{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:48Z","timestamp":1787021268281,"version":"build-2736575974"},"reference-count":115,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u00a0DK113627"],"award-info":[{"award-number":["R01\u00a0DK113627"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19\u00a0AG60917"],"award-info":[{"award-number":["U19\u00a0AG60917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG071870"],"award-info":[{"award-number":["R01 AG071870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyrotropin (TSH), traditionally seen as a pituitary hormone that regulates thyroid glands, has additional roles in physiology including skeletal remodeling. Population-based observations in people with euthyroidism or subclinical hyperthyroidism indicated a negative association between bone mass and low-normal TSH. The findings of correlative studies were supported by small intervention trials using recombinant human TSH (rhTSH) injection, and genetic and case-based evidence. Genetically modified mouse models, which disrupt the reciprocal relationship between TSH and thyroid hormone, have allowed us to examine an independent role of TSH. Since the first description of osteoporotic phenotype in haploinsufficient Tshr+\/\u2013 mice with normal thyroid hormone levels, the antiosteoclastic effect of TSH has been documented in both in vitro and in vivo studies. Further studies showed that increased osteoclastogenesis in Tshr-deficient mice was mediated by tumor necrosis factor \u03b1. Low TSH not only increased osteoclastogenesis, but also decreased osteoblastogenesis in bone marrow\u2013derived primary osteoblast cultures. However, later in vivo studies using small and intermittent doses of rhTSH showed a proanabolic effect, which suggests that its action might be dose and frequency dependent. TSHR was shown to interact with insulin-like growth factor 1 receptor, and vascular endothelial growth factor and Wnt pathway might play a role in TSH\u2019s effect on osteoblasts. The expression and direct skeletal effect of a biologically active splice variant of the TSH\u03b2 subunit (TSH\u03b2v) in bone marrow\u2013derived macrophage and other immune cells suggest a local skeletal effect of TSHR. Further studies of how locally secreted TSH\u03b2v and systemic TSH\u03b2 interact in skeletal remodeling through the endocrine, immune, and skeletal systems will help us better understand the hyperthyroidism-induced bone disease.<\/jats:p>","DOI":"10.1210\/clinem\/dgab548","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T07:20:30Z","timestamp":1627456830000},"source":"Crossref","is-referenced-by-count":19,"title":["Thyrotropin, Hyperthyroidism, and Bone Mass"],"prefix":"10.1210","author":[{"given":"Se-Min","family":"Kim","sequence":"first","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Ryu","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Miyashita","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Lizneva","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Gera","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauf","family":"Latif","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry F","family":"Davies","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameel","family":"Iqbal","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Yuen","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-9522","authenticated-orcid":false,"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"2021082811205642100_CIT0001","article-title":"Die fibr\u00f6se oder deformierende Ostitis, die Osteomalazie und die osteoplastische Carcinose in ihren gegenseitigen Beziehungen","volume-title":"Festschrift f\u00fcr Rudolf Virchow.","author":"von Recklinghausen","year":"1891"},{"issue":"3","key":"2021082811205642100_CIT0002","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/acta.0.0850515","article-title":"Bone changes in hyperthyroidism: interrelationships between bone morphometry, thyroid function and calcium-phosphorus metabolism","volume":"85","author":"Mosekilde","year":"1977","journal-title":"Acta Endocrinol (Copenh)."},{"issue":"3","key":"2021082811205642100_CIT0003","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI108497","article-title":"Direct stimulation of bone resorption by thyroid hormones","volume":"58","author":"Mundy","year":"1976","journal-title":"J Clin Invest."},{"issue":"1","key":"2021082811205642100_CIT0004","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0026-0495(86)90098-3","article-title":"Nuclear thyroid hormone receptors in cultured bone cells","volume":"35","author":"Rizzoli","year":"1986","journal-title":"Metabolism."},{"issue":"1","key":"2021082811205642100_CIT0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s40618-017-0753-4","article-title":"Thyroid diseases and bone health","volume":"41","author":"Williams","year":"2018","journal-title":"J Endocrinol Invest."},{"issue":"2","key":"2021082811205642100_CIT0006","first-page":"91","article-title":"Analysis of skeletal phenotypes in thyroid hormone receptor mutant mice","volume":"28","author":"Bassett","year":"2006","journal-title":"Scanning."},{"issue":"2","key":"2021082811205642100_CIT0007","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1210\/me.2007-0221","article-title":"A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism","volume":"22","author":"Bassett","year":"2008","journal-title":"Mol Endocrinol."