{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:24:48Z","timestamp":1791429888736,"version":"4.3.3"},"reference-count":40,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Research Priority Program of the University of Zurich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Most patients with adrenal incidentaloma have nonfunctional lesions that do not require treatment, while others have functional or malignant tumors that require intervention. The plasma steroid metabolome may be useful to assess therapeutic need.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to establish the utility of plasma steroid profiling combined with metanephrines and adrenal tumor size for the differential diagnosis of patients with adrenal incidentaloma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cross-sectional study, which took place at 7 European tertiary-care centers, comprised 577 patients with adrenal incidentaloma, including 19, 77, 65, 104 and 312 respective patients with adrenocortical carcinoma (ACC), pheochromocytoma (PHEO), primary aldosteronism (PA), autonomous cortisol secretion (ACS), and nonfunctional adrenal incidentaloma (NFAI). Mesaures of diagnostic performance were assessed (with [95% CIs]) for discriminating different subgroups of patients with adrenal incidentaloma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with ACC were characterized by elevated plasma concentrations of 11-deoxycortisol, 11-deoxycorticosterone, 17-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone-sulfate, whereas patients with PA had elevations of aldosterone, 18-oxocortisol, and 18-hydroxycortisol. A selection of those 8 steroids, combined with 3 others (cortisol, corticosterone, and dehydroepiandrosterone) and plasma metanephrines, proved optimal for identifying patients with ACC, PA, and PHEO at respective sensitivities of 83.3% (66.1%-100%), 90.8% (83.7%-97.8%), and 94.8% (89.8%-99.8%); and specificities of 98.0% (96.9%-99.2%), 92.0% (89.6%-94.3%), and 98.6% (97.6%-99.6%). With the addition of tumor size, discrimination improved further, particularly for ACC (100% [100%-100%] sensitivity, 99.5% [98.9%-100%] specificity). In contrast, discrimination of ACS and NFAI remained suboptimal (70%-71% sensitivity, 89%-90% specificity).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among patients with adrenal incidentaloma, the combination of plasma steroid metabolomics with routinely available plasma free metanephrines and data from imaging studies may facilitate the identification of almost all clinically relevant adrenal tumors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab751","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:43:34Z","timestamp":1634773414000},"page":"e1181-e1192","source":"Crossref","is-referenced-by-count":48,"title":["Plasma Steroid Profiling in Patients With Adrenal Incidentaloma"],"prefix":"10.1210","volume":"107","author":[{"given":"Kristina","family":"Berke","sequence":"first","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-2557","authenticated-orcid":false,"given":"Georgiana","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Masjkur","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-7861","authenticated-orcid":false,"given":"Otilia","family":"Kimpel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, 97082 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dischinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, 97082 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-675X","authenticated-orcid":false,"given":"Mirko","family":"Peitzsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kwapiszewska","sequence":"additional","affiliation":[{"name":"Department of Hypertension, National Institute of Cardiology, 04-828 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Dobrowolski","sequence":"additional","affiliation":[{"name":"Department of Hypertension, National Institute of Cardiology, 04-828 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"N\u00f6lting","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8057 Zurich, Switzerland"},{"name":"Department of Medicine IV, University Hospital, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University Hospital, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-3984","authenticated-orcid":false,"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8057 Zurich, Switzerland"},{"name":"Department of Medicine IV, University Hospital, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-0244","authenticated-orcid":false,"given":"Aleksander","family":"Prejbisz","sequence":"additional","affiliation":[{"name":"Department of Hypertension, National Institute of Cardiology, 04-828 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques W M","family":"Lenders","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1677-388X","authenticated-orcid":false,"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, 97082 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-9903","authenticated-orcid":false,"given":"Graeme","family":"Eisenhofer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"issue":"2","key":"2022021713145763200_CIT0001","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/er.2002-0031","article-title":"The clinically inapparent adrenal mass: update in diagnosis and management","volume":"25","author":"Mansmann","year":"2004","journal-title":"Endocr Rev."},{"issue":"6","key":"2022021713145763200_CIT0002","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/endrev\/bnaa008","article-title":"Adrenal incidentaloma","volume":"41","author":"Sherlock","year":"2020","journal-title":"Endocr Rev."},{"issue":"16","key":"2022021713145763200_CIT0003","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1056\/NEJMcp2031112","article-title":"Adrenal incidentaloma","volume":"384","author":"Kebebew","year":"2021","journal-title":"N Engl J Med."