{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:21:38Z","timestamp":1784546498490,"version":"3.55.0"},"reference-count":45,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Medical Research Council of Marmara University","award":["SAG-A-120418-0152"],"award-info":[{"award-number":["SAG-A-120418-0152"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Aldosterone synthase deficiency (ASD) caused by mutations in the CYP11B2 gene is characterized by isolated mineralocorticoid deficiency. Data are scarce regarding clinical and biochemical outcomes of the disease in the follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Assessment of the growth and steroid profiles of patients with ASD at the time of diagnosis and after discontinuation of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and method<\/jats:title>\n                  <jats:p>Children with clinical diagnosis of ASD were included in a multicenter study. Growth and treatment characteristics were recorded. Plasma adrenal steroids were measured using liquid chromatography-mass spectrometry. Genetic diagnosis was confirmed by CYP11B2 gene sequencing and in silico analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixteen patients from 12 families were included (8 females; median age at presentation: 3.1 months, range: 0.4 to 8.1). The most common symptom was poor weight gain (56.3%). Median age of onset of fludrocortisone treatment was 3.6 months (range: 0.9 to 8.3). Catch-up growth was achieved at median 2 months (range: 0.5 to 14.5) after treatment. Fludrocortisone could be stopped in 5 patients at a median age of 6.0 years (range: 2.2 to 7.6). Plasma steroid profiles revealed reduced aldosterone synthase activity both at diagnosis and after discontinuation of treatment compared to age-matched controls. We identified 6 novel (p.Y195H, c.1200\u2005+\u20051G\u2005&amp;gt;\u2005A, p.F130L, p.E198del, c.1122-18G\u2005&amp;gt;\u2005A, p.I339_E343del) and 4 previously described CYP11B2 variants. The most common variant (40%) was p.T185I.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fludrocortisone treatment is associated with a rapid catch-up growth and control of electrolyte imbalances in ASD. Decreased mineralocorticoid requirement over time can be explained by the development of physiological adaptation mechanisms rather than improved aldosterone synthase activity. As complete biochemical remission cannot be achieved, a long-term surveillance of these patients is required.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab619","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T17:51:57Z","timestamp":1629481917000},"page":"e106-e117","source":"Crossref","is-referenced-by-count":11,"title":["Catch-up Growth and Discontinuation of Fludrocortisone Treatment in Aldosterone Synthase Deficiency"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-9807","authenticated-orcid":false,"given":"Busra","family":"Gurpinar Tosun","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Kendir Demirkol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Genetics, Umraniye Research and Training Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Seven Menevse","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-8042","authenticated-orcid":false,"given":"Sare Betul","family":"Kaygusuz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Nuri","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selda Ayca","family":"Altincik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Pamukkale University, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamala","family":"Mammadova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Ondokuz Mayis University, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Cayir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Erzurum Education and Research Hospital, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Doger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Gazi University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan","family":"Bayramoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Haseki Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Nalbantoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Dr. Behcet Uz Children\u2019s Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Yesiltepe Mutlu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Ko\u00e7 University Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AghaRza","family":"Aghayev","sequence":"additional","affiliation":[{"name":"Medical Genetics Department, National Hematology and Transfusiology Center, Baku, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-5402","authenticated-orcid":false,"given":"Serap","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-9043","authenticated-orcid":false,"given":"Abdullah","family":"Bereket","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-6866","authenticated-orcid":false,"given":"Tulay","family":"Guran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"issue":"1-2","key":"2021121823145777800_CIT0001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2003.10.013","article-title":"Aldosterone synthase deficiency and related disorders","volume":"217","author":"White","year":"2004","journal-title":"Mol Cell Endocrinol."},{"issue":"1","key":"2021121823145777800_CIT0002","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/jcem-43-1-92","article-title":"Diagnosis and nomenclature of the disorders of the terminal portion of the aldosterone biosynthetic pathway","volume":"43","author":"Ulick","year":"1976","journal-title":"J Clin Endocrinol Metab."},{"issue":"35","key":"2021121823145777800_CIT0003","doi-asserted-by":"crossref","first-page":"20961","DOI":"10.1016\/S0021-9258(19)30030-4","article-title":"Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)","volume":"264","author":"Mornet","year":"1989","journal-title":"J Biol Chem."