},{"key":"2021082811205642100_CIT0008","first-page":"e011","article-title":"Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression","volume":"4","author":"O\u2019Shea","year":"2006","journal-title":"Nucl Recept Signal."},{"issue":"2","key":"2021082811205642100_CIT0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","article-title":"TSH is a negative regulator of skeletal remodeling","volume":"115","author":"Abe","year":"2003","journal-title":"Cell."},{"issue":"10","key":"2021082811205642100_CIT0010","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1172\/JCI63948","article-title":"Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling","volume":"122","author":"Baliram","year":"2012","journal-title":"J Clin Invest."},{"issue":"4","key":"2021082811205642100_CIT0011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/thy.2007.0166","article-title":"The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels","volume":"18","author":"Martini","year":"2008","journal-title":"Thyroid."},{"issue":"7656","key":"2021082811205642100_CIT0012","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature22342","article-title":"Blocking FSH induces thermogenic adipose tissue and reduces body fat","volume":"546","author":"Liu","year":"2017","journal-title":"Nature."},{"issue":"2","key":"2021082811205642100_CIT0013","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2006.01.051","article-title":"FSH directly regulates bone mass","volume":"125","author":"Sun","year":"2006","journal-title":"Cell."},{"issue":"19","key":"2021082811205642100_CIT0014","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1073\/pnas.0912176107","article-title":"ACTH protects against glucocorticoid-induced osteonecrosis of bone","volume":"107","author":"Zaidi","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"2021082811205642100_CIT0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1073\/pnas.1523762113","article-title":"Functions of vasopressin and oxytocin in bone mass regulation","volume":"113","author":"Sun","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021082811205642100_CIT0016","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JOE-17-0680","article-title":"Actions of pituitary hormones beyond traditional targets","volume":"237","author":"Zaidi","year":"2018","journal-title":"J Endocrinol."},{"issue":"2","key":"2021082811205642100_CIT0017","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2265.2007.03016.x","article-title":"Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study","volume":"68","author":"van der Deure","year":"2008","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"4","key":"2021082811205642100_CIT0018","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bone.2006.12.001","article-title":"The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women","volume":"40","author":"Morris","year":"2007","journal-title":"Bone."},{"issue":"5","key":"2021082811205642100_CIT0019","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2174\/1871530320666200810144506","article-title":"Low normal TSH levels and thyroid autoimmunity are associated with an increased risk of osteoporosis in euthyroid postmenopausal women","volume":"21","author":"Yang","year":"2021","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"3","key":"2021082811205642100_CIT0020","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00198-014-2906-z","article-title":"A cross-sectional study to examine the correlation between serum TSH levels and the osteoporosis of the lumbar spine in healthy women with normal thyroid function","volume":"26","author":"Noh","year":"2015","journal-title":"Osteoporos Int."},{"issue":"1","key":"2021082811205642100_CIT0021","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2265.2005.02422.x","article-title":"Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women","volume":"64","author":"Kim","year":"2006","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"7","key":"2021082811205642100_CIT0022","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1210\/jc.2009-2630","article-title":"Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women","volume":"95","author":"Murphy","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021082811205642100_CIT0023","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bone.2009.10.031","article-title":"Serum TSH values and risk of vertebral fractures in euthyroid post-menopausal women with low bone mineral density","volume":"46","author":"Mazziotti","year":"2010","journal-title":"Bone."},{"issue":"11","key":"2021082811205642100_CIT0024","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/thy.2008.0158","article-title":"The relationship between serum TSH and bone mineral density in men and postmenopausal women: the Troms\u00f8 Study","volume":"18","author":"Grimnes","year":"2008","journal-title":"Thyroid."},{"issue":"8","key":"2021082811205642100_CIT0025","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1210\/jc.2017-00294","article-title":"Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts","volume":"102","author":"Aubert","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021082811205642100_CIT0026","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1210\/jcem.87.3.8165","article-title":"Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease","volume":"87","author":"Andersen","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"9821","key":"2021082811205642100_CIT0027","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/S0140-6736(11)60276-6","article-title":"Subclinical thyroid disease","volume":"379","author":"Cooper","year":"2012","journal-title":"Lancet."