{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:30:34Z","timestamp":1769945434911,"version":"3.49.0"},"reference-count":52,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073554"],"award-info":[{"award-number":["82073554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930124"],"award-info":[{"award-number":["81930124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2021GCRC076"],"award-info":[{"award-number":["2021GCRC076"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the association of circulating 25-hydroxyvitamin D [25(OH)D] levels with mortality among adults with prediabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study included 15,195 adults with prediabetes (aged \u226520 years) from the National Health and Nutrition Examination Survey (NHANES) III and NHANES 2001-2014. Mortality from all causes, cardiovascular disease (CVD), and cancer was linked to National Death Index mortality data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median (interquartile range) concentration of serum 25(OH)D was 60.5 (45.3, 77.4) nmol\/L, and only 23.1% had sufficient vitamin D (\u226575 nmol\/L). Elevated serum 25(OH)D concentrations were significantly associated with lower levels of insulin, homeostasis model assessment of insulin resistance, triglyceride, and C-reactive protein, and higher levels of high-density lipoprotein at baseline (all Ptrend\u2005&amp;lt;\u20050.05). During a median follow up of 10.7 years, 3765 deaths (including 1080 CVD deaths and 863 cancer deaths) were identified. Compared with participants with 25(OH)D &amp;lt;30 nmol\/L, the multivariate-adjusted hazard ratios and 95% confidence intervals for participants with 25(OH)D\u2005\u2265\u200575 nmol\/L were 0.66 (0.53, 0.82) for all-cause mortality (Ptrend\u2005&amp;lt;\u20050.001), 0.66 (0.48, 0.89) for CVD mortality (Ptrend\u2005=\u20050.001), and 0.82 (0.49, 1.35) for cancer mortality (Ptrend\u2005=\u20050.32). For per-unit increment in ln-transformed 25(OH)D, there was a 27% lower risk of all-cause mortality and a 34% lower risk of CVD mortality (both P\u2005&amp;lt;\u20050.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggested that higher serum 25(OH)D concentrations were associated with lower all-cause and CVD mortality among individuals with prediabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab402","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T19:03:54Z","timestamp":1622919834000},"page":"e4039-e4048","source":"Crossref","is-referenced-by-count":22,"title":["Association Between Serum 25-hydroxyvitamin D Concentrations and Mortality Among Adults With Prediabetes"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-5712","authenticated-orcid":false,"given":"Qi","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Health Toxicology, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-7945","authenticated-orcid":false,"given":"An","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-3016","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"2021110611592855200_CIT0001","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.2337\/dc20-S002","article-title":"Classification and diagnosis of diabetes: standards of medical care in diabetes-2020","volume":"43","author":"American Diabetes Association.","year":"2020","journal-title":"Diabetes Care."},{"key":"2021110611592855200_CIT0002","doi-asserted-by":"crossref","first-page":"m2297","DOI":"10.1136\/bmj.m2297","article-title":"Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis","volume":"370","author":"Cai","year":"2020","journal-title":"BMJ."},{"issue":"9833","key":"2021110611592855200_CIT0003","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tab\u00e1k","year":"2012","journal-title":"Lancet."},{"issue":"9","key":"2021110611592855200_CIT0004","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00125-010-1796-7","article-title":"Diabetes, prediabetes and cancer mortality","volume":"53","author":"Zhou","year":"2010","journal-title":"Diabetologia."},{"issue":"9","key":"2021110611592855200_CIT0005","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1056\/NEJMoa0908359","article-title":"Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults","volume":"362","author":"Selvin","year":"2010","journal-title":"N Engl J Med."},{"issue":"13","key":"2021110611592855200_CIT0006","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jacc.2009.10.060","article-title":"Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence","volume":"55","author":"Ford","year":"2010","journal-title":"J Am Coll Cardiol."},{"issue":"24","key":"2021110611592855200_CIT0007","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1001\/jama.2019.19365","article-title":"Prevalence of diabetes by race and ethnicity in the United States, 2011-2016","volume":"322","author":"Cheng","year":"2019","journal-title":"JAMA."},{"issue":"6 Suppl","key":"2021110611592855200_CIT0008","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr."},{"issue":"4","key":"2021110611592855200_CIT0009","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr Rev."},{"key":"2021110611592855200_CIT0010","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jaut.2017.07.007","article-title":"Modulation of inflammatory and immune responses by vitamin D","volume":"85","author":"Colotta","year":"2017","journal-title":"J Autoimmun."},{"issue":"1","key":"2021110611592855200_CIT0011","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N Engl J Med."},{"issue":"6","key":"2021110611592855200_CIT0012","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/jamacardio.2017.0175","article-title":"Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial","volume":"2","author":"Scragg","year":"2017","journal-title":"JAMA Cardiol."