{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:29:56Z","timestamp":1792013396253,"version":"4.4.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Individuals with diabetes mellitus (DM) are susceptible to various infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We estimated the risk of herpes zoster (HZ) among individuals with DM compared with individuals in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, and PerioPath databases from their inception to January 30, 2021, for studies on the risk of HZ in individuals with DM. Two authors independently screened all articles identified. The same 2 authors independently extracted the data. Four case-control studies and 12 cohort studies were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meta-analyses were performed using fixed and mixed-effects models. In the pooled analysis, individuals with DM had a higher risk of developing HZ (pooled relative risk [RR]: 1.38; 95% CI, 1.21-1.57) than individuals in the general population. The results were consistent in subgroup analyses stratified by type of diabetes, age, and study design. In individuals with DM, cardiovascular disease had an additive effect on increasing the risk of HZ (pooled RR: 1.19; 95% CI, 1.11-1.28). There was a linear dose-response association between age and the risk of HZ in individuals with DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with DM have an increased risk of HZ compared with the general population. Varicella vaccination should be provided to individuals with DM regardless of their age, prioritizing older adults and those with cardiovascular disease. Varicella vaccination policies for individuals with DM should be updated based on the evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab675","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T13:11:15Z","timestamp":1631970675000},"page":"586-597","source":"Crossref","is-referenced-by-count":57,"title":["Association Between Diabetes Mellitus and the Risk of Herpes Zoster: A Systematic Review and Meta-analysis"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-3553","authenticated-orcid":false,"given":"Chun-Ta","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei City 10449, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6012-1360","authenticated-orcid":false,"given":"Chi-Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-0287","authenticated-orcid":false,"given":"Heng-You","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Library, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 25160, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chih","family":"Liang","sequence":"additional","affiliation":[{"name":"PO-SIN Clinic, New Taipei City 234007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-7653","authenticated-orcid":false,"given":"Ming-Chieh","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei City 10449, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"issue":"3","key":"2022011806192714600_CIT0001","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMcp1302674","article-title":"Clinical practice: Herpes zoster","volume":"369","author":"Cohen","year":"2013","journal-title":"N Engl J Med."},{"key":"2022011806192714600_CIT0002","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1093\/infdis\/166.Supplement_1.S35","article-title":"Cell-mediated immunity to varicella-zoster virus","volume":"166","author":"Arvin","year":"1992","journal-title":"J Infect Dis."},{"key":"2022011806192714600_CIT0003","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1038\/nrdp.2015.16","article-title":"Varicella zoster virus infection","volume":"1","author":"Gershon","year":"2015","journal-title":"Nat Rev Dis Primers."},{"key":"2022011806192714600_CIT0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1741-7015-8-37","article-title":"The impact of herpes zoster and post-herpetic neuralgia on quality-of-life","volume":"8","author":"Johnson","year":"2010","journal-title":"BMC Med."},{"issue":"10","key":"2022011806192714600_CIT0005","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1086\/320169","article-title":"Herpes zoster in older adults","volume":"32","author":"Schmader","year":"2001","journal-title":"Clin Infect Dis."},{"issue":"1","key":"2022011806192714600_CIT0006","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1473-3099(03)00857-0","article-title":"What does epidemiology tell us about risk factors for herpes zoster?","volume":"4","author":"Thomas","year":"2004","journal-title":"Lancet Infect Dis."},{"issue":"6","key":"2022011806192714600_CIT0007","doi-asserted-by":"crossref","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open."},{"issue":"45","key":"2022011806192714600_CIT0008","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1016\/j.vaccine.2018.08.080","article-title":"Cost of herpes zoster and herpes zoster-related complications among immunocompromised individuals","volume":"36","author":"Meyers","year":"2018","journal-title":"Vaccine."},{"issue":"9","key":"2022011806192714600_CIT0009","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.vaccine.2018.11.079","article-title":"Costs of herpes zoster complications in older adults: a cohort study of US claims database","volume":"37","author":"Meyers","year":"2019","journal-title":"Vaccine."},{"key":"2022011806192714600_CIT0010","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res Clin Pract."},{"issue":"2","key":"2022011806192714600_CIT0011","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000345107","article-title":"Diabetes and infection: is there a link?\u2013A mini-review","volume":"59","author":"Knapp","year":"2013","journal-title":"Gerontology."