},{"issue":"1","key":"2021082811205642100_CIT0028","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/joim.12688","article-title":"Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts","volume":"283","author":"Segna","year":"2018","journal-title":"J Intern Med."},{"issue":"7","key":"2021082811205642100_CIT0029","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-134-7-200104030-00009","article-title":"Risk for fracture in women with low serum levels of thyroid-stimulating hormone","volume":"134","author":"Bauer","year":"2001","journal-title":"Ann Intern Med."},{"issue":"9","key":"2021082811205642100_CIT0030","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/jbmr.2244","article-title":"Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures\u2014the OPENTHYRO register cohort","volume":"29","author":"Abrahamsen","year":"2014","journal-title":"J Bone Miner Res."},{"issue":"20","key":"2021082811205642100_CIT0031","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2015.5161","article-title":"Subclinical thyroid dysfunction and fracture risk: a meta-analysis","volume":"313","author":"Blum","year":"2015","journal-title":"JAMA."},{"issue":"1","key":"2021082811205642100_CIT0032","doi-asserted-by":"crossref","first-page":"31","DOI":"10.11005\/jbm.2019.26.1.31","article-title":"Effects of thyrotropin suppression on bone health in menopausal women with total thyroidectomy","volume":"26","author":"Kim","year":"2019","journal-title":"J Bone Metab."},{"issue":"16","key":"2021082811205642100_CIT0033","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1002\/cam4.3200","article-title":"Trabecular bone deterioration in differentiated thyroid cancer: impact of long-term TSH suppressive therapy","volume":"9","author":"Hawkins Carranza","year":"2020","journal-title":"Cancer Med."},{"issue":"6","key":"2021082811205642100_CIT0034","doi-asserted-by":"crossref","first-page":"734","DOI":"10.14336\/AD.2016.0325","article-title":"Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly","volume":"7","author":"Lee","year":"2016","journal-title":"Aging Dis."},{"issue":"25","key":"2021082811205642100_CIT0035","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1056\/NEJMcp1709318","article-title":"Subclinical hyperthyroidism","volume":"378","author":"Biondi","year":"2018","journal-title":"N Engl J Med."},{"issue":"4","key":"2021082811205642100_CIT0036","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1530\/eje.0.1300350","article-title":"Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis","volume":"130","author":"Faber","year":"1994","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2021082811205642100_CIT0037","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/thy.2006.16.583","article-title":"The effects of thyrotropin-suppressive therapy on bone metabolism in patients with well-differentiated thyroid carcinoma","volume":"16","author":"Heemstra","year":"2006","journal-title":"Thyroid."},{"issue":"1","key":"2021082811205642100_CIT0038","doi-asserted-by":"crossref","first-page":"51","DOI":"10.11005\/jbm.2019.26.1.51","article-title":"Influence of thyroid-stimulating hormone suppression therapy on bone mineral density in patients with differentiated thyroid cancer: a meta-analysis","volume":"26","author":"Yoon","year":"2019","journal-title":"J Bone Metab."},{"issue":"1","key":"2021082811205642100_CIT0039","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jso.10043","article-title":"Bone mineral density in well-differentiated thyroid cancer patients treated with suppressive thyroxine: a systematic overview of the literature","volume":"79","author":"Quan","year":"2002","journal-title":"J Surg Oncol."},{"issue":"7","key":"2021082811205642100_CIT0040","first-page":"2266","article-title":"Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen","volume":"83","author":"Khosla","year":"1998","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021082811205642100_CIT0041","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrendo.2017.104","article-title":"Primary hyperparathyroidism","volume":"14","author":"Walker","year":"2018","journal-title":"Nat Rev Endocrinol."},{"issue":"3","key":"2021082811205642100_CIT0042","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jbmr.1774","article-title":"A prospective study of thyroid function, bone loss, and fractures in older men: the MrOS Study","volume":"28","author":"Waring","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2021082811205642100_CIT0043","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/cen.13615","article-title":"Subclinical thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men","volume":"89","author":"Siru","year":"2018","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"21","key":"2021082811205642100_CIT0044","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1001\/archinternmed.2010.424","article-title":"Subclinical thyroid dysfunction and incident hip fracture in older adults","volume":"170","author":"Lee","year":"2010","journal-title":"Arch Intern Med."