{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:17:11Z","timestamp":1787653031688,"version":"build-2736575974"},"reference-count":91,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP136790"],"award-info":[{"award-number":["MOP136790"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP152870"],"award-info":[{"award-number":["MOP152870"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Intrauterine growth restriction (IUGR) is an immediate outcome of an adverse womb environment, exposing newborns to developing cardiometabolic disorders later in life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study investigates the cardiac metabolic consequences and underlying mechanism of energy expenditure in developing fetuses under conditions of IUGR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using an animal model of IUGR characterized by uteroplacental vascular insufficiency, mitochondrial function, gene profiling, lipidomic analysis, and transcriptional assay were determined in fetal cardiac tissue and cardiomyocytes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>IUGR fetuses exhibited an upregulation of key genes associated with fatty acid breakdown and \u03b2-oxidation (Acadvl, Acadl, Acaa2), and mitochondrial carnitine shuttle (Cpt1a, Cpt2), instigating a metabolic gene reprogramming in the heart. Induction of Ech1, Acox1, Acox3, Acsl1, and Pex11a indicated a coordinated interplay with peroxisomal \u03b2-oxidation and biogenesis mainly observed in females, suggesting sexual dimorphism in peroxisomal activation. Concurring with the sex-related changes, mitochondrial respiration rates were stronger in IUGR female fetal cardiomyocytes, accounting for enhanced adenosine 5\u2032-triphosphate production. Mitochondrial biogenesis was induced in fetal hearts with elevated expression of Ppargc1a transcript specifically in IUGR females. Lipidomic analysis identified the accumulation of arachidonic, eicosapentaenoic, and docosapentaenoic polyunsaturated long-chain fatty acids (LCFAs) in IUGR fetal hearts, which leads to nuclear receptor peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) transcriptional activation in cardiomyocytes. Also, the enrichment of H3K27ac chromatin marks to PPAR\u03b1-responsive metabolic genes in IUGR fetal hearts outlines an epigenetic control in the early metabolic energy switch.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study describes a premature and sex-related remodeling of cardiac metabolism in response to an unfavorable intrauterine environment, with specific LCFAs that may serve as predictive effectors leading to IUGR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab496","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T15:21:56Z","timestamp":1625930516000},"page":"3295-3311","source":"Crossref","is-referenced-by-count":20,"title":["Fetal Cardiac Lipid Sensing Triggers an Early and Sex-related Metabolic Energy Switch in Intrauterine Growth Restriction"],"prefix":"10.1210","volume":"106","author":[{"given":"Lo\u00efze","family":"Mar\u00e9chal","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Physiology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3T 1J4, Canada"},{"name":"Research Center, CHU Ste-Justine, Montr\u00e9al, Quebec H3T 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Sicotte","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Physiology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Caron","sequence":"additional","affiliation":[{"name":"Research Center, CHU Ste-Justine, Montr\u00e9al, Quebec H3T 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-8702","authenticated-orcid":false,"given":"Mich\u00e8le","family":"Brochu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Physiology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-9846","authenticated-orcid":false,"given":"Andr\u00e9","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Research Center, CHU Ste-Justine, Montr\u00e9al, Quebec H3T 1C5, Canada"},{"name":"Department of Obstetrics & Gynecology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3T 1J4, Canada"},{"name":"Centre de Recherche en Reproduction et Fertilit\u00e9, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, Quebec J2S 2M2, 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