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The change in the levels of most metabolic measures during pregnancy was smaller in obese than in normal weight women. GDM, preeclampsia, and chronic hypertension were associated with metabolic alterations similar to obesity. The associations of obesity held after adjustment for GDM and hypertensive disorders, but many of the associations with GDM and hypertensive disorders were rendered nonsignificant after adjustment for BMI and the other pregnancy disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that the pregnancy-related metabolic change is smaller in women with obesity, who display metabolic perturbations already in early pregnancy. Metabolic alterations of obesity and pregnancy disorders resembled each other suggesting a shared metabolic origin.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgab475","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T15:46:27Z","timestamp":1624981587000},"page":"e4372-e4388","source":"Crossref","is-referenced-by-count":49,"title":["Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-8778","authenticated-orcid":false,"given":"Jemina","family":"Kivel\u00e4","sequence":"first","affiliation":[{"name":"Department of Public Health, University of Helsinki, Helsinki, Finland"},{"name":"Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 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M","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Hyvink\u00e4\u00e4 Hospital at Helsinki and Uusimaa Hospital District, Hyvink\u00e4\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, Queen\u2019s Medical Research Institute, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa K","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Lahti-Pulkkinen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, Faculty of Medicine, 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