},{"issue":"5","key":"2021110611592855200_CIT0013","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2337\/dc10-1203","article-title":"Serum 25-hydroxyvitamin D levels and prediabetes among subjects free of diabetes","volume":"34","author":"Shankar","year":"2011","journal-title":"Diabetes Care."},{"key":"2021110611592855200_CIT0014","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cca.2017.02.022","article-title":"Association of serum 25-hydroxyvitamin D3 with adipokines and inflammatory marker in persons with prediabetes mellitus","volume":"468","author":"Zhang","year":"2017","journal-title":"Clin Chim Acta."},{"issue":"2","key":"2021110611592855200_CIT0015","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.atherosclerosis.2015.09.038","article-title":"Low circulating vitamin D levels are associated with increased arterial stiffness in prediabetic subjects identified according to HbA1c","volume":"243","author":"Zagami","year":"2015","journal-title":"Atherosclerosis."},{"issue":"4","key":"2021110611592855200_CIT0016","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3945\/jn.114.209171","article-title":"Low circulating 25-hydroxyvitamin D concentrations are associated with defects in insulin action and insulin secretion in persons with prediabetes","volume":"145","author":"Abbasi","year":"2015","journal-title":"J Nutr."},{"key":"2021110611592855200_CIT0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2018.12.008","article-title":"Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized clinical trial","volume":"148","author":"Niroomand","year":"2019","journal-title":"Diabetes Res Clin Pract."},{"issue":"7","key":"2021110611592855200_CIT0018","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/dc19-1708","article-title":"Effects of vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: a systematic review and meta-analysis","volume":"43","author":"Zhang","year":"2020","journal-title":"Diabetes Care."},{"key":"2021110611592855200_CIT0019","author":"Centers for Disease Control and Prevention."},{"key":"2021110611592855200_CIT0020","author":"Lu","year":"2021"},{"key":"2021110611592855200_CIT0021","author":"Centers for Disease Control and Prevention."},{"issue":"7","key":"2021110611592855200_CIT0022","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"issue":"9","key":"2021110611592855200_CIT0023","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med."},{"issue":"4","key":"2021110611592855200_CIT0024","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3945\/ajcn.116.140392","article-title":"Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies","volume":"105","author":"Zhang","year":"2017","journal-title":"Am J Clin Nutr."},{"key":"2021110611592855200_CIT0025","doi-asserted-by":"crossref","first-page":"g3656","DOI":"10.1136\/bmj.g3656","article-title":"Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States","volume":"348","author":"Sch\u00f6ttker","year":"2014","journal-title":"BMJ."},{"issue":"6","key":"2021110611592855200_CIT0026","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.mayocp.2018.03.006","article-title":"Serum 25-hydroxyvitamin D values and risk of all-cause and cause-specific mortality: a population-based cohort study","volume":"93","author":"Dudenkov","year":"2018","journal-title":"Mayo Clin Proc."},{"issue":"6","key":"2021110611592855200_CIT0027","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.mayocp.2018.04.014","article-title":"The death D-fying vitamin","volume":"93","author":"Holick","year":"2018","journal-title":"Mayo Clin Proc."},{"key":"2021110611592855200_CIT0028","doi-asserted-by":"crossref","first-page":"l4673","DOI":"10.1136\/bmj.l4673","article-title":"Association between vitamin D supplementation and mortality: systematic review and meta-analysis","volume":"366","author":"Zhang","year":"2019","journal-title":"BMJ."},{"issue":"8","key":"2021110611592855200_CIT0029","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jamacardio.2019.1870","article-title":"Vitamin D supplementation and cardiovascular disease risks in more than 83\u202f000 individuals in 21 randomized clinical trials: a meta-analysis","volume":"4","author":"Barbarawi","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"11","key":"2021110611592855200_CIT0030","doi-asserted-by":"crossref","first-page":"e2025850","DOI":"10.1001\/jamanetworkopen.2020.25850","article-title":"Effect of vitamin D3 supplements on development of advanced cancer: a secondary analysis of the VITAL randomized clinical trial","volume":"3","author":"Chandler","year":"2020","journal-title":"JAMA Netw Open."},{"issue":"5","key":"2021110611592855200_CIT0031","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3390\/nu10050561","article-title":"Emerging evidence of thresholds for beneficial effects from vitamin D supplementation","volume":"10","author":"Scragg","year":"2018","journal-title":"Nutrients."},{"issue":"8","key":"2021110611592855200_CIT0032","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1210\/clinem\/dgaa335","article-title":"Effect of vitamin D supplementation on the incidence of diabetes mellitus","volume":"105","author":"Barbarawi","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2021110611592855200_CIT0033","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2337\/dc14-0218","article-title":"No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes","volume":"37","author":"Sollid","year":"2014","journal-title":"Diabetes Care."