{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:56:52Z","timestamp":1781060212729,"version":"3.54.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","award":["CB16\/10\/00245"],"award-info":[{"award-number":["CB16\/10\/00245"]}],"id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","award":["CB16\/10\/00501"],"award-info":[{"award-number":["CB16\/10\/00501"]}],"id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Formaci\u00f3n en Investigaci\u00f3n en Salud","award":["PI19\/00033"],"award-info":[{"award-number":["PI19\/00033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aims to elucidate the effect of 25(OH)D3 (calcifediol) treatment on COVID-19\u2013related outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This observational cohort study was conducted from March to May 2020, among patients admitted to COVID-19 wards of Hospital del Mar, Barcelona, Spain. A total of 930 patients with COVID-19 were included; 92 were excluded because of previous calcifediol intake. Of the remaining 838, a total of 447 received calcifediol (532 \u03bcg on day 1 plus 266 \u03bcg on days 3, 7, 15, and 30), whereas 391 were not treated at the time of hospital admission (intention-to-treat). Of the latter, 53 patients were treated later during ICU admission and were allocated in the treated group in a second analysis. In healthy individuals, calcifediol is about 3.2-fold more potent on a weight basis than cholecalciferol. Main outcome measures were ICU admission and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ICU assistance was required by 102 (12.2%) participants. Out of 447 patients treated with calcifediol at admission, 20 (4.5%) required the ICU, compared to 82 (21%) out of 391 nontreated (P\u2005&amp;lt;\u2005.001). Logistic regression of calcifediol treatment on ICU admission, adjusted by age, sex, linearized 25-hydroxyvitamin D levels at baseline, and comorbidities showed that treated patients had a reduced risk of requiring the ICU (odds ratio [OR] 0.13; 95% CI 0.07-0.23). Overall mortality was 10%. In the intention-to-treat analysis, 21 (4.7%) out of 447 patients treated with calcifediol at admission died compared to 62 patients (15.9%) out of 391 nontreated (P\u2005=\u2005.001). Adjusted results showed a reduced mortality risk with an OR of 0.21 (95% CI, 0.10-0.43). In the second analysis, the obtained OR was 0.52 (95% CI, 0.27-0.99).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients hospitalized with COVID-19, calcifediol treatment significantly reduced ICU admission and mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab405","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T14:51:41Z","timestamp":1623077501000},"page":"e4017-e4027","source":"Crossref","is-referenced-by-count":78,"title":["Calcifediol Treatment and COVID-19\u2013Related Outcomes"],"prefix":"10.1210","volume":"106","author":[{"given":"Xavier","family":"Nogues","sequence":"first","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"},{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ovejero","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"},{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pineda-Moncus\u00ed","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-3763","authenticated-orcid":false,"given":"Roger","family":"Bouillon","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Herestraat, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Arenas","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar\u2013IMIM, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar\u2013IMIM, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ribes","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Guerri-Fernandez","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"},{"name":"Department of Infectious Diseases, Hospital del Mar\u2013IMIM, Barcelona 08003,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Villar-Garcia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital del Mar\u2013IMIM, Barcelona 08003,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abora","family":"Rial","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Gimenez-Argente","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lourdes","family":"Cos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Rodriguez-Morera","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Campodarve","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital del Mar, Universitat Aut\u00f2noma de Barcelona, Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Quesada-Gomez","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Fundaci\u00f3n Progreso y Salud, CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Hospital Universitario Reina Sof\u00eda, Universidad de C\u00f3rdoba, 14004, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-0147","authenticated-orcid":false,"given":"Natalia","family":"Garcia-Giralt","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"issue":"18","key":"2021110611591708600_CIT0001","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med."},{"issue":"4","key":"2021110611591708600_CIT0002","doi-asserted-by":"crossref","first-page":"e13868","DOI":"10.1111\/ijcp.13868","article-title":"Novel coronavirus disease (COVID-19) update on epidemiology, pathogenicity, clinical course and treatments","volume":"75","author":"Boban","year":"2021","journal-title":"Int J Clin Pract."