{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:01:14Z","timestamp":1788861674090,"version":"build-2803163510"},"reference-count":34,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Cardiovascular disease is the leading cause of death in patients with Cushing syndrome. Cortisol excess and adverse metabolic profile could increase cardiac fat, which can subsequently impair cardiac structure and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate cardiac fat mass and distribution in patients with Cushing syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, cross-sectional study, 23 patients with Cushing syndrome and 27 control individuals of comparable age, sex, and body mass index were investigated by cardiac magnetic resonance imaging and proton spectroscopy. Patients were explored before and after biochemical disease remission. Myocardial fat measured by the Dixon method was the main outcome measure. The intramyocardial triglyceride\/water ratio measured by spectroscopy and epicardial and pericardial fat volumes were secondary outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No difference was found between patients and controls in intramyocardial lipid content. Epicardial fat mass was increased in patients compared to controls (30.8 g\/m2 [20.4-34.8] vs 17.2 g\/m2 [13.1-23.5], P\u2005&amp;lt;\u2005.001). Similarly, pericardial fat mass was increased in patients compared to controls (28.3 g\/m2 [17.9-38.0] vs 11.4 g\/m2 [7.5-19.4], P\u2005=\u2005.003). Sex, glycated hemoglobin A1c, and the presence of hypercortisolism were independent determinants of epicardial fat. Pericardial fat was associated with sex, impaired glucose homeostasis and left ventricular wall thickness. Disease remission decreased epicardial fat mass without affecting pericardial fat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intramyocardial fat stores are not increased in patients with Cushing syndrome, despite highly prevalent metabolic syndrome, suggesting increased cortisol-mediated lipid consumption. Cushing syndrome is associated with marked accumulation of epicardial and pericardial fat. Epicardial adiposity may exert paracrine proinflammatory effects promoting cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab556","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T11:30:09Z","timestamp":1627817409000},"source":"Crossref","is-referenced-by-count":9,"title":["Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-734X","authenticated-orcid":false,"given":"Peter","family":"Wolf","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Medical University of Vienna, Department of Internal Medicine III, Division of Endocrinology and Metabolism, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-647X","authenticated-orcid":false,"given":"Benjamin","family":"Marty","sequence":"additional","affiliation":[{"name":"Institut de Myologie, CEA, Laboratoire de R\u00e9sonance Magn\u00e9tique Nucl\u00e9aire, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaoula","family":"Bouazizi","sequence":"additional","affiliation":[{"name":"Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9, CNRS, Inserm, Laboratoire d\u2019Imagerie Biom\u00e9dicale, LIB, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadjia","family":"Kachenoura","sequence":"additional","affiliation":[{"name":"Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9, CNRS, Inserm, Laboratoire d\u2019Imagerie Biom\u00e9dicale, LIB, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Piedvache","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Unit\u00e9 de Recherche Clinique, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-0586","authenticated-orcid":false,"given":"Anne","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Assistance Publique des H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges-Pompidou, Centre d\u2019Investigations Cliniques, Inserm CIC1318 et UMR 1138, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika\u00ebl","family":"Prigent","sequence":"additional","affiliation":[{"name":"Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Jublanc","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Endocrinologie-M\u00e9tabolisme, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Ajzenberg","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Henri-Mondor, Service de M\u00e9decine Interne, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Droumaguet","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Henri-Mondor, Service de M\u00e9decine Interne, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-5631","authenticated-orcid":false,"given":"Jacques","family":"Young","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Lecoq","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Agostini","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Unit\u00e9 de Recherche Clinique, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Trabado","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service de G\u00e9n\u00e9tique Mol\u00e9culaire, Pharmacog\u00e9n\u00e9tique et Hormonologie, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre G","family":"Carlier","sequence":"additional","affiliation":[{"name":"Institut de Myologie, CEA, Laboratoire de R\u00e9sonance Magn\u00e9tique Nucl\u00e9aire, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Saint-Antoine, Service d\u2019Endocrinologie