{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:55:47Z","timestamp":1790024147451,"version":"4.0.1"},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a postvaccination phenomenon that occurs after exposure to adjuvants in vaccines that increase the immune responses. There are very limited data regarding ASIA syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This work aims to report cases of subacute thyroiditis related to the SARS-CoV-2 vaccine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We describe the clinical, laboratory, and imaging features of 3 cases of subacute thyroiditis after inactivated SARS-CoV-2 vaccine (CoronaVac\u00ae). Three female healthcare workers have applied to our clinic with anterior neck pain and fatigue 4 to 7 days after SARS-CoV-2 vaccination. Two of them were in the breastfeeding period. They were negative for thyroid antibodies, and there was no previous history of thyroid disease, upper respiratory tract infection, or COVID-19. Laboratory test results and imaging findings were consistent with subacute thyroiditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SARS-CoV-2 vaccination can lead to subacute thyroiditis as a phenomenon of ASIA syndrome. Subacute thyroiditis may develop within a few days after the SARS-CoV-2 vaccination. Being in the postpartum period may be a facilitating factor for the development of ASIA syndrome after the SARS-CoV-2 vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first report of subacute thyroiditis as a phenomenon of ASIA syndrome after inactivated COVID-19 vaccination. Clinicians should be aware that subacute thyroiditis may develop as a manifestation of ASIA syndrome after the inactive SARS-CoV-2 vaccine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab373","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T22:01:34Z","timestamp":1622152894000},"page":"2600-2605","source":"Crossref","is-referenced-by-count":157,"title":["Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome"],"prefix":"10.1210","volume":"106","author":[{"given":"Bur\u00e7in G\u00f6n\u00fcl","family":"\u0130remli","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman Nahit","family":"\u015eendur","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-1396","authenticated-orcid":false,"given":"U\u011fur","family":"\u00dcnl\u00fct\u00fcrk","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"7","key":"2021120108561088400_CIT0001","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1055\/a-1172-1352","article-title":"Endocrine conditions and COVID-19","volume":"52","author":"Shekhar","year":"2020","journal-title":"Horm Metab Res."},{"issue":"5","key":"2021120108561088400_CIT0002","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4103\/ijem.IJEM_440_20","article-title":"Endocrine involvement in COVID-19: mechanisms, clinical features, and implications for care","volume":"24","author":"Garg","year":"2020","journal-title":"Indian J Endocrinol Metab."},{"issue":"2","key":"2021120108561088400_CIT0003","doi-asserted-by":"crossref","first-page":"e926","DOI":"10.1210\/clinem\/dgaa813","article-title":"Thyroid dysfunction in relation to immune profile, disease status, and outcome in 191 patients with COVID-19","volume":"106","author":"Lui","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021120108561088400_CIT0004","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s40618-020-01366-7","article-title":"SARS-COV-2 as a trigger for autoimmune disease: report of two cases of Graves\u2019 disease after COVID-19","volume":"43","author":"Mateu-Salat","year":"2020","journal-title":"J Endocrinol Invest."},{"issue":"10","key":"2021120108561088400_CIT0005","doi-asserted-by":"crossref","first-page":"e3742","DOI":"10.1210\/clinem\/dgaa537","article-title":"Is subacute thyroiditis an underestimated manifestation of SARS-CoV-2 infection? 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