},{"issue":"4","key":"2021121823145777800_CIT0004","first-page":"421","article-title":"Disorders of steroid 11 beta-hydroxylase isozymes","volume":"15","author":"White","year":"1994","journal-title":"Endocr Rev."},{"issue":"4","key":"2021121823145777800_CIT0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJM199407283310408","article-title":"Disorders of aldosterone biosynthesis and action","volume":"331","author":"White","year":"1994","journal-title":"N Engl J Med."},{"key":"2021121823145777800_CIT0006","doi-asserted-by":"crossref","first-page":"108448","DOI":"10.1016\/j.steroids.2019.108448","article-title":"Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review","volume":"150","author":"Miao","year":"2019","journal-title":"Steroids."},{"issue":"5","key":"2021121823145777800_CIT0007","first-page":"211","article-title":"Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies","volume":"51","author":"Peter","year":"1999","journal-title":"Horm Res."},{"issue":"7240","key":"2021121823145777800_CIT0008","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: prospective cohort study","volume":"320","author":"Ong","year":"2000","journal-title":"BMJ."},{"key":"2021121823145777800_CIT0009","author":"Eureka Lab Division.","year":"2021"},{"issue":"5","key":"2021121823145777800_CIT0010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med."},{"issue":"Web Server issue","key":"2021121823145777800_CIT0011","doi-asserted-by":"crossref","first-page":"W452","DOI":"10.1093\/nar\/gks539","article-title":"SIFT web server: predicting effects of amino acid substitutions on proteins","volume":"40","author":"Sim","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2021121823145777800_CIT0012","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods."},{"issue":"4","key":"2021121823145777800_CIT0013","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmeth.2890","article-title":"MutationTaster2: mutation prediction for the deep-sequencing age","volume":"11","author":"Schwarz","year":"2014","journal-title":"Nat Methods."},{"issue":"11","key":"2021121823145777800_CIT0014","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/bioinformatics\/bty897","article-title":"VarSome: the human genomic variant search engine","volume":"35","author":"Kopanos","year":"2019","journal-title":"Bioinformatics."},{"issue":"10","key":"2021121823145777800_CIT0015","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00431-012-1792-7","article-title":"Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency","volume":"171","author":"Klomchan","year":"2012","journal-title":"Eur J Pediatr."},{"issue":"6","key":"2021121823145777800_CIT0016","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/humu.22981","article-title":"HGVS recommendations for the description of sequence variants: 2016 update","volume":"37","author":"den Dunnen","year":"2016","journal-title":"Hum Mutat."},{"key":"2021121823145777800_CIT0017","article-title":"Data from: catch-up growth and discontinuation of fludrocortisone treatment in aldosterone synthase deficiency\u2014Supplementary Figure 1","author":"Tosun","year":"2021"},{"issue":"11","key":"2021121823145777800_CIT0018","first-page":"3525","article-title":"Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997","volume":"82","author":"Peter","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021121823145777800_CIT0019","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/cen.13603","article-title":"Molecular genetic studies in a case series of isolated hypoaldosteronism due to biosynthesis defects or aldosterone resistance","volume":"88","author":"Turan","year":"2018","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"2","key":"2021121823145777800_CIT0020","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4274\/jcrpe.galenos.2020.2019.0216","article-title":"Clinical and genetic characteristics of patients with corticosterone methyloxidase deficiency type 2: novel mutations in CYP11B2","volume":"13","author":"Turan","year":"2021","journal-title":"J Clin Res Pediatr Endocrinol."},{"issue":"3","key":"2021121823145777800_CIT0021","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4274\/jcrpe.2824","article-title":"Corticosterone methyl oxidase deficiency type 1 with normokalemia in an infant","volume":"8","author":"\u00dcstyol","year":"2016","journal-title":"J Clin Res Pediatr Endocrinol."},{"issue":"5","key":"2021121823145777800_CIT0022","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s004310050833","article-title":"Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II","volume":"157","author":"Peter","year":"1998","journal-title":"Eur J Pediatr."},{"issue":"1-2","key":"2021121823145777800_CIT0023","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jsbmb.2011.01.002","article-title":"Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations","volume":"124","author":"Tin","year":"2011","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"4","key":"2021121823145777800_CIT0024","first-page":"318","article-title":"Aldosterone synthase deficiency type II with hypospadias","volume":"49","author":"Gucev","year":"2012","journal-title":"Indian Pediatr."},{"issue":"S1","key":"2021121823145777800_CIT0025","first-page":"151","article-title":"Neonatal salt loss: not only 21-hydroxilase deficiency: report of six cases with aldosterone deficiency or resistance","volume":"78","author":"Rinaldini","year":"2012","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"2021121823145777800_CIT0026","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/6.11.1829","article-title":"CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency","volume":"6","author":"Joehrer","year":"1997","journal-title":"Hum Mol Genet."},{"issue":"10","key":"2021121823145777800_CIT0027","doi-asserted-by":"crossref","first-page":"E1933","DOI":"10.1073\/pnas.1621082114","article-title":"Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11\u03b2-hydroxylase deficiency","volume":"114","author":"Khattab","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021121823145777800_CIT0028","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbagen.2006.09.013","article-title":"What common structural features and variations of mammalian P450s are known to date?","volume":"1770","author":"Otyepka","year":"2007","journal-title":"Biochim Biophys Acta."