et M\u00e9tabolisme, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Insulino-S\u00e9cr\u00e9tion et de l\u2019Insulino-Sensibilit\u00e9 (PRISIS), Sorbonne Universit\u00e9, Inserm, Centre de Recherche Saint-Antoine, UMR-S938, IHU ICAN, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, Inserm, Laboratoire d\u2019Imagerie Biom\u00e9dicale, LIB, 75006 Paris, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Unit\u00e9 d\u2019Imagerie Cardiovasculaire et Thoracique, APHP.SU, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-5722","authenticated-orcid":false,"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-4226","authenticated-orcid":false,"given":"Peter","family":"Kamenick\u00fd","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"issue":"9522","key":"2021082811210396600_CIT0001","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing\u2019s syndrome","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet."},{"issue":"9996","key":"2021082811210396600_CIT0002","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing\u2019s syndrome","volume":"386","author":"Lacroix","year":"2015","journal-title":"Lancet."},{"issue":"7","key":"2021082811210396600_CIT0003","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S2213-8587(16)30005-5","article-title":"Mortality in patients with Cushing\u2019s disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study","volume":"4","author":"Clayton","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"3","key":"2021082811210396600_CIT0004","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1210\/jc.2012-3547","article-title":"Coronary artery disease detected by multislice computed tomography in patients after long-term cure of Cushing\u2019s syndrome","volume":"98","author":"Barahona","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021082811210396600_CIT0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jacc.2015.10.040","article-title":"Atrogin-1 pathway activation in Cushing syndrome cardiomyopathy","volume":"67","author":"Frustaci","year":"2016","journal-title":"J Am Coll Cardiol."},{"issue":"12","key":"2021082811210396600_CIT0006","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/S0735-1097(03)00493-5","article-title":"Left ventricular structural and functional characteristics in Cushing\u2019s syndrome","volume":"41","author":"Muiesan","year":"2003","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"2021082811210396600_CIT0007","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/EJE-09-0621","article-title":"Cardiac dysfunction is reversed upon successful treatment of Cushing\u2019s syndrome","volume":"162","author":"Pereira","year":"2010","journal-title":"Eur J Endocrinol."},{"issue":"1","key":"2021082811210396600_CIT0008","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/EJE-11-0601","article-title":"Increased myocardial fibrosis and left ventricular dysfunction in Cushing\u2019s syndrome","volume":"166","author":"Yiu","year":"2012","journal-title":"Eur J Endocrinol."},{"issue":"3","key":"2021082811210396600_CIT0009","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2265.2011.04206.x","article-title":"Clinical relevance of cardiac structure and function abnormalities in patients with Cushing\u2019s syndrome before and after cure","volume":"76","author":"Toja","year":"2012","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"11","key":"2021082811210396600_CIT0010","doi-asserted-by":"crossref","first-page":"E2144","DOI":"10.1210\/jc.2014-1783","article-title":"Cardiac structure and function in Cushing\u2019s syndrome: a cardiac magnetic resonance imaging study","volume":"99","author":"Kamenick\u00fd","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021082811210396600_CIT0011","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/jmri.25374","article-title":"Effects of cortisol on the heart: characterization of myocardial involvement in Cushing\u2019s disease by longitudinal cardiac MRI T1 mapping","volume":"45","author":"Roux","year":"2017","journal-title":"J Magn Reson Imaging."},{"issue":"10","key":"2021082811210396600_CIT0012","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCULATIONAHA.106.645614","article-title":"Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study","volume":"116","author":"McGavock","year":"2007","journal-title":"Circulation."},{"issue":"12","key":"2021082811210396600_CIT0013","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jcmg.2014.12.019","article-title":"Evidence of a direct effect of myocardial steatosis on LV hypertrophy and diastolic dysfunction in adult and adolescent obesity","volume":"8","author":"Banerjee","year":"2015","journal-title":"JACC Cardiovasc Imaging."},{"issue":"2","key":"2021082811210396600_CIT0014","doi-asserted-by":"crossref","first-page":"e000582","DOI":"10.1161\/JAHA.113.000582","article-title":"Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations","volume":"3","author":"Fitzgibbons","year":"2014","journal-title":"J Am Heart Assoc."},{"issue":"13","key":"2021082811210396600_CIT0015","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/eurheartj\/eht099","article-title":"Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines","volume":"36","author":"Venteclef","year":"2015","journal-title":"Eur Heart J."