},{"issue":"12","key":"2022011806192714600_CIT0012","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.mayocp.2017.10.009","article-title":"Risk factors for herpes zoster: a systematic review and meta-analysis","volume":"92","author":"Kawai","year":"2017","journal-title":"Mayo Clin Proc."},{"issue":"1","key":"2022011806192714600_CIT0013","doi-asserted-by":"crossref","first-page":"ofaa005","DOI":"10.1093\/ofid\/ofaa005","article-title":"Risk factors for herpes zoster infection: a meta-analysis","volume":"7","author":"Marra","year":"2020","journal-title":"Open Forum Infect Dis."},{"issue":"3","key":"2022011806192714600_CIT0014","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s15010-007-6347-x","article-title":"Diabetes as a risk factor for herpes zoster infection: results of a population-based study in Israel","volume":"36","author":"Heymann","year":"2008","journal-title":"Infection."},{"issue":"4","key":"2022011806192714600_CIT0015","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s15010-014-0645-x","article-title":"Risk of herpes zoster among diabetics: a matched cohort study in a US insurance claim database before introduction of vaccination, 1997-2006","volume":"42","author":"Guignard","year":"2014","journal-title":"Infection."},{"issue":"5","key":"2022011806192714600_CIT0016","doi-asserted-by":"crossref","first-page":"e0155175","DOI":"10.1371\/journal.pone.0155175","article-title":"Association of herpes zoster and type 1 diabetes mellitus","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One."},{"issue":"11","key":"2022011806192714600_CIT0017","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1080\/21645515.2017.1368600","article-title":"Risk and impact of herpes zoster on patients with diabetes: a population-based study, 2009-2014","volume":"13","author":"Mu\u00f1oz-Quiles","year":"2017","journal-title":".Hum Vaccin Immunother."},{"issue":"5","key":"2022011806192714600_CIT0018","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jcjd.2017.10.060","article-title":"The prevalence and risk for herpes zoster infection in adult patients with diabetes mellitus in the Canadian Primary Care Sentinel Surveillance Network","volume":"42","author":"Queenan","year":"2018","journal-title":"Can J Diabetes."},{"issue":"18","key":"2022011806192714600_CIT0019","doi-asserted-by":"crossref","first-page":"e15463","DOI":"10.1097\/MD.0000000000015463","article-title":"Real-world database investigating the association between diabetes mellitus and herpes zoster in Taiwan","volume":"98","author":"Lai","year":"2019","journal-title":"Medicine (Baltimore)."},{"key":"2022011806192714600_CIT0020","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ."},{"issue":"3","key":"2022011806192714600_CIT0021","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00001648-199305000-00005","article-title":"Meta-analysis of epidemiologic dose-response data","volume":"4","author":"Berlin","year":"1993","journal-title":"Epidemiology."},{"issue":"11","key":"2022011806192714600_CIT0022","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/oxfordjournals.aje.a116237","article-title":"Methods for trend estimation from summarized dose-response data, with applications to meta-analysis","volume":"135","author":"Greenland","year":"1992","journal-title":"Am J Epidemiol."},{"issue":"2","key":"2022011806192714600_CIT0023","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jcv.2012.06.020","article-title":"Herpes zoster: family history and psychological stress-case-control study","volume":"55","author":"Lasserre","year":"2012","journal-title":"J Clin Virol."},{"key":"2022011806192714600_CIT0024","doi-asserted-by":"crossref","first-page":"g2911","DOI":"10.1136\/bmj.g2911","article-title":"Quantification of risk factors for herpes zoster: population based case-control study","volume":"348","author":"Forbes","year":"2014","journal-title":"BMJ."},{"issue":"1","key":"2022011806192714600_CIT0025","doi-asserted-by":"crossref","first-page":"e0146750","DOI":"10.1371\/journal.pone.0146750","article-title":"Increased risk of Herpes Zoster in diabetic patients comorbid with coronary artery disease and microvascular disorders: a population-based study in Taiwan","volume":"11","author":"Ke","year":"2016","journal-title":"PLoS One."},{"issue":"6","key":"2022011806192714600_CIT0026","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2340\/00015555-0729","article-title":"Epidemiological features and costs of herpes zoster in Taiwan: a national study 2000 to 2006","volume":"89","author":"Jih","year":"2009","journal-title":"Acta Derm Venereol."},{"issue":"6","key":"2022011806192714600_CIT0027","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s15010-011-0162-0","article-title":"Risk of Herpes zoster in patients with underlying diseases: a retrospective hospital-based cohort study","volume":"39","author":"Hata","year":"2011","journal-title":"Infection."},{"issue":"4","key":"2022011806192714600_CIT0028","doi-asserted-by":"crossref","first-page":"e1001420","DOI":"10.1371\/journal.pmed.1001420","article-title":"Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study","volume":"10","author":"Langan","year":"2013","journal-title":"PLoS Med."},{"issue":"5","key":"2022011806192714600_CIT0029","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jinf.2013.06.016","article-title":"A population based study of the epidemiology of Herpes Zoster and its complications","volume":"67","author":"Weitzman","year":"2013","journal-title":"J Infect."},{"issue":"6","key":"2022011806192714600_CIT0030","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.4161\/hv.28620","article-title":"Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster: a population-based study from primary care in Madrid (Spain)","volume":"10","author":"Esteban-Vasallo","year":"2014","journal-title":"Hum Vaccin Immunother."