},{"issue":"8","key":"2021082811205642100_CIT0045","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1210\/jc.2014-1051","article-title":"Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the Cardiovascular Health Study","volume":"99","author":"Garin","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021082811205642100_CIT0046","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00198-019-05205-1","article-title":"Subclinical thyroid dysfunction, bone mineral density, and osteoporosis in a middle-aged Korean population","volume":"31","author":"Lee","year":"2020","journal-title":"Osteoporos Int."},{"issue":"3","key":"2021082811205642100_CIT0047","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00198-003-1527-8","article-title":"Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trial","volume":"15","author":"Meier","year":"2004","journal-title":"Osteoporos Int."},{"issue":"3","key":"2021082811205642100_CIT0048","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1359\/JBMR.041126","article-title":"Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma","volume":"20","author":"Mazziotti","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2021082811205642100_CIT0049","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00774-009-0098-y","article-title":"The effects of recombinant human TSH on bone turnover in patients after thyroidectomy","volume":"28","author":"Karga","year":"2010","journal-title":"J Bone Miner Metab."},{"issue":"4","key":"2021082811205642100_CIT0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2265.1994.tb02571.x","article-title":"Bone metabolism during anti-thyroid drug treatment of endogenous subclinical hyperthyroidism","volume":"41","author":"Mudde","year":"1994","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"3","key":"2021082811205642100_CIT0051","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1365-2265.1998.00427.x","article-title":"Normalization of serum thyrotrophin by means of radioiodine treatment in subclinical hyperthyroidism: effect on bone loss in postmenopausal women","volume":"48","author":"Faber","year":"1998","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"2","key":"2021082811205642100_CIT0052","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S0004-27302013000200008","article-title":"Radioiodine therapy in elderly patients with subclinical hyperthyroidism due to non-voluminous nodular goiter and its effect on bone metabolism","volume":"57","author":"Rosario","year":"2013","journal-title":"Arq Bras Endocrinol Metabol."},{"issue":"9","key":"2021082811205642100_CIT0053","first-page":"3328","article-title":"Germline polymorphism of codon 727 of human thyroid-stimulating hormone receptor is associated with toxic multinodular goiter","volume":"84","author":"Gabriel","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"2021082811205642100_CIT0054","first-page":"S341","article-title":"The D727E polymorphism of the human thyroid stimulating hormone receptor is associated with bone mineral density and bone loss in women from the UK","volume":"20","author":"Albagha","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2021082811205642100_CIT0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/1947-2714.98588","article-title":"The Glu727 allele of thyroid stimulating hormone receptor gene is associated with osteoporosis","volume":"4","author":"Liu","year":"2012","journal-title":"N Am J Med Sci."},{"issue":"7","key":"2021082811205642100_CIT0056","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/jbmr.3426","article-title":"Thyroid stimulating hormone and bone mineral density: evidence from a two-sample mendelian randomization study and a candidate gene association study","volume":"33","author":"van Vliet","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2021082811205642100_CIT0057","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1507\/endocrj.K10E-329","article-title":"A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto\u2019s thyroiditis","volume":"58","author":"Iida","year":"2011","journal-title":"Endocr J."},{"issue":"24","key":"2021082811205642100_CIT0058","doi-asserted-by":"crossref","first-page":"9891","DOI":"10.1073\/pnas.1308336110","article-title":"Genetic confirmation for a central role for TNF\u03b1 in the direct action of thyroid stimulating hormone on the skeleton","volume":"110","author":"Sun","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2021082811205642100_CIT0059","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/endo.136.7.7789342","article-title":"The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt\/hyt mouse results in plasma membrane targeting but defective TSH binding","volume":"136","author":"Gu","year":"1995","journal-title":"Endocrinology."},{"issue":"11","key":"2021082811205642100_CIT0060","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1073\/pnas.0712395105","article-title":"Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss","volume":"105","author":"Sun","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021082811205642100_CIT0061","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/en.2002-220715","article-title":"Regulation of iodothyronine deiodinases in the Pax8\u2013\/\u2013 mouse model of congenital hypothyroidism","volume":"144","author":"Friedrichsen","year":"2003","journal-title":"Endocrinology."},{"key":"2021082811205642100_CIT0062","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fimmu.2014.00155","article-title":"Biological impact of the TSH\u03b2 splice variant in health and disease","volume":"5","author":"Klein","year":"2014","journal-title":"Front Immunol."