},{"issue":"2","key":"2022021713145763200_CIT0004","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1530\/EJE-16-0461","article-title":"Management of endocrine disease: imaging for the diagnosis of malignancy in incidentally discovered adrenal masses: a systematic review and meta-analysis","volume":"175","author":"Dinnes","year":"2016","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2022021713145763200_CIT0005","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology clinical practice guideline in collaboration with the European Network for the Study of Adrenal Tumors","volume":"175","author":"Fassnacht","year":"2016","journal-title":"Eur J Endocrinol."},{"issue":"5","key":"2022021713145763200_CIT0006","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/EJE-17-1056","article-title":"Diagnostic accuracy of computed tomography to identify adenomas among adrenal incidentalomas in an endocrinological population","volume":"178","author":"Marty","year":"2018","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2022021713145763200_CIT0007","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1210\/jc.2018-01532","article-title":"CT characteristics of pheochromocytoma: relevance for the evaluation of adrenal incidentaloma","volume":"104","author":"Canu","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"2022021713145763200_CIT0008","doi-asserted-by":"crossref","first-page":"e2016209","DOI":"10.1001\/jamanetworkopen.2020.16209","article-title":"Use of steroid profiling combined with machine learning for identification and subtype classification in primary aldosteronism","volume":"3","author":"Eisenhofer","year":"2020","journal-title":"JAMA Netw Open."},{"issue":"3","key":"2022021713145763200_CIT0009","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/MED.0000000000000475","article-title":"Serum steroid profiling by mass spectrometry in adrenocortical tumors: diagnostic implications","volume":"26","author":"Fanelli","year":"2019","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"12","key":"2022021713145763200_CIT0010","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1210\/jc.2011-1565","article-title":"Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors","volume":"96","author":"Arlt","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"2022021713145763200_CIT0011","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S2213-8587(20)30218-7","article-title":"Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study","volume":"8","author":"Bancos","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"2022021713145763200_CIT0012","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1530\/EJE-18-0782","article-title":"Plasma steroid metabolome profiling for the diagnosis of adrenocortical carcinoma","volume":"180","author":"Schweitzer","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"12","key":"2022021713145763200_CIT0013","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1373\/clinchem.2017.277624","article-title":"A 13-steroid serum panel based on LC-MS\/MS: use in detection of adrenocortical carcinoma","volume":"63","author":"Taylor","year":"2017","journal-title":"Clin Chem."},{"issue":"3","key":"2022021713145763200_CIT0014","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1373\/clinchem.2015.251199","article-title":"Mass spectrometry-based adrenal and peripheral venous steroid profiling for subtyping primary aldosteronism","volume":"62","author":"Eisenhofer","year":"2016","journal-title":"Clin Chem."},{"key":"2022021713145763200_CIT0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.coemr.2019.07.002","article-title":"Steroid metabolomics: Machine learning and multidimensional diagnostics for adrenal cortical tumors, hyperplasias, and related disorders","volume":"8","author":"Eisenhofer","year":"2019","journal-title":"Curr Opin Endocr Metab Res."},{"issue":"1","key":"2022021713145763200_CIT0016","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/HYPERTENSIONAHA.119.13866","article-title":"Comprehensive analysis of steroid biomarkers for guiding primary aldosteronism subtyping","volume":"75","author":"Turcu","year":"2020","journal-title":"Hypertension."},{"issue":"9","key":"2022021713145763200_CIT0017","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1210\/JC.2015-1992","article-title":"Steroid profiling by LC-MS\/MS in nonsecreting and subclinical cortisol-secreting adrenocortical adenomas","volume":"100","author":"Di Dalmazi","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2022021713145763200_CIT0018","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1373\/clinchem.2017.282582","article-title":"Plasma steroid metabolome profiling for diagnosis and subtyping patients with Cushing syndrome","volume":"64","author":"Eisenhofer","year":"2018","journal-title":"Clin Chem."},{"issue":"10","key":"2022021713145763200_CIT0019","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1210\/jc.2018-02349","article-title":"Plasma steroid profiles in subclinical compared with overt adrenal Cushing syndrome","volume":"104","author":"Masjkur","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2022021713145763200_CIT0020","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1210\/jc.2019-00365","article-title":"The steroid profile of adrenal incidentalomas: subtyping subjects with high cardiovascular risk","volume":"104","author":"Di Dalmazi","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"key":"2022021713145763200_CIT0021","doi-asserted-by":"crossref","article-title":"Plasma steroid profiling in patients with adrenal incidentaloma.\u201d","author":"Berke","DOI":"10.1210\/clinem\/dgab751"},{"issue":"4","key":"2022021713145763200_CIT0022","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur J Endocrinol."