{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:13:29Z","timestamp":1791530009136,"version":"4.3.4"},"reference-count":62,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIHR Clinical Scientist Award","award":["CS-2018-18-ST2-002"],"award-info":[{"award-number":["CS-2018-18-ST2-002"]}]},{"name":"Tommy\u2019s National Centre for Miscarriage Research"},{"name":"NIHR Academic Clinical Lectureship"},{"name":"Imperial College-BRC IPPRF Fellowship"},{"name":"MRC clinical training fellowship","award":["MR\/T006242\/1"],"award-info":[{"award-number":["MR\/T006242\/1"]}]},{"name":"MRC clinical training fellowship","award":["MR\/R000484\/1"],"award-info":[{"award-number":["MR\/R000484\/1"]}]},{"name":"NIHR Biomedical Research Centre"},{"name":"NIHR Professorship","award":["RP-2014-05-001"],"award-info":[{"award-number":["RP-2014-05-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to assess whether kisspeptin levels are altered in women with antenatal complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women with antenatal complications (n\u2005=\u2005105) and those with uncomplicated pregnancies (n\u2005=\u2005265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n\u2005=\u200532], FGR [n\u2005=\u200517], GDM [n\u2005=\u200535], PTB [n\u2005=\u200511], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P\u2005&amp;lt;\u20050.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P\u2005=\u20050.025), for every 1 nmol\/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P\u2005=\u20050.014) and lower in those with GDM (P\u2005=\u20050.020), but not significantly on multivariable analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab617","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T14:41:07Z","timestamp":1629816067000},"page":"e71-e83","source":"Crossref","is-referenced-by-count":24,"title":["Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-5256","authenticated-orcid":false,"given":"Ali","family":"Abbara","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Al-Memar","sequence":"additional","affiliation":[{"name":"Tommy\u2019s National Centre for Miscarriage Research, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College London, Du Cane Road, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-5768","authenticated-orcid":false,"given":"Maria","family":"Phylactou","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Daniels","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei C","family":"Eng","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rans","family":"Nadir","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-0166","authenticated-orcid":false,"given":"Chioma","family":"Izzi-Engbeaya","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A","family":"Clarke","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard G","family":"Mills","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia","family":"Hunjan","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Pacuszka","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Yang","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bech","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Tan","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-2297","authenticated-orcid":false,"given":"Alexander N","family":"Comninos","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, W12, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom W","family":"Kelsey","sequence":"additional","affiliation":[{"name":"School of Computer Science, University of St Andrews, St Andrews, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kyriacou","sequence":"additional","affiliation":[{"name":"Tommy\u2019s National Centre for Miscarriage Research, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College London, Du Cane Road, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanine","family":"Fourie","sequence":"additional","affiliation":[{"name":"Tommy\u2019s National Centre for Miscarriage Research, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College London, Du Cane Road, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-6059","authenticated-orcid":false,"given":"Tom","family":"Bourne","sequence":"additional","affiliation":[{"name":"Tommy\u2019s National Centre for Miscarriage Research, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College London, Du Cane Road, London, UK"},{"name":"KU Leuven, Department of Development and Regeneration, Leuven, 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