{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:13:44Z","timestamp":1790626424546,"version":"4.1.0"},"reference-count":29,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Enthesopathies are the determinant of a poor quality of life in adults with X-linked hypophosphatemia (XLH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe the prevalence of patients with enthesopathies and to identify the risk factors of having enthesopathies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective study in the French Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism between June 2011 and December 2020. Adult XLH patients with full body X-rays performed using the EOS\u00ae low-dose radiation system and clinical data collected from medical records.<\/jats:p>\n                  <jats:p>The main outcome measures were demographics, PHEX mutation, conventional treatment, and dental disease with the presence of enthesopathies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 114 patients included (68% women, mean age 42.2 \u00b1 14.3 years), PHEX mutation was found in 105 patients (94.6%), 86 (77.5%) had been treated during childhood. Enthesopathies (spine and\/or pelvis) were present in 67% of the patients (n = 76). Patients with enthesopathies were significantly older (P = .001) and more frequently reported dental disease collected from medical records (P = .03). There was no correlation between the PHEX mutations and the presence of enthesopathies. Sixty-two patients had a radiographic dental examination in a reference center. Severe dental disease (number of missing teeth, number of teeth endodontically treated, alveolar bone loss, and proportion of patients with 5 abscesses or more) was significantly higher in patients with enthesopathies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adult XLH patients have a high prevalence of enthesopathies in symptomatic adults patients with XLH seen in a reference center. Age and severe dental disease were significantly associated with the presence of enthesopathies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab580","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T16:58:04Z","timestamp":1629305884000},"page":"e224-e235","source":"Crossref","is-referenced-by-count":28,"title":["Prevalence of Enthesopathies in Adults With X-linked Hypophosphatemia: Analysis of Risk Factors"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-9503","authenticated-orcid":false,"given":"Julia","family":"Herrou","sequence":"first","affiliation":[{"name":"INSERM UMR 1153, Universit\u00e9 de Paris, APHP Centre, Paris, France"},{"name":"APHP Centre, Department of Rheumatology, Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle Salcion","family":"Picaud","sequence":"additional","affiliation":[{"name":"APHP Centre, Department of 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