhaus GmbH, Hamburg 22763, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egbert","family":"Voss","sequence":"additional","affiliation":[{"name":"Cnopfsche Kinderklinik, N\u00fcrnberg 90419, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-5575","authenticated-orcid":false,"given":"Lajos","family":"Mark\u00f3","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin 13353, Germany"},{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Berlin 13125, Germany"},{"name":"Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin 10178, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Linz","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU), Erlangen 91054, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-5644","authenticated-orcid":false,"given":"Dominik N","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin 13353, Germany"},{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Berlin 13125, Germany"},{"name":"Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin 10178, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Kuehne","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"},{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin 13353, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Litt","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D","family":"Cone","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, and Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI 48109-5624, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-176X","authenticated-orcid":false,"given":"Peter","family":"K\u00fchnen","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Institute for Experimental Pediatric Endocrinology, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-0452","authenticated-orcid":false,"given":"Marcus","family":"Kelm","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"},{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin 13353, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin 10178, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"9945","key":"2021120108561986400_CIT0001","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"issue":"9492","key":"2021120108561986400_CIT0002","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet."},{"issue":"1","key":"2021120108561986400_CIT0003","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2012.113905","article-title":"Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis","volume":"309","author":"Flegal","year":"2013","journal-title":"JAMA."},{"issue":"6","key":"2021120108561986400_CIT0004","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/S2468-2667(17)30074-9","article-title":"Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe","volume":"2","author":"Kivimaki","year":"2017","journal-title":"Lancet Public Health"},{"key":"2021120108561986400_CIT0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.metabol.2018.10.007","article-title":"Genetics and epigenetics in obesity","volume":"92","author":"Rohde","year":"2019","journal-title":"Metabolism."},{"issue":"4","key":"2021120108561986400_CIT0006","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1023\/A:1025635913927","article-title":"Genetic and environmental factors in relative body weight and human adiposity","volume":"27","author":"Maes","year":"1997","journal-title":"Behav Genet."},{"issue":"12","key":"2021120108561986400_CIT0007","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122036","article-title":"Tissue sodium content and arterial hypertension in obese adolescents","volume":"8","author":"Roth","year":"2019","journal-title":"J Clin Med"},{"issue":"3","key":"2021120108561986400_CIT0008","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ng0398-213","article-title":"A leptin missense mutation associated with hypogonadism and morbid obesity","volume":"18","author":"Strobel","year":"1998","journal-title":"Nat Genet."},{"issue":"6674","key":"2021120108561986400_CIT0009","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/32911","article-title":"A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction","volume":"392","author":"Clement","year":"1998","journal-title":"Nature"},{"issue":"3","key":"2021120108561986400_CIT0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng0797-303","article-title":"Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene","volume":"16","author":"Jackson","year":"1997","journal-title":"Nat Genet."},{"issue":"2","key":"2021120108561986400_CIT0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/509","article-title":"Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans","volume":"19","author":"Krude","year":"1998","journal-title":"Nat Genet."},{"issue":"9","key":"2021120108561986400_CIT0012","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.2337\/db08-0153","article-title":"Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees","volume":"57","author":"Stutzmann","year":"2008","journal-title":"Diabetes."