{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:34:39Z","timestamp":1791653679218,"version":"4.3.4"},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministero dell\u2019Istruzione dell\u2019Universit\u00e0 e della Ricerca \u201cProgetti di Ricerca di Interesse Nazionale\u201d"},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2013-02356459"],"award-info":[{"award-number":["RF-2013-02356459"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EFSD\/Sanofi"},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministero dell\u2019Istruzione dell\u2019Universit\u00e0 e della Ricerca Progetti di Ricerca di Interesse Nazionale","award":["PRIN 2015MPESJS_004"],"award-info":[{"award-number":["PRIN 2015MPESJS_004"]}]},{"name":"Ministero dell\u2019Istruzione dell\u2019Universit\u00e0 e della Ricerca Progetti di Ricerca di Interesse Nazionale","award":["2017FM74HK"],"award-info":[{"award-number":["2017FM74HK"]}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["875534"],"award-info":[{"award-number":["875534"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Type 2 diabetes (T2D) shows a high mortality rate, partly mediated by atherosclerotic plaque instability. Discovering novel biomarkers may help identify high-risk patients who would benefit from more aggressive and specific managements. We recently described a serum resistin and multicytokine inflammatory pathway (REMAP), including resistin, interleukin (IL)-1\u03b2, IL-6, IL-8, and TNF-\u03b1, that is associated with cardiovascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We investigated whether REMAP is associated with and improves the prediction of mortality in T2D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A REMAP score was investigated in 3 cohorts comprising 1528 patients with T2D (409 incident deaths) and in 59 patients who underwent carotid endarterectomy (CEA; 24 deaths). Plaques were classified as unstable\/stable according to the modified American Heart Association atherosclerosis classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>REMAP was associated with all-cause mortality in each cohort and in all 1528 individuals (fully adjusted hazard ratio [HR] for 1 SD increase\u2005=\u20051.34, P\u2005&amp;lt;\u2005.001). In CEA patients, REMAP was associated with mortality (HR\u2005=\u20051.64, P\u2005=\u2005.04) and a modest change was observed when plaque stability was taken into account (HR\u2005=\u20051.58; P\u2005=\u2005.07). REMAP improved discrimination and reclassification measures of both Estimation of Mortality Risk in Type 2 Diabetic Patients and Risk Equations for Complications of Type 2 Diabetes, well-established prediction models of mortality in T2D (P\u2005&amp;lt;\u2005.05-&amp;lt;\u2005.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>REMAP is independently associated with and improves predict all-cause mortality in T2D; it can therefore be used to identify high-risk individuals to be targeted with more aggressive management. Whether REMAP can also identify patients who are more responsive to IL-6 and IL-1\u03b2 monoclonal antibodies that reduce cardiovascular burden and total mortality is an intriguing possibility to be tested.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab472","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T19:01:54Z","timestamp":1625079714000},"page":"e4350-e4359","source":"Crossref","is-referenced-by-count":9,"title":["A Serum Resistin and Multicytokine Inflammatory Pathway Is Linked With and Helps Predict All-cause Death in Diabetes"],"prefix":"10.1210","volume":"106","author":[{"given":"Maria Giovanna","family":"Scarale","sequence":"first","affiliation":[{"name":"Research Unit of Diabetes and Endocrine Diseases, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d 71013 San Giovanni Rotondo, 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