{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:37:40Z","timestamp":1780735060760,"version":"3.54.1"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["325768017"],"award-info":[{"award-number":["325768017"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271-TRR205"],"award-info":[{"award-number":["314061271-TRR205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eva Luise und Horst K\u00f6hler Stiftung & Else Kr\u00f6ner-Fresenius-Stiftung","award":["2019_KollegSE.03"],"award-info":[{"award-number":["2019_KollegSE.03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and evaluate their relevance as potential monitoring parameters in 21OHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Cross-sectional single-center study including 59 patients with classic 21OHD (men\u2005=\u200530; women\u2005=\u200529) and 49 body mass index- and age-matched controls (men\u2005=\u200519; women\u2005=\u200530).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measures<\/jats:title>\n                    <jats:p>Salivary concentrations of the following steroids were analyzed by liquid chromatography-tandem mass spectrometry: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11\u03b2-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Similar to the previously described rhythmicity of 17OHP, 11OHA4 and 11KT concentrations followed a distinct diurnal rhythm in both patients and controls with highest concentrations in the early morning and declining throughout the day (11-OHA4: mean reduction of hormone concentrations between timepoint 1 and 5 (\u0394\u200amean) in male patients\u2005=\u200566%; male controls \u0394\u200amean\u2005=\u200583%; female patients \u0394\u200amean\u2005=\u200547%; female controls \u0394\u200amean\u2005=\u200586%; 11KT: male patients \u0394\u200amean\u2005=\u200557%; male controls \u0394\u200amean\u2005=\u200563%; female patients \u0394\u200amean\u2005=\u200550%; female controls \u0394\u200amean\u2005=\u200576%). Significant correlations between the area under the curve for 17OHP and 11KT (rpmale\u2005=\u20050.773&amp;lt;0.0001; rpfemale\u2005=\u20050.737&amp;lt;0.0001), and 11OHA4 (rpmale\u2005=\u20050.6330.0002; rpfemale\u2005=\u20050.5640.0014) were observed in patients but not present or reduced in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adrenal 11oxC19 androgens are secreted following a diurnal pattern. This should be considered when evaluating their utility for monitoring treatment control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab446","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T10:19:05Z","timestamp":1624529945000},"page":"e4509-e4519","source":"Crossref","is-referenced-by-count":20,"title":["Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia"],"prefix":"10.1210","volume":"106","author":[{"given":"Hanna Franziska","family":"Nowotny","sequence":"first","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias K","family":"Auer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen, Munich, 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