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Assessments included magnetic resonance imaging to quantify hepatic and abdominal fats, fasting blood draws to measure metabolic markers, and air displacement plethysmography to measure body composition (fat mass and fat-free mass).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median (interquartile range) for hepatic fat was 1.65% (1.24%, 2.11%). Log-transformed hepatic fat was higher in Hispanic [mean (95% CI): 0.63 (0.52, 0.74)] vs non-Hispanic white children [0.46 (0.38, 0.53), P = 0.01] and children with overweight\/obesity [0.64 (0.49, 0.79)] vs normal-weight [0.47 (0.40, 0.53), P = 0.02]. Higher log-hepatic fat was associated with higher insulin [\u03b2 (95% CI): 1.47 (0.61, 2.33) uIU\/mL, P = 0.001] and estimated insulin resistance (homeostatic model assessment) [0.40 (0.20, 0.60), P &amp;lt; 0.001] in the full sample and glucose [5.53 (2.84, 8.21) mg\/dL, P &amp;lt; 0.001] and triglycerides [10.92 (2.92,18.91) mg\/dL, P = 0.008] in boys, in linear regression models adjusted for sociodemographics, maternal\/perinatal confounders, and percentage body fat. Log-hepatic fat was also associated with abdominal subcutaneous adipose tissue [SAT; 7.37 (1.12,13.60) mm2, P = 0.02] in unadjusted models, but this was attenuated and insignificant after adjusting for confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>While hepatic fat was low in children 4 to 8 years old, it was independently associated with estimated insulin resistance and exhibited sex-specific associations with glucose and triglycerides, suggesting hepatic fat may be an early indicator of metabolic dysfunction in youth.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab541","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T17:51:05Z","timestamp":1626889865000},"page":"3140-3150","source":"Crossref","is-referenced-by-count":18,"title":["Hepatic Fat in Early Childhood Is Independently Associated With Estimated Insulin 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