},{"issue":"47","key":"2021110611591708600_CIT0003","doi-asserted-by":"crossref","first-page":"2000548","DOI":"10.2807\/1560-7917.ES.2020.25.47.2000548","article-title":"Epidemiology and public health response in early phase of COVID-19 pandemic, Veneto Region, Italy, 21 February to 2 April 2020","volume":"25","author":"Russo","year":"2020","journal-title":"Euro Surveill"},{"issue":"19","key":"2021110611591708600_CIT0004","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","article-title":"Remdesivir for the treatment of Covid-19\u2014final report","volume":"383","author":"Beigel","year":"2020","journal-title":"N Engl J Med."},{"issue":"8","key":"2021110611591708600_CIT0005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19\u2014preliminary report","volume":"384","author":"RECOVERY Collaborative Group","year":"2021","journal-title":"N Engl J Med."},{"issue":"9","key":"2021110611591708600_CIT0006","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa2031994","article-title":"Baricitinib plus remdesivir for hospitalized adults with Covid-19","volume":"384","author":"Kalil","year":"2021","journal-title":"N Engl J Med."},{"issue":"2","key":"2021110611591708600_CIT0007","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJMc2033787","article-title":"Neutralizing antibody LY-CoV555 for outpatient Covid-19. Reply","volume":"384","author":"Nirula","year":"2021","journal-title":"N Engl J Med."},{"issue":"7","key":"2021110611591708600_CIT0008","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s40520-020-01570-8","article-title":"The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality","volume":"32","author":"Ilie","year":"2020","journal-title":"Aging Clin Exp Res."},{"issue":"9","key":"2021110611591708600_CIT0009","doi-asserted-by":"crossref","first-page":"e2019722","DOI":"10.1001\/jamanetworkopen.2020.19722","article-title":"Association of vitamin D status and other clinical characteristics with COVID-19 test results","volume":"3","author":"Meltzer","year":"2020","journal-title":"JAMA Netw Open."},{"issue":"1","key":"2021110611591708600_CIT0010","doi-asserted-by":"crossref","first-page":"e10405","DOI":"10.1002\/jbm4.10405","article-title":"Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory","volume":"5","author":"Bishop","year":"2021","journal-title":"JBMR Plus"},{"key":"2021110611591708600_CIT0011","doi-asserted-by":"crossref","DOI":"10.1111\/joim.12777","article-title":"Vitamin D and tuberculosis: where next?","author":"Brighenti","year":"2018","journal-title":"J Intern Med"},{"key":"2021110611591708600_CIT0012","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jsbmb.2018.11.013","article-title":"Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells","volume":"187","author":"Greiller","year":"2019","journal-title":"J Steroid Biochem Mol Biol."},{"key":"2021110611591708600_CIT0013","doi-asserted-by":"crossref","first-page":"i6583","DOI":"10.1136\/bmj.i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","journal-title":"BMJ."},{"issue":"1","key":"2021110611591708600_CIT0014","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13054-018-2185-8","article-title":"Vitamin D deficiency and supplementation in critical illness-the known knowns and known unknowns","volume":"22","author":"Nair","year":"2018","journal-title":"Crit Care."},{"issue":"4","key":"2021110611591708600_CIT0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/nu12040988","article-title":"Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths","volume":"12","author":"Grant","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"2021110611591708600_CIT0016","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S2213-8587(21)00051-6","article-title":"Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials","volume":"9","author":"Jolliffe","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2021110611591708600_CIT0017","author":"World Health Organization"},{"issue":"4","key":"2021110611591708600_CIT0018","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr Rev."},{"issue":"11","key":"2021110611591708600_CIT0019","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: an update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur J Clin Nutr."},{"key":"2021110611591708600_CIT0020","doi-asserted-by":"crossref","first-page":"105751","DOI":"10.1016\/j.jsbmb.2020.105751","article-title":"Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study","volume":"203","author":"Entrenas Castillo","year":"2020","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"11","key":"2021110611591708600_CIT0021","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/jama.2020.26848","article-title":"Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial","volume":"325","author":"Murai","year":"2021","journal-title":"JAMA."},{"key":"2021110611591708600_CIT0022","doi-asserted-by":"crossref","first-page":"105771","DOI":"10.1016\/j.jsbmb.2020.105771","article-title":"Vitamin D and survival in COVID-19 patients: a quasi-experimental study","volume":"204","author":"Annweiler","year":"2020","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"24","key":"2021110611591708600_CIT0023","doi-asserted-by":"crossref","first-page":"24522","DOI":"10.18632\/aging.202307","article-title":"Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests","volume":"12","author":"Cangiano","year":"2020","journal-title":"Aging (Albany NY)."