},{"issue":"20","key":"2021082811210396600_CIT0016","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.jacc.2018.03.509","article-title":"Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium","volume":"71","author":"Packer","year":"2018","journal-title":"J Am Coll Cardiol."},{"issue":"6","key":"2021082811210396600_CIT0017","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation."},{"issue":"3","key":"2021082811210396600_CIT0018","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"Mari","year":"2001","journal-title":"Diabetes Care."},{"issue":"2","key":"2021082811210396600_CIT0019","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/mrm.1910180211","article-title":"Three-point Dixon technique for true water\/fat decomposition with B0 inhomogeneity correction","volume":"18","author":"Glover","year":"1991","journal-title":"Magn Reson Med."},{"key":"2021082811210396600_CIT0020","author":"Wolf","year":"2021"},{"issue":"1","key":"2021082811210396600_CIT0021","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12968-017-0327-9","article-title":"Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort","volume":"19","author":"Petersen","year":"2017","journal-title":"J Cardiovasc Magn Reson."},{"issue":"1","key":"2021082811210396600_CIT0022","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12020-018-1819-6","article-title":"Factors predicting long-term comorbidities in patients with Cushing\u2019s syndrome in remission","volume":"64","author":"Schernthaner-Reiter","year":"2019","journal-title":"Endocrine."},{"issue":"4","key":"2021082811210396600_CIT0023","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/EC-17-0031","article-title":"Heart, lipids and hormones","volume":"6","author":"Wolf","year":"2017","journal-title":"Endocr Connect."},{"issue":"3","key":"2021082811210396600_CIT0024","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol Rev."},{"issue":"3","key":"2021082811210396600_CIT0025","doi-asserted-by":"crossref","first-page":"e0151301","DOI":"10.1371\/journal.pone.0151301","article-title":"Pericardial- rather than intramyocardial fat is independently associated with left ventricular systolic heart function in metabolically healthy humans","volume":"11","author":"Wolf","year":"2016","journal-title":"PLoS One."},{"issue":"19","key":"2021082811210396600_CIT0026","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1161\/CIRCULATIONAHA.111.039586","article-title":"Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction","volume":"126","author":"Greulich","year":"2012","journal-title":"Circulation."},{"issue":"18","key":"2021082811210396600_CIT0027","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.jacc.2018.07.096","article-title":"Cushing syndrome is associated with subclinical LV dysfunction and increased epicardial adipose tissue","volume":"72","author":"Maurice","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"2021082811210396600_CIT0028","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12933-015-0289-x","article-title":"Impact of long-term steroid therapy on epicardial and pericardial fat deposition: a cardiac MRI study","volume":"14","author":"Kitterer","year":"2015","journal-title":"Cardiovasc Diabetol."},{"issue":"4","key":"2021082811210396600_CIT0029","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S2213-8587(20)30021-8","article-title":"Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial","volume":"8","author":"Pernicova","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"11","key":"2021082811210396600_CIT0030","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/rheumatology\/ker017","article-title":"Prevalence of long-term oral glucocorticoid prescriptions in the UK over the past 20 years","volume":"50","author":"Fardet","year":"2011","journal-title":"Rheumatology (Oxford)."},{"issue":"14","key":"2021082811210396600_CIT0031","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1177\/2047487317717820","article-title":"Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate","volume":"24","author":"Christensen","year":"2017","journal-title":"Eur J Prev Cardiol."},{"issue":"4","key":"2021082811210396600_CIT0032","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/er.2013-1048","article-title":"The treatment of Cushing\u2019s disease","volume":"36","author":"Pivonello","year":"2015","journal-title":"Endocr Rev."},{"issue":"11","key":"2021082811210396600_CIT0033","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2014-2242","article-title":"No evidence of ectopic lipid accumulation in the pathophysiology of the acromegalic cardiomyopathy","volume":"99","author":"Winhofer","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2021082811210396600_CIT0034","doi-asserted-by":"crossref","first-page":"E2341","DOI":"10.1210\/jc.2014-2112","article-title":"Levothyroxine replacement in hypothyroid humans reduces myocardial lipid load and improves cardiac function","volume":"99","author":"Scherer","year":"2014","journal-title":"J Clin Endocrinol Metab."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab556\/40078426\/dgab556.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab556\/40078426\/dgab556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T07:21:24Z","timestamp":1630135284000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article\/doi\/10.1210\/clinem\/dgab556\/6333564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab556","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]},"article-number":"dgab556"}}