{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:18:07Z","timestamp":1792448287170,"version":"4.5.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001878"],"award-info":[{"award-number":["UL1TR001878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2-TR001879"],"award-info":[{"award-number":["KL2-TR001879"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA246586-01"],"award-info":[{"award-number":["R01 CA246586-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Pheochromocytomas and paragangliomas (PCC\/PGL) are neuroendocrine tumors with discrete catecholamine profiles that cause incompletely understood metabolic and physiologic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective was to evaluate relationships between plasma catecholamines, body weight, and hemoglobin A1c (HbA1c). We hypothesized that individual catecholamines would correlate negatively with weight and glucose control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed (1999-2020). Wilcoxon rank-sum tests compared nonparametric, continuous variables; mixed-effect linear modeling (MEM) evaluated relationships between catecholamines and weight or HbA1c. The median study duration was 54.2 months [interquartile range (IQR) 19.0-95.1].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary academic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>360 patients were identified prospectively by referral to our center for management or surveillance of PCC\/PGL. The median age was 59 years (IQR 45-67) and 56.4% (n\u2005=\u2005203) were female.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The primary and secondary outcomes were weight and HbA1c, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On multivariable MEM, norepinephrine (P\u2005&amp;lt;\u20050.0005) negatively correlated with weight when all catecholamines and their derivatives were tried in the model, and normetanephrine (P\u2005&amp;lt;\u20050.0005) correlated when only metanephrines were included. In the surgical cohort (n\u2005=\u2005272), normetanephrine decreased postoperatively and was inversely associated with weight (P\u2005&amp;lt;\u20050.0005). Elevated norepinephrine or normetanephrine at the study termination, indicative of metastatic and\/or recurrent disease (MRD), correlated with weight loss. Norepinephrine and normetanephrine (P\u2005&amp;lt;\u20050.0005) directly correlated with HbA1c.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma norepinephrine and its metabolite directly correlate with HbA1c and inversely correlate with weight in PCC\/PGL. After resection, declining normetanephrine levels correlate with improving HbA1c despite an increase in patient body weight. Persistently elevated catecholamines and decreasing weight are observed in MRD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab401","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T15:03:50Z","timestamp":1622905430000},"page":"e4028-e4038","source":"Crossref","is-referenced-by-count":29,"title":["Correlation Between Plasma Catecholamines, Weight, and Diabetes in Pheochromocytoma and Paraganglioma"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3261-1557","authenticated-orcid":false,"given":"Lauren N","family":"Krumeich","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania, Department of Surgery, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-3895","authenticated-orcid":false,"given":"Andrew J","family":"Cucchiara","sequence":"additional","affiliation":[{"name":"Hospital of the 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