},{"issue":"12","key":"2021110611591708600_CIT0024","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.3390\/nu12123799","article-title":"High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: a cross-sectional multi-centre observational study","volume":"12","author":"Ling","year":"2020","journal-title":"Nutrients"},{"issue":"8","key":"2021110611591708600_CIT0025","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00198-018-4520-y","article-title":"Is calcifediol better than cholecalciferol for vitamin D supplementation?","volume":"29","author":"Quesada-Gomez","year":"2018","journal-title":"Osteoporos Int."},{"key":"2021110611591708600_CIT0026","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2013.10.014","article-title":"Pharmacokinetics of oral vitamin D3 and calcifediol","volume":"59","author":"Jetter","year":"2014","journal-title":"Bone."},{"issue":"4","key":"2021110611591708600_CIT0027","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s40618-020-01370-x","article-title":"Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19","volume":"44","author":"Carpagnano","year":"2021","journal-title":"J Endocrinol Invest."},{"issue":"9","key":"2021110611591708600_CIT0028","doi-asserted-by":"crossref","first-page":"e0239799","DOI":"10.1371\/journal.pone.0239799","article-title":"Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng\/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection","volume":"15","author":"Maghbooli","year":"2020","journal-title":"PloS One."},{"issue":"9","key":"2021110611591708600_CIT0029","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3390\/nu12092757","article-title":"Vitamin D deficiency and outcome of COVID-19 patients","volume":"12","author":"Radujkovic","year":"2020","journal-title":"Nutrients"},{"key":"2021110611591708600_CIT0030","doi-asserted-by":"crossref","DOI":"10.1080\/07315724.2020.1826005","article-title":"Does serum vitamin D level affect COVID-19 infection and its severity?\u2014a case-control study","author":"Ye","year":"2020","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"2021110611591708600_CIT0031","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/cen.14310","article-title":"Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity","volume":"93","author":"Panagiotou","year":"2020","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2021110611591708600_CIT0032","doi-asserted-by":"crossref","DOI":"10.1136\/postgradmedj-2020-138712","article-title":"Vitamin D status and outcomes for hospitalised older patients with COVID-19","author":"Baktash","year":"2020","journal-title":"Postgrad Med J"},{"issue":"1","key":"2021110611591708600_CIT0033","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00394-020-02372-4","article-title":"Vitamin D and COVID-19 infection and mortality in UK Biobank","volume":"60","author":"Hastie","year":"2021","journal-title":"Eur J Nutr."},{"issue":"9","key":"2021110611591708600_CIT0034","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.3390\/nu12092775","article-title":"Impact of vitamin D deficiency on COVID-19\u2014a prospective analysis from the CovILD registry","volume":"12","author":"Pizzini","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"2021110611591708600_CIT0035","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir Med."},{"issue":"5","key":"2021110611591708600_CIT0036","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology","volume":"39","author":"Channappanavar","year":"2017","journal-title":"Semin Immunopathol."},{"issue":"5","key":"2021110611591708600_CIT0037","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.humimm.2009.01.016","article-title":"Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists","volume":"70","author":"Adorini","year":"2009","journal-title":"Hum Immunol."},{"issue":"13","key":"2021110611591708600_CIT0038","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1182\/blood-2005-03-1029","article-title":"1\u03b1,25-Dihydroxyvitamin D3 is a potent suppressor of interferon \u03b3-mediated macrophage activation","volume":"106","author":"Helming","year":"2005","journal-title":"Blood."},{"key":"2021110611591708600_CIT0039","doi-asserted-by":"crossref","first-page":"105719","DOI":"10.1016\/j.jsbmb.2020.105719","article-title":"Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: revised Ms SBMB 2020_166","volume":"202","author":"Quesada-Gomez","year":"2020","journal-title":"J Steroid Biochem Mol Biol."},{"key":"2021110611591708600_CIT0040","doi-asserted-by":"crossref","first-page":"m1198","DOI":"10.1136\/bmj.m1198","article-title":"Covid-19: risk factors for severe disease and death","volume":"368","author":"Jordan","year":"2020","journal-title":"BMJ."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab405\/39552930\/dgab405.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e4017\/41098012\/dgab405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e4017\/41098012\/dgab405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T12:00:52Z","timestamp":1636200052000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/10\/e4017\/6294179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,6,7]]},"published-print":{"date-parts":[[2021,9,27]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab405","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,6,7]]}}}