},{"issue":"5","key":"2022021713145763200_CIT0023","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"key":"2022021713145763200_CIT0024","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jsbmb.2014.10.006","article-title":"An LC-MS\/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism","volume":"145","author":"Peitzsch","year":"2015","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"8","key":"2022021713145763200_CIT0025","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/clinchem\/hvab060","article-title":"Harmonization of LC-MS\/MS measurements of plasma free normetanephrine, metanephrine, and 3-methoxytyramine","volume":"67","author":"Peitzsch","year":"2021","journal-title":"Clin Chem."},{"key":"2022021713145763200_CIT0026","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2017.05.002","article-title":"Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS\/MS: impact of gender, age, oral contraceptives, body mass index and blood pressure status","volume":"470","author":"Eisenhofer","year":"2017","journal-title":"Clin Chim Acta."},{"key":"2022021713145763200_CIT0027","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2018.12.019","article-title":"Reference intervals for LC-MS\/MS measurements of plasma free, urinary free and urinary acid-hydrolyzed deconjugated normetanephrine, metanephrine and methoxytyramine","volume":"490","author":"Eisenhofer","year":"2019","journal-title":"Clin Chim Acta."},{"key":"2022021713145763200_CIT0028","doi-asserted-by":"crossref","first-page":"194s","DOI":"10.1016\/S0753-3322(00)80043-8","article-title":"Urinary steroid profile in adrenocortical tumors","volume":"54","author":"Kikuchi","year":"2000","journal-title":"Biomed Pharmacother."},{"issue":"6","key":"2022021713145763200_CIT0029","first-page":"463","article-title":"Use of urinary steroid profiling for diagnosing and monitoring adrenocortical tumours","volume":"15","author":"Tiu","year":"2009","journal-title":"Hong Kong Med J."},{"issue":"4","key":"2022021713145763200_CIT0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12672-015-0224-3","article-title":"Diagnostic value of urinary steroid profiling in the evaluation of adrenal tumors","volume":"6","author":"Kerkhofs","year":"2015","journal-title":"Horm Cancer."},{"issue":"5-6","key":"2022021713145763200_CIT0031","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12672-016-0267-0","article-title":"Different types of urinary steroid profiling obtained by high-performance liquid chromatography and gas chromatography-mass spectrometry in patients with adrenocortical carcinoma","volume":"7","author":"Velikanova","year":"2016","journal-title":"Horm Cancer."},{"issue":"12","key":"2022021713145763200_CIT0032","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1373\/clinchem.2017.271106","article-title":"High-resolution, accurate-mass (HRAM) mass spectrometry urine steroid profiling in the diagnosis of adrenal disorders","volume":"63","author":"Hines","year":"2017","journal-title":"Clin Chem."},{"key":"2022021713145763200_CIT0033","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.steroids.2018.04.006","article-title":"Urinary steroid profiling by gas chromatography mass spectrometry: early features of malignancy in patients with adrenal incidentalomas","volume":"135","author":"Shafigullina","year":"2018","journal-title":"Steroids."},{"issue":"3","key":"2022021713145763200_CIT0034","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jc.2011-2384","article-title":"18-Hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes","volume":"97","author":"Mulatero","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2022021713145763200_CIT0035","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1161\/HYPERTENSIONAHA.114.04453","article-title":"Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism","volume":"65","author":"Satoh","year":"2015","journal-title":"Hypertension."},{"issue":"7","key":"2022021713145763200_CIT0036","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/clinchem\/hvab056","article-title":"Method-specific cortisol and dexamethasone thresholds increase clinical specificity of the dexamethasone suppression test for Cushing syndrome","volume":"67","author":"Vogg","year":"2021","journal-title":"Clin Chem."},{"issue":"3","key":"2022021713145763200_CIT0037","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/imj.14332","article-title":"Three-year follow up of adrenal incidentalomas in a New Zealand centre","volume":"50","author":"Goh","year":"2020","journal-title":"Intern Med J."},{"issue":"11","key":"2022021713145763200_CIT0038","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1373\/clinchem.2018.291369","article-title":"Biochemical diagnosis of chromaffin cell tumors in patients at high and low risk of disease: plasma versus urinary free or deconjugated O-methylated catecholamine metabolites","volume":"64","author":"Eisenhofer","year":"2018","journal-title":"Clin Chem."},{"key":"2022021713145763200_CIT0039","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cca.2020.04.019","article-title":"Mass spectrometry reveals misdiagnosis of primary aldosteronism with scheduling for adrenalectomy due to immunoassay interference","volume":"507","author":"Constantinescu","year":"2020","journal-title":"Clin Chim Acta."},{"issue":"12","key":"2022021713145763200_CIT0040","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1373\/clinchem.2017.281048","article-title":"Steroid profiling for adrenocortical disorders: a pathway for omics-based diagnostics","volume":"63","author":"Eisenhofer","year":"2017","journal-title":"Clin Chem."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab751\/41929749\/dgab751.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/e1181\/42544530\/dgab751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/e1181\/42544530\/dgab751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T13:16:12Z","timestamp":1645103772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/3\/e1181\/6403350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,10,19]]},"published-print":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab751","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2021,10,19]]}}}