{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:47Z","timestamp":1792801967576,"version":"4.5.0"},"reference-count":50,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020","award":["667375"],"award-info":[{"award-number":["667375"]}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001828","name":"Erasmus University Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Organization for Scientific Research","award":["948-00-010"],"award-info":[{"award-number":["948-00-010"]}],"id":[{"id":"https:\/\/ror.org\/04jsz6e67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Netherlands Organization for Scientific Research","award":["918-46-615"],"award-info":[{"award-number":["918-46-615"]}],"id":[{"id":"https:\/\/ror.org\/04jsz6e67","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Institute for Diseases in the Elderly"},{"DOI":"10.13039\/501100005992","name":"Ministry of Education, Culture and Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Welfare and Sports","id":[{"id":"https:\/\/ror.org\/041evnj42","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Municipality of Rotterdam"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Whether thyroid dysfunction is related to altered brain circulation in the general population remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We determined the association of thyroid hormones with different markers of brain circulation within community-dwelling elderly people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a population-based study of 3 subcohorts of the Rotterdam Study, starting in 1989, 2000, and 2006. A total of 5142 participants (mean age, 63.8 years; 55.4% women), underwent venipuncture to measure serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Between 2005 and 2015, all participants underwent phase-contrast brain magnetic resonance imaging to assess global brain perfusion (mL of blood flow\/100 mL of brain\/minute). Arteriolar retinal calibers were assessed using digitized images of stereoscopic fundus color transparencies in 3105 participants as markers of microcirculation. We investigated associations of TSH, FT4 with brain circulation measures using (non)linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FT4 (in pmol\/L) levels had an inverse U-shaped association with global brain perfusion, such that high and low levels of FT4 were associated with lower global brain perfusion than middle levels of FT4. The difference in global brain perfusion between high FT4 levels (25 pmol\/L) and middle FT4 levels (FT4 = 15 pmol\/L; P nonlinearity = .002) was up to \u20132.44 mL (95% CI \u20134.31; \u20130.56). Higher and lower levels of FT4, compared with middle FT4 levels, were associated with arteriolar retinal vessels (mean difference up to \u20132.46 \u00b5m, 95% CI \u20134.98; 0.05 for lower FT4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that thyroid dysfunction could lead to brain diseases such as stroke or dementia through suboptimal brain circulation that is potentially modifiable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab744","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T14:32:51Z","timestamp":1633962771000},"page":"e1293-e1302","source":"Crossref","is-referenced-by-count":20,"title":["Thyroid Status and Brain Circulation: The Rotterdam Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-5631","authenticated-orcid":false,"given":"Lana","family":"Fani","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Roa Due\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike W","family":"Vernooij","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline C W","family":"Klaver","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Kamran","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Neurology, Erasmus MC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Internal Medicine, Erasmus MC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-5418","authenticated-orcid":false,"given":"Layal","family":"Chaker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Internal Medicine, Erasmus MC, The 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