},{"issue":"12","key":"2021082811205642100_CIT0063","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1210\/en.2012-2234","article-title":"Thyroid and bone: macrophage-derived TSH-\u03b2 splice variant increases murine osteoblastogenesis","volume":"154","author":"Baliram","year":"2013","journal-title":"Endocrinology."},{"issue":"9","key":"2021082811205642100_CIT0064","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1210\/en.2015-1974","article-title":"T3 regulates a human macrophage-derived TSH-\u03b2 splice variant: implications for human bone biology","volume":"157","author":"Baliram","year":"2016","journal-title":"Endocrinology."},{"issue":"5","key":"2021082811205642100_CIT0065","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1080\/07391102.2014.932310","article-title":"Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain","volume":"33","author":"Ali","year":"2015","journal-title":"J Biomol Struct Dyn."},{"issue":"2","key":"2021082811205642100_CIT0066","doi-asserted-by":"crossref","first-page":"221","DOI":"10.20945\/2359-3997000000027","article-title":"TSH-receptor antibodies may prevent bone loss in pre- and postmenopausal women with Graves\u2019 disease and Graves\u2019 orbitopathy","volume":"62","author":"Siderova","year":"2018","journal-title":"Arch Endocrinol Metab."},{"issue":"8","key":"2021082811205642100_CIT0067","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1089\/thy.2010.0457","article-title":"The influence of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on osteoclastogenesis","volume":"21","author":"Ma","year":"2011","journal-title":"Thyroid."},{"issue":"2","key":"2021082811205642100_CIT0068","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1006\/bbrc.1998.9661","article-title":"Genomic organization of a receptor from sea anemones, structurally and evolutionarily related to glycoprotein hormone receptors from mammals","volume":"252","author":"Vibede","year":"1998","journal-title":"Biochem Biophys Res Commun."},{"issue":"1-2","key":"2021082811205642100_CIT0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0303-7207(00)00304-X","article-title":"Cloning and functional expression of a thyrotropin receptor from the gonads of a vertebrate (bony fish): potential thyroid-independent role for thyrotropin in reproduction","volume":"167","author":"Kumar","year":"2000","journal-title":"Mol Cell Endocrinol."},{"issue":"2","key":"2021082811205642100_CIT0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI0216234","article-title":"The TSH receptor reveals itself","volume":"110","author":"Davies","year":"2002","journal-title":"J Clin Invest."},{"issue":"5","key":"2021082811205642100_CIT0071","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00223-003-0108-3","article-title":"Weak evidence of thyrotropin receptors in primary cultures of human osteoblast-like cells","volume":"74","author":"Tsai","year":"2004","journal-title":"Calcif Tissue Int."},{"issue":"11","key":"2021082811205642100_CIT0072","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/thy.1998.8.1059","article-title":"Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells","volume":"8","author":"Inoue","year":"1998","journal-title":"Thyroid."},{"issue":"6","key":"2021082811205642100_CIT0073","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1359\/jbmr.070302","article-title":"Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats","volume":"22","author":"Sampath","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2021082811205642100_CIT0074","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1210\/jc.2004-1260","article-title":"Thyrotropin (TSH)-induced production of vascular endothelial growth factor in thyroid cancer cells in vitro: evaluation of TSH signal transduction and of angiogenesis-stimulating growth factors","volume":"89","author":"Hoffmann","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2021082811205642100_CIT0075","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/mend.14.5.0458","article-title":"Involvement of JAK\/STAT (Janus kinase\/signal transducer and activator of transcription) in the thyrotropin signaling pathway","volume":"14","author":"Park","year":"2000","journal-title":"Mol Endocrinol."},{"issue":"3","key":"2021082811205642100_CIT0076","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/mend.14.3.0433","article-title":"Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells","volume":"14","author":"Park","year":"2000","journal-title":"Mol Endocrinol."},{"issue":"34","key":"2021082811205642100_CIT0077","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1073\/pnas.0600427103","article-title":"TNFalpha mediates the skeletal effects of thyroid-stimulating hormone","volume":"103","author":"Hase","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2021082811205642100_CIT0078","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1365-2265.2002.01629.x","article-title":"Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function","volume":"57","author":"D\u00edez","year":"2002","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"40","key":"2021082811205642100_CIT0079","doi-asserted-by":"crossref","first-page":"14925","DOI":"10.1073\/pnas.0606805103","article-title":"Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation","volume":"103","author":"Iqbal","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"2021082811205642100_CIT0080","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1210\/me.2007-0460","article-title":"High-mobility group box proteins modulate tumor necrosis factor-alpha expression in osteoclastogenesis via a novel deoxyribonucleic acid sequence","volume":"22","author":"Yamoah","year":"2008","journal-title":"Mol Endocrinol."