},{"issue":"1","key":"2021110611592855200_CIT0034","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3945\/ajcn.113.069260","article-title":"Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-Western immigrants in the Netherlands: a randomized placebo-controlled trial","volume":"100","author":"Oosterwerff","year":"2014","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"2021110611592855200_CIT0035","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.diabres.2013.12.044","article-title":"Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India","volume":"103","author":"Dutta","year":"2014","journal-title":"Diabetes Res Clin Pract."},{"issue":"2","key":"2021110611592855200_CIT0036","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2337\/dc12-1204","article-title":"High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D","volume":"36","author":"Davidson","year":"2013","journal-title":"Diabetes Care."},{"issue":"2","key":"2021110611592855200_CIT0037","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3945\/ajcn.111.011684","article-title":"Effects of vitamin D and calcium supplementation on pancreatic \u03b2 cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial","volume":"94","author":"Mitri","year":"2011","journal-title":"Am J Clin Nutr."},{"issue":"6","key":"2021110611592855200_CIT0038","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJMoa1900906","article-title":"Vitamin D supplementation and prevention of type 2 diabetes","volume":"381","author":"Pittas","year":"2019","journal-title":"N Engl J Med."},{"issue":"12","key":"2021110611592855200_CIT0039","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.2337\/dc20-1765","article-title":"Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study","volume":"43","author":"Dawson-Hughes","year":"2020","journal-title":"Diabetes Care."},{"key":"2021110611592855200_CIT0040","article-title":"Vitamin D: production, metabolism, and mechanisms of action","volume-title":"Endotext [internet].","author":"Bikle","year":"2017"},{"issue":"6","key":"2021110611592855200_CIT0041","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/HYPERTENSIONAHA.114.03971","article-title":"Elimination of vitamin D receptor in vascular endothelial cells alters vascular function","volume":"64","author":"Ni","year":"2014","journal-title":"Hypertension."},{"issue":"2","key":"2021110611592855200_CIT0042","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J Clin Invest."},{"issue":"4458","key":"2021110611592855200_CIT0043","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.6250216","article-title":"Vitamin D deficiency inhibits pancreatic secretion of insulin","volume":"209","author":"Norman","year":"1980","journal-title":"Science."},{"issue":"1","key":"2021110611592855200_CIT0044","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/endo-119-1-84","article-title":"Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo","volume":"119","author":"Cade","year":"1986","journal-title":"Endocrinology."},{"issue":"3","key":"2021110611592855200_CIT0045","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1096\/fj.02-0424fje","article-title":"Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor","volume":"17","author":"Zeitz","year":"2003","journal-title":"Faseb J."},{"issue":"11","key":"2021110611592855200_CIT0046","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.2337\/db11-0465","article-title":"Prospective associations of vitamin D with \u03b2-cell function and glycemia: the PROspective metabolism and ISlet cell evaluation (PROMISE) cohort study","volume":"60","author":"Kayaniyil","year":"2011","journal-title":"Diabetes."},{"issue":"4","key":"2021110611592855200_CIT0047","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1017\/S0007114509992017","article-title":"Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial","volume":"103","author":"von Hurst","year":"2010","journal-title":"Br J Nutr."},{"issue":"6","key":"2021110611592855200_CIT0048","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2337\/dc09-2321","article-title":"Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes","volume":"33","author":"Kayaniyil","year":"2010","journal-title":"Diabetes Care."},{"issue":"5","key":"2021110611592855200_CIT0049","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/ajcn\/79.5.820","article-title":"Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction","volume":"79","author":"Chiu","year":"2004","journal-title":"Am J Clin Nutr."},{"issue":"8","key":"2021110611592855200_CIT0050","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/aje\/kwq005","article-title":"Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study","volume":"171","author":"Jorde","year":"2010","journal-title":"Am J Epidemiol."},{"issue":"1","key":"2021110611592855200_CIT0051","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1210\/jc.2016-2930","article-title":"Effects of genetic and nongenetic factors on total and bioavailable 25(OH)D responses to vitamin D supplementation","volume":"102","author":"Yao","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"issue":"21","key":"2021110611592855200_CIT0052","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa1306357","article-title":"Vitamin D-binding protein and vitamin D status of black Americans and white Americans","volume":"369","author":"Powe","year":"2013","journal-title":"N Engl J Med."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab402\/38829164\/dgab402.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e4039\/41098139\/dgab402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e4039\/41098139\/dgab402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T12:01:10Z","timestamp":1636200070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/10\/e4039\/6294005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,5]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,6,5]]},"published-print":{"date-parts":[[2021,9,27]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab402","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,6,5]]}}}