},{"issue":"1","key":"2021120108561986400_CIT0013","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMoa0803085","article-title":"Modulation of blood pressure by central melanocortinergic pathways","volume":"360","author":"Greenfield","year":"2009","journal-title":"N Engl J Med"},{"issue":"4","key":"2021120108561986400_CIT0014","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1210\/jc.2009-2297","article-title":"Sympathetic function in human carriers of melanocortin-4 receptor gene mutations","volume":"95","author":"Sayk","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"key":"2021120108561986400_CIT0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28118","article-title":"Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy","volume":"6","author":"Litt","year":"2017","journal-title":"Elife"},{"issue":"4","key":"2021120108561986400_CIT0016","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCULATIONAHA.111.062430","article-title":"Dietary sodium intake in heart failure","volume":"126","author":"Gupta","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"2021120108561986400_CIT0017","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCHEARTFAILURE.114.001700","article-title":"Comparing sodium intake strategies in heart failure: rationale and design of the prevent adverse outcomes in heart failure by limiting sodium (PROHIBIT) study","volume":"8","author":"Butler","year":"2015","journal-title":"Circ Heart Fail."},{"issue":"4","key":"2021120108561986400_CIT0018","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ejcn.2010.8","article-title":"Body mass index percentiles for children and adolescents in Germany based on a nationally representative sample (KiGGS 2003-2006)","volume":"64","author":"Rosario","year":"2010","journal-title":"Eur J Clin Nutr."},{"issue":"5","key":"2021120108561986400_CIT0019","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jmri.22521","article-title":"Reference values for atrial size and function in children and young adults by cardiac MR: a study of the German competence network congenital heart defects","volume":"33","author":"Sarikouch","year":"2011","journal-title":"J Magn Reson Imaging."},{"issue":"1","key":"2021120108561986400_CIT0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/HYPERTENSIONAHA.111.183517","article-title":"(23)Na magnetic resonance imaging of tissue sodium","volume":"59","author":"Kopp","year":"2012","journal-title":"Hypertension"},{"key":"2021120108561986400_CIT0021","volume-title":"10.5281\/zenodo.4733918. Data repository supplement","author":"Puder","year":"2021"},{"issue":"3","key":"2021120108561986400_CIT0022","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/HYPERTENSIONAHA.111.00566","article-title":"23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients","volume":"61","author":"Kopp","year":"2013","journal-title":"Hypertension."},{"issue":"2","key":"2021120108561986400_CIT0023","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ki.2014.269","article-title":"Magnetic resonance-determined sodium removal from tissue stores in hemodialysis patients","volume":"87","author":"Dahlmann","year":"2015","journal-title":"Kidney Int"},{"issue":"6","key":"2021120108561986400_CIT0024","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1681\/ASN.2016060662","article-title":"Skin sodium concentration correlates with left ventricular hypertrophy in CKD","volume":"28","author":"Schneider","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"2021120108561986400_CIT0025","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.acra.2017.03.012","article-title":"3 Tesla (23)Na magnetic resonance imaging during acute kidney injury","volume":"24","author":"Hammon","year":"2017","journal-title":"Acad Radiol"},{"issue":"10","key":"2021120108561986400_CIT0026","doi-asserted-by":"crossref","first-page":"e0141336","DOI":"10.1371\/journal.pone.0141336","article-title":"23Na Magnetic resonance imaging of the lower leg of acute heart failure patients during diuretic treatment","volume":"10","author":"Hammon","year":"2015","journal-title":"PLoS One."},{"key":"2021120108561986400_CIT0027","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mri.2016.10.023","article-title":"Sex differences in sodium deposition in human muscle and skin","volume":"36","author":"Wang","year":"2017","journal-title":"Magn Reson Imaging."},{"issue":"1","key":"2021120108561986400_CIT0028","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMoa0803085","article-title":"Modulation of blood pressure by central melanocortinergic pathways","volume":"360","author":"Greenfield","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"2021120108561986400_CIT0029","first-page":"25","article-title":"Changes in cardiac muscle mass and function in hemodialysis patients during growth hormone treatment","volume":"53","author":"Jensen","year":"2000","journal-title":"Clin Nephrol."},{"issue":"1","key":"2021120108561986400_CIT0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jacbts.2020.11.007","article-title":"Restoration of cardiac function after myocardial infarction by long-term activation of the CNS leptin-melanocortin system","volume":"6","author":"Gava","year":"2021","journal-title":"JACC Basic Transl Sci."