},{"issue":"1","key":"2021082811205642100_CIT0081","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1182\/blood-2002-02-0544","article-title":"An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells","volume":"101","author":"Wang","year":"2003","journal-title":"Blood."},{"issue":"5","key":"2021082811205642100_CIT0082","first-page":"4514","article-title":"HPT axis-independent TSH\u03b2 splice variant regulates the synthesis of thyroid hormone in mice","volume":"19","author":"Liu","year":"2019","journal-title":"Mol Med Rep."},{"issue":"6","key":"2021082811205642100_CIT0083","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1210\/jcem-71-6-1567","article-title":"Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man","volume":"71","author":"van der Poll","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021082811205642100_CIT0084","doi-asserted-by":"crossref","first-page":"e0146111","DOI":"10.1371\/journal.pone.0146111","article-title":"Splenic leukocytes traffic to the thyroid and produce a novel TSH\u03b2 isoform during acute listeria monocytogenes infection in mice","volume":"11","author":"Montufar-Solis","year":"2016","journal-title":"PLoS One."},{"issue":"1-2","key":"2021082811205642100_CIT0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-012-1345-4","article-title":"Regulation of insulin-like growth factors and their binding proteins by thyroid stimulating hormone in human osteoblast-like (SaOS2) cells","volume":"368","author":"Ramajayam","year":"2012","journal-title":"Mol Cell Biochem."},{"key":"2021082811205642100_CIT0086","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fendo.2020.00312","article-title":"\u03b2-arrestin 1 in thyrotropin receptor signaling in bone: studies in osteoblast-like cells","volume":"11","author":"Boutin","year":"2020","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"8","key":"2021082811205642100_CIT0087","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1096\/fj.14-251124","article-title":"\u03b2-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation","volume":"28","author":"Boutin","year":"2014","journal-title":"FASEB J."},{"issue":"2","key":"2021082811205642100_CIT0088","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI82585","article-title":"Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair","volume":"126","author":"Hu","year":"2016","journal-title":"J Clin Invest."},{"issue":"9","key":"2021082811205642100_CIT0089","doi-asserted-by":"crossref","first-page":"e135355","DOI":"10.1172\/jci.insight.135355","article-title":"Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing","volume":"5","author":"Schall","year":"2020","journal-title":"JCI Insight"},{"issue":"12","key":"2021082811205642100_CIT0090","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1359\/jbmr.070806","article-title":"Thyroid hormone interacts with the Wnt\/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes","volume":"22","author":"Wang","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"14","key":"2021082811205642100_CIT0091","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/MCB.02192-07","article-title":"Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor","volume":"28","author":"Guigon","year":"2008","journal-title":"Mol Cell Biol."},{"issue":"21","key":"2021082811205642100_CIT0092","doi-asserted-by":"crossref","first-page":"17812","DOI":"10.1074\/jbc.M111.311464","article-title":"Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor \u03b2 gene due to activation of Wnt\/\u03b2-catenin protein signaling","volume":"287","author":"O\u2019Shea","year":"2012","journal-title":"J Biol Chem."},{"issue":"10","key":"2021082811205642100_CIT0093","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/en.2015-1073","article-title":"Hyperthyroidism and hypothyroidism in male mice and their effects on bone mass, bone turnover, and the Wnt inhibitors sclerostin and dickkopf-1","volume":"156","author":"Tsourdi","year":"2015","journal-title":"Endocrinology."},{"issue":"10","key":"2021082811205642100_CIT0094","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/jbmr.4092","article-title":"Disruption of BMP signaling prevents hyperthyroidism-induced bone loss in male mice","volume":"35","author":"Lademann","year":"2020","journal-title":"J Bone Miner Res."},{"issue":"39","key":"2021082811205642100_CIT0095","doi-asserted-by":"crossref","first-page":"16277","DOI":"10.1073\/pnas.1110286108","article-title":"Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures","volume":"108","author":"Baliram","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2021082811205642100_CIT0096","first-page":"2557","article-title":"Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor","volume":"84","author":"Valyasevi","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"2021082811205642100_CIT0097","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0083-6729(08)60658-5","article-title":"The thyrotropin receptor","volume":"50","author":"Kohn","year":"1995","journal-title":"Vitam Horm."},{"issue":"2","key":"2021082811205642100_CIT0098","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/cimm.1995.1040","article-title":"Hormonal regulation of extrathymic gut T cell development: involvement of thyroid stimulating hormone","volume":"161","author":"Wang","year":"1995","journal-title":"Cell Immunol."