{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:35:05Z","timestamp":1789572905752,"version":"build-2803163510"},"reference-count":30,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Morbid Obesity Centre"},{"DOI":"10.13039\/501100021697","name":"Vestfold Hospital Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100021697","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and \u03b2-cell function in type 2 diabetes remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to compare gastrointestinal hormones and \u03b2-cell function, assessed by an oral glucose tolerance test (OGTT) 5 weeks and 1 year after surgery, hypothesizing higher glucagon-like peptide-1 (GLP-1) levels and greater \u03b2-cell response to glucose after RYGB than after SG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study was a randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcomes were diabetes remission and IVGTT-derived \u03b2-cell function. Participants with obesity and type 2 diabetes were allocated (1:1) to RYGB or SG. We measured gastrointestinal hormone profiles and insulin secretion as \u03b2-cell glucose sensitivity (\u03b2-GS) derived from 180-minute OGTTs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants were 106 patients (67% women), mean (SD) age 48 (10) years. Diabetes remission rates at 1 year were higher after RYGB than after SG (77% vs 48%; P = 0.002). Incremental area under the curve (iAUC0-180) GLP-1 and \u03b2-GS increased more after RYGB than after SG, with 1-year between-group difference 1173 pmol\/L*min (95% CI, 569-1776; P = 0.0010) and 0.45 pmol\/kg\/min\/mmol (95% CI, 0.15-0.75; P = 0.0032), respectively. After surgery, fasting and postprandial ghrelin levels were higher and decremental AUC0-180 ghrelin, iAUC0-180 glucose-dependent insulinotropic polypeptide, and iAUC0-60 glucagon were greater after RYGB than after SG. Diabetes remission at 1 year was associated with higher \u03b2-GS and higher GLP-1 secretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RYGB was associated with greater improvement in \u03b2-cell function and higher postprandial GLP-1 levels than SG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab643","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T15:53:14Z","timestamp":1630425194000},"page":"e756-e766","source":"Crossref","is-referenced-by-count":31,"title":["Gastrointestinal Hormones and \u03b2-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)"],"prefix":"10.1210","volume":"107","author":[{"given":"Farhat","family":"Fatima","sequence":"first","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-0562","authenticated-orcid":false,"given":"J\u00f8ran","family":"Hjelmes\u00e6th","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"},{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re Inge","family":"Birkeland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway"},{"name":"Department of Transplantation, Oslo University Hospital, 0424 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne L\u00f8vdal","family":"Gulseth","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, 0213 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Kristoffer","family":"Hertel","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Svanevik","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"},{"name":"Department of Surgery, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Sandbu","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"},{"name":"Department of Surgery, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada Cvancarova","family":"Sm\u00e5stuen","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"},{"name":"Department of Nutrition and Management, Oslo Metropolitan University, 0130 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2036","authenticated-orcid":false,"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[{"name":"NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University 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