},{"issue":"6","key":"2021121823145777800_CIT0029","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF00866491","article-title":"Plasma renin activity as a marker for growth failure due to sodium deficiency in young rats","volume":"6","author":"Ray","year":"1992","journal-title":"Pediatr Nephrol."},{"issue":"2","key":"2021121823145777800_CIT0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/JOE-19-0358","article-title":"Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth","volume":"244","author":"Faught","year":"2020","journal-title":"J Endocrinol."},{"issue":"2","key":"2021121823145777800_CIT0031","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1651-2227.1981.tb05547.x","article-title":"Reinstitution of mineralocorticoid therapy in congenital adrenal hyperplasia. Effects on control and growth","volume":"70","author":"Jansen","year":"1981","journal-title":"Acta Paediatr Scand."},{"issue":"11","key":"2021121823145777800_CIT0032","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1136\/adc.63.11.1399","article-title":"Management of congenital adrenal hyperplasia","volume":"63","author":"Hughes","year":"1988","journal-title":"Arch Dis Child."},{"issue":"4","key":"2021121823145777800_CIT0033","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1530\/acta.0.1020577","article-title":"The effects of long-term normalization of sodium balance on linear growth in disorders with aldosterone deficiency","volume":"102","author":"Kuhnle","year":"1983","journal-title":"Acta Endocrinol (Copenh)."},{"issue":"6","key":"2021121823145777800_CIT0034","first-page":"733","article-title":"Should we monitor more closely the dosage of 9 alpha-fluorohydrocortisone in salt-losing congenital adrenal hyperplasia?","volume":"11","author":"Lopes","year":"1998","journal-title":"J Pediatr Endocrinol Metab."},{"issue":"11","key":"2021121823145777800_CIT0035","doi-asserted-by":"crossref","first-page":"e519","DOI":"10.1111\/j.1651-2227.2012.02823.x","article-title":"Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II","volume":"101","author":"Jessen","year":"2012","journal-title":"Acta Paediatr."},{"issue":"2","key":"2021121823145777800_CIT0036","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1681\/ASN.2013111156","article-title":"Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency","volume":"26","author":"Todkar","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"2021121823145777800_CIT0037","doi-asserted-by":"crossref","first-page":"F323","DOI":"10.1152\/ajprenal.00204.2020","article-title":"Aldosterone-dependent and -independent regulation of Na+ and K+ excretion and ENaC in mouse kidneys","volume":"319","author":"Yang","year":"2020","journal-title":"Am J Physiol Renal Physiol."},{"issue":"3","key":"2021121823145777800_CIT0038","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1203\/PDR.0b013e3181b1bbec","article-title":"Physiological partial aldosterone resistance in human newborns","volume":"66","author":"Martinerie","year":"2009","journal-title":"Pediatr Res."},{"issue":"3","key":"2021121823145777800_CIT0039","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000449057","article-title":"Water balance and \u201csalt wasting\u201d in the first year of life: the role of aldosterone-signaling defects","volume":"86","author":"Bizzarri","year":"2016","journal-title":"Horm Res Paediatr."},{"issue":"5","key":"2021121823145777800_CIT0040","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2265.2007.03116.x","article-title":"Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects","volume":"68","author":"Freel","year":"2008","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"3","key":"2021121823145777800_CIT0041","first-page":"1008","article-title":"Type 1 aldosterone synthase deficiency presenting in a middle-aged man","volume":"86","author":"Kayes-Wandover","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021121823145777800_CIT0042","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/eje.0.1440059","article-title":"Aldosterone synthase deficiency type I with no documented homozygous mutations in the CYP11B2 gene","volume":"144","author":"Wasniewska","year":"2001","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2021121823145777800_CIT0043","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1210\/jc.2003-030353","article-title":"A compound heterozygote case of type II aldosterone synthase deficiency","volume":"88","author":"Dunlop","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021121823145777800_CIT0044","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1210\/clinem\/dgaa765","article-title":"Molecular analysis of the CYP11B2 gene in 62 patients with hypoaldosteronism due to aldosterone synthase deficiency","volume":"106","author":"Merakou","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"issue":"5122","key":"2021121823145777800_CIT0045","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.8342039","article-title":"Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450\u2019s","volume":"261","author":"Ravichandran","year":"1993","journal-title":"Science."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab619\/40366206\/dgab619.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/1\/e106\/41819173\/dgab619.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/1\/e106\/41819173\/dgab619.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T23:16:54Z","timestamp":1639869414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/1\/e106\/6355720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,8,20]]},"published-print":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab619","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,8,20]]}}}