},{"issue":"10","key":"2021082811205642100_CIT0099","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1001\/archinternmed.2012.402","article-title":"Subclinical hyperthyroidism and the risk of coronary heart disease and mortality","volume":"172","author":"Collet","year":"2012","journal-title":"Arch Intern Med."},{"issue":"12","key":"2021082811205642100_CIT0100","doi-asserted-by":"crossref","first-page":"e005266","DOI":"10.1161\/CIRCHEARTFAILURE.118.005266","article-title":"Thyroid dysfunction in heart failure and cardiovascular outcomes","volume":"11","author":"Kannan","year":"2018","journal-title":"Circ Heart Fail."},{"issue":"5","key":"2021082811205642100_CIT0101","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1210\/en.2018-01048","article-title":"A modifying autoantigen in Graves\u2019 disease","volume":"160","author":"Latif","year":"2019","journal-title":"Endocrinology."},{"issue":"46","key":"2021082811205642100_CIT0102","doi-asserted-by":"crossref","first-page":"18644","DOI":"10.1073\/pnas.1318257110","article-title":"Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia","volume":"110","author":"Tamma","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"9","key":"2021082811205642100_CIT0103","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1073\/pnas.1718144115","article-title":"Epitope-specific monoclonal antibodies to FSH\u03b2 increase bone mass","volume":"115","author":"Ji","year":"2018","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"36","key":"2021082811205642100_CIT0104","doi-asserted-by":"crossref","first-page":"14574","DOI":"10.1073\/pnas.1212806109","article-title":"Blocking antibody to the \u03b2-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2021082811205642100_CIT0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.theriogenology.2020.03.005","article-title":"A novel follicle-stimulating hormone vaccine for controlling fat accumulation","volume":"148","author":"Han","year":"2020","journal-title":"Theriogenology."},{"issue":"2","key":"2021082811205642100_CIT0106","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbrc.2013.02.116","article-title":"Immunization with FSH\u03b2 fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model","volume":"434","author":"Geng","year":"2013","journal-title":"Biochem Biophys Res Commun."},{"issue":"2","key":"2021082811205642100_CIT0107","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41422-018-0123-6","article-title":"Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol","volume":"29","author":"Guo","year":"2019","journal-title":"Cell Res."},{"issue":"1","key":"2021082811205642100_CIT0108","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1210\/jc.2015-2724","article-title":"Follicle-stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism","volume":"101","author":"Song","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"46","key":"2021082811205642100_CIT0109","doi-asserted-by":"crossref","first-page":"28971","DOI":"10.1073\/pnas.2014588117","article-title":"First-in-class humanized FSH blocking antibody targets bone and fat","volume":"117","author":"Gera","year":"2020","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"52","key":"2021082811205642100_CIT0110","doi-asserted-by":"crossref","first-page":"26808","DOI":"10.1073\/pnas.1913611116","article-title":"Oxytocin regulates body composition","volume":"116","author":"Sun","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2021082811205642100_CIT0111","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1073\/pnas.0901890106","article-title":"Oxytocin is an anabolic bone hormone","volume":"106","author":"Tamma","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2021082811205642100_CIT0112","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2009.05231.x","article-title":"ACTH is a novel regulator of bone mass","volume":"1192","author":"Isales","year":"2010","journal-title":"Ann N Y Acad Sci."},{"key":"2021082811205642100_CIT0113","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1476-511X-11-17","article-title":"Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity","volume":"11","author":"Lu","year":"2012","journal-title":"Lipids Health Dis."},{"issue":"25","key":"2021082811205642100_CIT0114","doi-asserted-by":"crossref","first-page":"22991","DOI":"10.1074\/jbc.M102244200","article-title":"A conserved Asn in transmembrane helix 7 is an on\/off switch in the activation of the thyrotropin receptor","volume":"276","author":"Govaerts","year":"2001","journal-title":"J Biol Chem."},{"issue":"10","key":"2021082811205642100_CIT0115","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1101\/gad.13.10.1329","article-title":"Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation","volume":"13","author":"G\u00f6the","year":"1999","journal-title":"Genes Dev."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab548\/40078412\/dgab548.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab548\/40078412\/dgab548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T10:33:53Z","timestamp":1699266833000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article\/doi\/10.1210\/clinem\/dgab548\/6329374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":115,"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab548","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]},"article-number":"dgab548"}}