{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:49:16Z","timestamp":1791996556032,"version":"4.4.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Diabetic ketoacidosis (DKA) is a serious endocrine emergency, associated with morbidity and mortality. Readmissions play a significant but sometimes preventable role in healthcare cost burden on the US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to describe rates and characteristics of nonelective 30-day readmission among adult patients with diabetes mellitus type 1 (T1DM) hospitalized for DKA and also identify predictors of readmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study analyzed the 2018 Nationwide Readmission Database. DKA hospitalizations in patients with T1DM were classified using International Classification of Diseases, Tenth Revision, Clinical Modification codes. We utilized chi-squared tests to compare baseline characteristics between readmissions and index hospitalizations. Multivariable Cox regression was employed to identify independent predictors of readmission. Following this, we developed a 30-day readmission risk scoring system based on independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 30-day all-cause readmission rate for DKA was 19.4%. A majority of patients (64.8%) had DKA as the principal diagnosis on readmission. Readmitted patients had a significantly higher mean age (35.3 vs 34.9 years, P\u2005=\u2005.018) and a higher proportion of females (52.8 vs 49.6%, P\u2005&amp;lt;\u2005.001) than the index admission. Readmission following DKA was associated with higher odds of inpatient mortality (0.69 vs 0.24%, OR 2.84, 95% CI 1.99-4.06, P\u2005&amp;lt;\u2005.001). Independent predictors of 30-day all-cause readmission included female sex, index hospitalizations with Charlson Comorbidity Index (CCI) score of 3 or greater, and being discharged against medical advice (AMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The readmission rate for DKA in T1DM patients is high, and most patients have DKA as the principal diagnosis on readmission. A CCI equal to or greater than 3, hypertension, female sex, and being discharged AMA were significant predictors of readmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab372","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T18:01:17Z","timestamp":1622138477000},"page":"2592-2599","source":"Crossref","is-referenced-by-count":37,"title":["Rate and Predictors of 30-day Readmission Following Diabetic Ketoacidosis in Type 1 Diabetes Mellitus: A US Analysis"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-4581","authenticated-orcid":false,"given":"Hafeez","family":"Shaka","sequence":"first","affiliation":[{"name":"John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Aguilera","sequence":"additional","affiliation":[{"name":"John H. 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Charles","family":"Muojieje","sequence":"additional","affiliation":[{"name":"Mountain View regional medical center, Las Cruces, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-8572","authenticated-orcid":false,"given":"Asim","family":"Kichloo","sequence":"additional","affiliation":[{"name":"Central Michigan University, College of Medicine, Saginaw, MI, USA"},{"name":"Samaritan Medical Center, Watertown, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"2021120108561340200_CIT0001","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fendo.2017.00106","article-title":"Review of evidence for adult diabetic ketoacidosis management protocols","volume":"8","author":"Tran","year":"2017","journal-title":"Front Endocrinol."},{"issue":"6","key":"2021120108561340200_CIT0002","first-page":"OC01","article-title":"Clinical profile 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