},{"issue":"5","key":"2021120108561986400_CIT0031","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.2337\/db10-1106","article-title":"Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob\/ob mice","volume":"60","author":"Sloan","year":"2011","journal-title":"Diabetes."},{"issue":"1","key":"2021120108561986400_CIT0032","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvq288","article-title":"Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice","volume":"89","author":"McGaffin","year":"2011","journal-title":"Cardiovasc Res."},{"issue":"7767","key":"2021120108561986400_CIT0033","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-019-1414-x","article-title":"Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects","volume":"572","author":"de Soysa","year":"2019","journal-title":"Nature."},{"issue":"2","key":"2021120108561986400_CIT0034","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.molmed.2018.12.002","article-title":"Melanocortin-4 receptor signalling: importance for weight regulation and obesity treatment","volume":"25","author":"K\u00fchnen","year":"2019","journal-title":"Trends Mol Med."},{"issue":"7","key":"2021120108561986400_CIT0035","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1056\/NEJMoa1304127","article-title":"Global sodium consumption and death from cardiovascular causes","volume":"371","author":"Mozaffarian","year":"2014","journal-title":"N Engl J Med."},{"issue":"9","key":"2021120108561986400_CIT0036","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ijo.2010.273","article-title":"Oedema in obesity; role of structural lymphatic abnormalities","volume":"35","author":"Vasileiou","year":"2011","journal-title":"Int J Obes (Lond)."},{"issue":"1","key":"2021120108561986400_CIT0037","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mcna.2016.08.009","article-title":"The renin angiotensin aldosterone system in obesity and hypertension: roles in the cardiorenal metabolic syndrome","volume":"101","author":"Cabandugama","year":"2017","journal-title":"Med Clin North Am."},{"issue":"2","key":"2021120108561986400_CIT0038","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/jama.1991.03470020057032","article-title":"The impact of obesity on left ventricular mass and geometry. The Framingham heart study","volume":"266","author":"Lauer","year":"1991","journal-title":"JAMA."},{"issue":"1","key":"2021120108561986400_CIT0039","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0735-1097(92)90063-S","article-title":"Separate and joint influences of obesity and mild hypertension on left ventricular mass and geometry: the Framingham Heart Study","volume":"19","author":"Lauer","year":"1992","journal-title":"J Am Coll Cardiol."},{"issue":"4","key":"2021120108561986400_CIT0040","first-page":"193","article-title":"Ventricular mass in hypertensive and normotensive obese subjects","volume":"18","author":"de la Maza","year":"1994","journal-title":"Int J Obes"},{"issue":"21","key":"2021120108561986400_CIT0041","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jacc.2008.12.068","article-title":"Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss","volume":"53","author":"Lavie","year":"2009","journal-title":"J Am Coll Cardiol."},{"key":"2021120108561986400_CIT0042","doi-asserted-by":"crossref","first-page":"626s","DOI":"10.1093\/ajcn\/65.2.626S","article-title":"The INTERSALT Study: background, methods, findings, and implications","volume":"65","author":"Stamler","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2021120108561986400_CIT0043","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/01.CIR.78.4.951","article-title":"Dietary salt intake. A determinant of cardiac involvement in essential hypertension","volume":"78","author":"Schmieder","year":"1988","journal-title":"Circulation."},{"issue":"21","key":"2021120108561986400_CIT0044","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.282.21.2027","article-title":"Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults","volume":"282","author":"He","year":"1999","journal-title":"Jama."},{"issue":"3","key":"2021120108561986400_CIT0045","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist","volume":"375","author":"K\u00fchnen","year":"2016","journal-title":"N Engl J Med."},{"issue":"12","key":"2021120108561986400_CIT0046","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S2213-8587(20)30364-8","article-title":"Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials","volume":"8","author":"Cl\u00e9ment","year":"2020","journal-title":"Lancet Diabetes Endocrinol."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab368\/38847140\/dgab368.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/9\/2606\/41379209\/dgab368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/9\/2606\/41379209\/dgab368.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T14:00:25Z","timestamp":1638367225000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/9\/2606\/6283725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5,24]]},"published-print":{"date-parts":[[2021,8,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab368","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,5,24]]}}}