},{"issue":"2","key":"2022011806192714600_CIT0031","doi-asserted-by":"crossref","first-page":"ofu049","DOI":"10.1093\/ofid\/ofu049","article-title":"Incidence of herpes zoster and persistent post-zoster pain in adults with or without diabetes in the United States","volume":"1","author":"Suaya","year":"2014","journal-title":"Open Forum Infect Dis."},{"issue":"13","key":"2022011806192714600_CIT0032","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1017\/S0950268814003653","article-title":"Risk factors for herpes zoster in a large cohort of unvaccinated older adults: a prospective cohort study","volume":"143","author":"Liu","year":"2015","journal-title":"Epidemiol Infect."},{"issue":"2","key":"2022011806192714600_CIT0033","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jinf.2020.12.013","article-title":"Incidence and disease burden of herpes zoster in the population aged \u226550 years in China: data from an integrated health care network","volume":"82","author":"Sun","year":"2021","journal-title":"J Infect."},{"key":"2022011806192714600_CIT0034","author":"Huang","year":"2021"},{"issue":"1","key":"2022011806192714600_CIT0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/dmrr.682","article-title":"Common infections in diabetes: pathogenesis, management and relationship to glycaemic control","volume":"23","author":"Peleg","year":"2007","journal-title":"Diabetes Metab Res Rev."},{"issue":"10","key":"2022011806192714600_CIT0036","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1086\/644646","article-title":"Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals","volume":"200","author":"Okamoto","year":"2009","journal-title":"J Infect Dis."},{"issue":"16","key":"2022011806192714600_CIT0037","doi-asserted-by":"crossref","first-page":"e25292","DOI":"10.1097\/MD.0000000000025292","article-title":"The incidence of herpes zoster in patients with diabetes mellitus: a meta-analysis of cohort studies","volume":"100","author":"Lai","year":"2021","journal-title":"Medicine (Baltimore)."},{"issue":"3","key":"2022011806192714600_CIT0038","doi-asserted-by":"crossref","first-page":"103","DOI":"10.15585\/mmwr.mm6703a5","article-title":"Recommendations of the Advisory Committee on Immunization Practices for use of herpes zoster vaccines","volume":"67","author":"Dooling","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"2022011806192714600_CIT0039","volume-title":"Updated Recommendations on the Use of Herpes Zoster Vaccines","author":"National Advisory Committee on Immunization","year":"2018"},{"key":"2022011806192714600_CIT0040","article-title":"Bundesministerium f\u00fcr Arbeit, Soziales, Gesundheit und Konsumentenschutz (Hg.)(2018): Angeh\u00f6rigenpflege in \u00d6sterreich","author":"Nagl-Cupal"},{"issue":"1","key":"2022011806192714600_CIT0041","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-8587(17)30186-9","article-title":"Type 2 diabetes in adolescents and young adults","volume":"6","author":"Lascar","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"1","key":"2022011806192714600_CIT0042","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc Diabetol."},{"issue":"10","key":"2022011806192714600_CIT0043","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.mayocp.2012.05.021","article-title":"Chronic medical conditions as risk factors for herpes zoster","volume":"87","author":"Joesoef","year":"2012","journal-title":"Mayo Clin Proc."},{"issue":"6","key":"2022011806192714600_CIT0044","doi-asserted-by":"crossref","first-page":"421","DOI":"10.7326\/0003-4819-141-6-200409210-00007","article-title":"Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus","volume":"141","author":"Selvin","year":"2004","journal-title":"Ann Intern Med."},{"issue":"7","key":"2022011806192714600_CIT0045","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2337\/diacare.19.7.689","article-title":"Cardiovascular disease and its risk factors in IDDM in Europe. EURODIAB IDDM Complications Study Group","volume":"19","author":"Koivisto","year":"1996","journal-title":"Diabetes Care."},{"issue":"5","key":"2022011806192714600_CIT0046","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1001\/archinternmed.2011.2","article-title":"Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors","volume":"171","author":"Wannamethee","year":"2011","journal-title":"Arch Intern Med."},{"issue":"1","key":"2022011806192714600_CIT0047","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12933-021-01362-y","article-title":"Cardiorenal outcomes with sodium\/glucose cotransporter-2 inhibitors in patients with type 2 diabetes and low kidney risk: real world evidence","volume":"20","author":"Schechter","year":"2021","journal-title":"Cardiovasc Diabetol."},{"issue":"25","key":"2022011806192714600_CIT0048","first-page":"265","article-title":"Varicella and herpes zoster vaccines: WHO position paper, June 2014.","volume":"89","year":"2014","journal-title":"Wkly Epidemiol Rec."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab675\/40461316\/dgab675.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/2\/586\/42224529\/dgab675.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/2\/586\/42224529\/dgab675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T01:19:50Z","timestamp":1642468790000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/2\/586\/6372265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,18]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,9,18]]},"published-print":{"date-parts":[[2022,1,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab675","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,9,18]]}}}