{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:01:27Z","timestamp":1765976487433,"version":"3.41.2"},"reference-count":43,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The SAGIT\u00ae instrument (SAGIT) has been developed to enable accurate characterization of acromegaly disease activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We evaluated the ability of SAGIT to discriminate acromegaly disease control status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicenter, noninterventional, prospective and retrospective, longitudinal study, conducted at academic and private clinical practice sites, included patients aged\u2005\u2265\u200518 years with a diagnosis of controlled (n\u2005=\u2005109) or non-controlled (n\u2005=\u2005105) acromegaly, assessed by clinical global evaluation of disease control (CGE-DC) questionnaire, investigator therapeutic decision, and international guidelines. Control status was not determined at baseline for 13 patients. Since 9 patients were enrolled retrospectively, all presented analyses are based on the prospective population (N\u2005=\u2005227). Patients were assessed over a 2-year follow-up period. Classification and regression tree (CART) analyses were performed to investigate how SAGIT components at baseline (signs\/symptoms [S], associated comorbidities [A], growth hormone levels [G], insulin-like growth factor 1 levels [I], tumor features [T]) discriminate between controlled and non-controlled acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Baseline mean subscores S, G, I, and T were significantly lower in patients with CGE-DC controlled vs CGE-DC non-controlled acromegaly. SAGIT components I and G for CGE-DC and S, A, G, I, and T for the clinician\u2019s therapeutic decision were retained by CART analyses. For international guidelines, only SAGIT component I was retained. The risk for undergoing \u2265 1 treatment change during the study was 3.44 times greater for CGE-DC non-controlled acromegaly relative to CGE-DC controlled acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The SAGIT instrument is a valid and sensitive tool to comprehensively and accurately assess acromegaly severity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab536","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T16:33:31Z","timestamp":1627403611000},"source":"Crossref","is-referenced-by-count":8,"title":["International Multicenter Validation Study of the SAGIT\u00ae Instrument in Acromegaly"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-3398","authenticated-orcid":false,"given":"Andrea","family":"Giustina","sequence":"first","affiliation":[{"name":"Institute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, 20132, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello D","family":"Bronstein","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo, S\u00e3o Paulo-SP, 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-5722","authenticated-orcid":false,"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction 94270, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Petersenn","sequence":"additional","affiliation":[{"name":"ENDOC Centre for Endocrine Tumours, 22587 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe F","family":"Casanueva","sequence":"additional","affiliation":[{"name":"Instituto Salud Carlos III, 15706 Santiago de Compostela University \u2013 CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Sert","sequence":"additional","affiliation":[{"name":"Ipsen, Boulogne-Billancourt Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"Houchard","sequence":"additional","affiliation":[{"name":"Ipsen, Boulogne-Billancourt Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-3447","authenticated-orcid":false,"given":"Shlomo","family":"Melmed","sequence":"additional","affiliation":[{"name":"Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"issue":"11","key":"2021082711214890200_CIT0001","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1172\/JCI39375","article-title":"Acromegaly pathogenesis and treatment","volume":"119","author":"Melmed","year":"2009","journal-title":"J Clin Invest."},{"issue":"10","key":"2021082711214890200_CIT0002","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJMra1810772","article-title":"Pituitary-Tumor Endocrinopathies","volume":"382","author":"Melmed","year":"2020","journal-title":"N Engl J Med."},{"issue":"1","key":"2021082711214890200_CIT0003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11102-016-0754-x","article-title":"Epidemiology of acromegaly: review of population 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